Autologous Platelet Gel and its Clinical application
Autologous Platelet Gel and its Clinical application
Keywords:
Autologous, Platelet Gel, Clinical ApplicationAbstract
Platelets are attracted to a wound or injury site stimulating the clotting and healing cascades. Degranulated platelets release numerous substances including proteins known as growth factors. Growth factors signal undifferentiated stem cells to the site, promote cell mitosis, and stimulate osteogenesis and angiogenesis. Cytokines, which attract neutrophils, are also released from platelet granules. Concentrating platelets 4x to 5x the baseline level accelerates the healing process. When platelet rich plasma is mixed with an activator, a platelet gel will form. Clinical applications of platelet gel are numerous. Some benefits include a marked decrease in post-surgical swelling and bruising, reduction in surgical site pain, elimination of drains, and acceleration of bone growth and soft tissue healing. Scientific publications support that autologous biomaterial accelerates the healing process.
References
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2. Antitua E, Andia I, Sanchez M, Azofra J, et al. Autologous preparations rich in growth factors promote proliferation and induce VEGF and HGF productions by human tendon cells in culture. J Orthop Res.; 23:281–6, 2005.
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8. Kajikawa Y, Morihara T, Sakamoto H, et al. PRP enhances the initial mobilization of circulation-derived cells for tendon healing. Journal of Cell Physiology; 2153:837–45, 2008.
9. Kirker-Head CA. Potential applications and delivery strategies for bone morphogenetic proteins. Adverse Drug Delivery Review, 43:65–92, 2000.
10. Molloy T, Wang Y, Murrell G. The roles of growth factors in tendon and ligament healing. Sports Medicine, 335:381–94, 2003.
11. Raghoebar GM, Schortinghuis J, Liem R, Ruben J, Van der Wal J. Does platelet-rich plasma promote remodeling of autologous bone grafts used for the augmentation of the maxillary sinus floor? Clin Oral Implants Res.16:349–56, 2005.
12. Taylor M, Norman T, Clovis N, Blaha D. The response of rabbit patellar tendons after autologous blood injection. Med Sci Sports Exerc.34 1:70–3, 2002.
13. Werner S, Grose R. Regulation of wound healing by growth factors and cytokines. Physiology Review, 83:835–70, 2003.
14. Whitman DH, Berry RL, Green DM. Platelet Gel: An autologous alternative to fibrin glue with applications in oral and maxillofacial surgery. J Oral Maxillofac Surg. 55:1294-1299, 1997.
15. Green DM, Whitman DH, Goldman CD. Platelet gel as an intraoperatively procured platelet-based alternative to fibrin-glue: Program implementation and uses in noncardiovascular procedures, 1997.
16. Mancuso JD, Bennion JW, Hull MJ, et al. Platelet-rich plasma: A preliminary report in routine impacted mandibular third molar surgery and the prevention of alveolar osteitis. J Oral Maxillofac Surg. 61, 2003.
17. Stover EP, Siegel LC, Shuer LM et al. Intraoperatively prepared platelet gel as an alternative to fibrin glue in dural wound repair. Transfusion AABB. 36, 1996.
18. Rieman P. Platelet-rich plasma reduces bleeding, speeds healing. Cosmetic Surgery Times. 38, 2000.
19. Man D, Plosker H, Winland-Brown JE. The use of platelet gel and fibrin glue in cosmetic surgery. Plastic Reconstr Surg.107:229-237, 2001.
20. Clevens RA. Autologous Platelet rich plasma in facial plastic surgery. Proceedings from the 8th International Symposium of Facial Plastic Surgery, 2002.
21. Kerner MM. The use of autologous platelet-gel as an intranasal dressing in functional endoscopic sinus surgery. Presented at the American Rhinologic Society, 2001.
22. Mooar PA, Gardner MJ, Klepchick PR, et al. The efficacy of autologous platelet gel in total knee arthroplasty. Presented at AAOS, 2000.
23. Coetzee JC, Pomerey G, Watts JD. The use of autologous concentrated growth factors in fusion rates in total ankle replacement.American Academy of Orthopeadic Surgeons, 2005.
24. Banco RJ, Kwon B, Jenis LG. Prospective randomized study of autologous growth factors in lumbar fusion clinical/radiographic. American Academy of Orthopeadic Surgeons, 2005.
25. Barrett SL. A new approach to using growth factors in wound healing, 2005.
26. Aminian B, Shams M, Karim-Aghaee B, et al. The role of the autologous platelet derived growth factor in the management of decubitus ulcer, 2003.
27. Barrett SL, Erredge SE. Growth factors for chronic plantar fasciitis? Podiatry Today, 37-42, 2004.
2. Antitua E, Andia I, Sanchez M, Azofra J, et al. Autologous preparations rich in growth factors promote proliferation and induce VEGF and HGF productions by human tendon cells in culture. J Orthop Res.; 23:281–6, 2005.
3. Brecher ME, Butch SH, Calhoun AR et al. ed. Technical manual of the American Association of Blood Banks 15th edn, 283-336, 2005.
4. Eppley B, Woodell J, Higgins J Platelet Quantification and growth factor analysis from platelet-rich plasma: Implications for wound healing. Plast Reconstr Surg. 1146:1502–7, 2004.
5. Everts P, Devilee R, Mahoney C. Platelet gel and fibrin sealant reduce allogeneic blood transfusions in total knee arthroplasty. Acta Anaesthesiol Scand.; 50:593–9, 2006.
6. Everts P, Knape J, Weirich G, Schonberger J, Hoffman J, Overdevest E, et al. Platelet rich plasma and platelet gel: a review. JECT. 38:174–87, 2006.
7. Froum SJ, Wallace S, Tarnow DP, Cho SC. Effect of platelet-rich plasma on bone growth and osseointegration in human maxillary sinus grafts: three bilateral case reports. Int J Periodontics Restorative Dentistry, 22:45–53, 2002.
8. Kajikawa Y, Morihara T, Sakamoto H, et al. PRP enhances the initial mobilization of circulation-derived cells for tendon healing. Journal of Cell Physiology; 2153:837–45, 2008.
9. Kirker-Head CA. Potential applications and delivery strategies for bone morphogenetic proteins. Adverse Drug Delivery Review, 43:65–92, 2000.
10. Molloy T, Wang Y, Murrell G. The roles of growth factors in tendon and ligament healing. Sports Medicine, 335:381–94, 2003.
11. Raghoebar GM, Schortinghuis J, Liem R, Ruben J, Van der Wal J. Does platelet-rich plasma promote remodeling of autologous bone grafts used for the augmentation of the maxillary sinus floor? Clin Oral Implants Res.16:349–56, 2005.
12. Taylor M, Norman T, Clovis N, Blaha D. The response of rabbit patellar tendons after autologous blood injection. Med Sci Sports Exerc.34 1:70–3, 2002.
13. Werner S, Grose R. Regulation of wound healing by growth factors and cytokines. Physiology Review, 83:835–70, 2003.
14. Whitman DH, Berry RL, Green DM. Platelet Gel: An autologous alternative to fibrin glue with applications in oral and maxillofacial surgery. J Oral Maxillofac Surg. 55:1294-1299, 1997.
15. Green DM, Whitman DH, Goldman CD. Platelet gel as an intraoperatively procured platelet-based alternative to fibrin-glue: Program implementation and uses in noncardiovascular procedures, 1997.
16. Mancuso JD, Bennion JW, Hull MJ, et al. Platelet-rich plasma: A preliminary report in routine impacted mandibular third molar surgery and the prevention of alveolar osteitis. J Oral Maxillofac Surg. 61, 2003.
17. Stover EP, Siegel LC, Shuer LM et al. Intraoperatively prepared platelet gel as an alternative to fibrin glue in dural wound repair. Transfusion AABB. 36, 1996.
18. Rieman P. Platelet-rich plasma reduces bleeding, speeds healing. Cosmetic Surgery Times. 38, 2000.
19. Man D, Plosker H, Winland-Brown JE. The use of platelet gel and fibrin glue in cosmetic surgery. Plastic Reconstr Surg.107:229-237, 2001.
20. Clevens RA. Autologous Platelet rich plasma in facial plastic surgery. Proceedings from the 8th International Symposium of Facial Plastic Surgery, 2002.
21. Kerner MM. The use of autologous platelet-gel as an intranasal dressing in functional endoscopic sinus surgery. Presented at the American Rhinologic Society, 2001.
22. Mooar PA, Gardner MJ, Klepchick PR, et al. The efficacy of autologous platelet gel in total knee arthroplasty. Presented at AAOS, 2000.
23. Coetzee JC, Pomerey G, Watts JD. The use of autologous concentrated growth factors in fusion rates in total ankle replacement.American Academy of Orthopeadic Surgeons, 2005.
24. Banco RJ, Kwon B, Jenis LG. Prospective randomized study of autologous growth factors in lumbar fusion clinical/radiographic. American Academy of Orthopeadic Surgeons, 2005.
25. Barrett SL. A new approach to using growth factors in wound healing, 2005.
26. Aminian B, Shams M, Karim-Aghaee B, et al. The role of the autologous platelet derived growth factor in the management of decubitus ulcer, 2003.
27. Barrett SL, Erredge SE. Growth factors for chronic plantar fasciitis? Podiatry Today, 37-42, 2004.
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Published
2012-08-31
How to Cite
Jain, D. P., Jain, D. R., Jain, D. A. K., Jindal, D. M., & Dixit, D. R. (2012). Autologous Platelet Gel and its Clinical application: Autologous Platelet Gel and its Clinical application. National Journal of Integrated Research in Medicine, 3(3), 156–160. Retrieved from http://nicpd.ac.in/ojs-/index.php/njirm/article/view/337
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Review Article
