A Comparative Study Of Reticulocyte Count In Healthy Young Adult And Elderly Age Group Subjects
Study Of Reticulocyte Count In Healthy Young Adult And Elderly
DOI:
https://doi.org/10.70284/njirm.v4i2.2162Keywords:
Aging, Reticulocyte, ElderlyAbstract
Introduction: Aging process has been viewed as progressive decline in physiological process necessary for maintenance of a constant milieu interior and death as the ultimate failure to sustain homeostasis. Reticulocytes are juvenile red cell. It is flat non-nucleated disc shaped, slightly larger than mature erythrocyte .The number of reticulocyte present in the peripheral blood is a fairly accurate reflection of erythropoitic activity of bonemarrow. Normal values in young adult- 0.5 to 2.5% of total RBC count. The present study was conducted to find out changes in the reticulocyte count in the elderly subject. Aims: to uncover the effect of aging on reticulocyte count. Material and method: 90 subjects were divided into two groups, normal control group (n=30, mean age 35.83yrs) and elderly group (n=60, mean age62.55yrs). Reticulocyte counts were done by new Methylene Blue method. Result & Observations: significant decrease in reticulocyte count was observed in elderly group as compare to normal control group. Conclusion: our data suggests that aging may alter haematological parameters including reticulocyte count.
References
2. Jain AK. Physiology of aging, 2001, vol-2,619-622.
3. Palmore, E. Encyclopedia of aging: a comprehensive resource in gerontology and geriatrics; 1995, Pages 914-915, 2nd edition.
4. Ajmani R. S. et al. Hemorheological changes during human aging, gerontology; 1998, 44(2)111-20.
5. Nilsson-Ehle H. Haematology in the aged, sahlgrenska university hospital, goteborg, 2001, Sweden, 208-210.
6. Nilsson-Ehle H, Swolin B, Westin J. Bone marrow progenitor cell growth and karyotype changes in healthy 88-year-old subjects. , 1995, Eur J Haematol; 55:14-8.
7. Edward I. et al. Aging and giriatic medicine: 1992, biology of aging; 2, 212-217.
8. Harmening, Denise. Clinical Hematology and Fundamentals of Hemostasis; 3rd edition, pp. 599-601.
9. Lea and febiger. Values derived from wintrobe MM, clinical hematology; 1993, 9th edition.
10. Henry J. B. Clinical diagnosis and management by laboratory methods; 1996, 19th edition.
11. Kipps T. J. Williams hematology; 1995, 26,518-527, 5th edition.
12. Lee. et al. Wintrobes clinical hematology; 1993, vol-1, 8,321-346, 10th edition.
13. Vellar O D. Studies on hemoglobin values in Norway. IX. Hemoglobin, hematocrit and MCHC values in old men and women, Acta Med Scand; 1967, 182(6):681-9.
14. Van Oosterhout EC. et al. Are hematologic reference values applicable to the healthy elderly, 1989, Ned Tijdschr Geneeskd; 133(18):940-2.
15. Giorno R. et al. Hematology reference values. Analysis by different statistical technics andvariations with age and sex. 1980, Am J Clin Pathol; 74(6):765-70.
16. Ohhara Y. et al. Longitudinal assessment of hematological parameters in the elderly, 1994, Nippon Ronen Igakkai Zasshi; 31(7):548-53.
17. Takubo T, Tatsumi N. Reference values for hematologic laboratory tests and hematologic disorders in the aged, 2000, Rinsho Byori; 48(3):207-16.
18. Suwannuruks R. et al. Hematologic parameters in Thai subjects over 50 years old. 1997, J Med Assoc Thai; 80 Suppl 1:S76-80.
19. Blain H. Determination by flow cytometryof references values of erythrocytes parameters in aged subjects; 2001, 30(16); 779-84.
20. Martin H. et al. Clinical laboratory diagnosis and aging. 3: Evaluation of a study of aging--complete blood and urine status, 2001, Z Gerontol Geriat; 34(3):183-91.