Endometrial Thickness As A Test For Endometrial Cancer In Women With Abnormal Postmenopausal And Perimenopausal Vaginal Bleeding & Its Histopathological Correlation

Endometrial Thickness As A Test For Endometrial Cancer

Authors

  • Col (Dr) P.K. Roy
  • Dr. Pooja Singh
  • Dr. Vijay Kumar Singh
  • Dr. Kalpana Mahadik
  • Dr. Roopam Jain

DOI:

https://doi.org/10.70284/njirm.v4i2.2166

Keywords:

Endometrial thickness, endometrial cancer, abnormalpostmenopausalbleeding

Abstract

Introduction: The menopausal & perimenopausal age are characterized by a deficiency of progesterone and relative hyperestrogenism leading to increased risk of carcinoma endometrium. Transvaginal ultrasonography is used to evaluate the thickness of endometrium in perimenopausal & postmenopausal women presenting with abnormal bleeding per vaginum & its histopathological classification was done. Material & Methods: This retrospective study was carried out in R D Gardi Medical College and Hospital, Ujjain. Seventy five cases were selected from May 2010 - May 2012 and studied in respect to age,parity,socio-economic status, and endometrial thickness in women with abnormal bleeding per vaginum & its relation to histopathology findings of endometrium obtained through D & C. Results:Out of seventy five cases, 49(65.5%) were in perimenopausal age group, and 26(34.5%) in postmenopausal age group. Endometrial thickness greater than 12mm was in 73.4% of perimenopausal and 25.3% of postmenopausal women. In perimenopausal women with abnormal bleeding,histopathology showed‘Benign Hyperplasia’in 51%, ‘Proliferative endometrium’in 26.5%, ‘Secretary endometrium’ in 4.08%, ‘Atrophic endometrium’ in 2.04%, ‘Atypical Hyperplasia’ in 10.2%, andcarcinoma in 6.12%.Whereas in postmenopausal women, Atypical Hyperplasia in 11.4%, carcinoma in 46.12%,benign hyperplasia in 7.6%, proliferative endometrium in 15.33%, secretary endometrium in 7.69%, and atrophic in 11.4%. Conclusion: In majority endometrial thickness by TVS may be helpful in planning investigation protocol and further management

References

1. Williams Textbook of Gynaecology, 2008 edition .
2. Shipley CF 3rd, Simmons CL, Nelson GH. Comparison of transvaginal sonography with endometrial biopsy in asymptomatic postmenopausal women. J Ultrasound Med 1994; 13:99-104.
3. Hanggi W, Bersinger N, Altermatt HJ, Birkhauser MH. Comparison of transvaginal ultrasonography and endometrial biopsy in surveillance in postmenopansal HRT users.Maturitas 1997; 27:133-143.
4. Langer RD, Pierce JJ, O'Hanlan KA, et al. Transvaginal ultrasonography compared with endometrial biopsy for the detection of endometrial disease. Postmenopausal Estrogen/Progestin Intervention Trial. N Engl J Med 1997; 337:1792-1798.
5. Fleischer AC, Wheeler JE, Lindsay I, et al. An assessment of the value of ultrasonographic screening for endometrial disease in postmenopausal women without symptoms. Am J ObstetGynecol 2001; 184:70-75.
6. The Writing Group for the PEPI Trial Effects of hormone replacement therapy on endometrial histology in postmenopausal women. The Postmenopausal,Estrogen/Progestin Interventions (PEPI) Trial.The Writing Group for the PEPI Trial.JAMA. 1996;275:370–5.[PubMed]7. Castelo-Branco C, Puerto B, Duran M, et al. Transvaginal sonography of the endometrium in postmenopausal women: monitoring the effect of hormone replacement therapy. Maturitas 1994; 19:59-65.
8. Paraskevaidis E, Papadimitriou D, Kalantaridou SN, et al. Screening transvaginal uterine ultrasonography for identifying endometrial pathology in postmenopausal women. Anticancer Res 2002; 22:1127-1130.
9. Epplein M, Reed SD, Voigt LF, Newton KW, Holt VL, Weiss NS. Endometrial hyperplasia risk in relation to characteristics and exposures that influence endogenous hormone levels.Am J Epidemiol. 2008.
10. Tavassoli FA. World Health Organization Classification of Tumors: Pathology and Genetics of Tumors of the Breast and Female Genital Organs. IARC Press; Lyon: 2003.
11. Figueroa-Casas PR, Ettinger B, Delgado E, Javkin A, Vieder C. Reversal by medical treatment of endometrial hyperplasia caused by estrogen replacement therapy. Menopause. 2001;8:420–3.
12. Kurman RJ, Kaminski PF, Norris HJ. The behavior of endometrial hyperplasia.A long-term study of “untreated” hyperplasia in 170 patients.Cancer. 1985;56:403–12.

Downloads

Published

2013-04-30

How to Cite

Roy, C. (Dr) P., Singh, D. P., Singh, D. V. K., Mahadik, D. K., & Jain, D. R. (2013). Endometrial Thickness As A Test For Endometrial Cancer In Women With Abnormal Postmenopausal And Perimenopausal Vaginal Bleeding & Its Histopathological Correlation: Endometrial Thickness As A Test For Endometrial Cancer. National Journal of Integrated Research in Medicine, 4(2), 138–142. https://doi.org/10.70284/njirm.v4i2.2166

Issue

Section

Original Articles

Most read articles by the same author(s)

1 2 > >>