Periodontitis And Diabetes Mellitus-A Two Way Relationship
Periodontitis And Diabetes Mellitus-A Two Way Relationship
Keywords:
Periodontal Disease, Diabetes Mellitus, Poor Glycemic Control, AGE’s, InflammationAbstract
Periodontal disease (PD) and diabetes mellitus (DM) hold a consistent relationship. DM not only increases the risk of having PD and with that its prevalence, but it also augments the progression of more aggressive and quickly defining signs. There is a bidirectional relationship between DM and PD. The treatment of periodontitis in diabetic patients favors a reduction in mediators responsible for the destruction of periodontal tissue and decreases with it, resistance to insulin. PD is characterized by low grade chronic inflammation that may remain silent in diabetics causing damage that is not locally limited but may extend systemically. Our aim of this article is to make aware, both general dental and medical practioner about interrelationship between periodontal disease and diabetes with special emphasis on importance of mutual consultation between the two fraternity, which in turn significantly contributes to general well being of an individual.
References
1. Anthony m lacopino-periodontitis and diabetes interrelationship: role of inflammation. Ann periodontology 2001;6:125-137.
2. Löe H. Periodontal disease: the sixth complication of diabetes mellitus. Diabetes Care 1993;16(1):329-334.
3. Offenbacher S, Salvi GE. Induction of prostaglandin release from macrophages by bacterial endotoxin. Clin Infect Dis 1999; 28(3):505-13.
4. Loe H. Periodontal disease. The sixth complication of diabetes mellitus. Diabetes Care 1993; 16(1):329-34.
5. Taylor GW, Borgnakke WS. Periodontal disease: associations with diabetes, glycemic
control and complications. Oral Dis 2008;14(3):191-203.
6. Meltzer S, Leiter L, Daneman D, Gerstein HC, Lau D, Ludwig S, and others. 1998 clinical practice guidelines for the management of diabetes in Canada. Canadian Diabetes Association. CMAJ 1998; 159 (Suppl 8):S1-29.
7. O'Dowd LK, Durham J, McCracken GI, Preshaw PM (2010)
8. Patients' experiences of the impact of periodontal disease. J Clin Periodontol 37:334–339.
9. Pihlstrom BL, Michalowicz BS, Johnson NW (2005) Periodontal diseases. Lancet 366:1809–1820.
10. Grossi SG, Genco RJ, Machtei EE et al (1995) Assessment of risk for periodontal disease. II. Risk indicators for alveolar bone loss. J Periodontol 66:23–29.
11. Zambon JJ, Reynolds H, Fisher JG, Shlossman M, Dunford R Genco RJ. Microbiological and immunological studies of adult periodontitis in patients with non-insulin dependent diabetes mellitus. J Periodontol. 1988; 59: 23–31.
12. Manoucher PM, Spagnuolo PJ, Rodman HM, Bissada NF.Comparison of neutrophil chemotactic response in diabetic patients with mild and severe periodontal disease. J Periodontal. 1981; 52: 410–5.
13. McMullen JA, Van Dyke TE, Horoszewicz HU, Genco RJ. Neutrophil chemotaxis in individuals with advanced periodontal disease and a genetic predisposition to diabetes mellitus. J Periodontol. 1981; 52: 167–73.
14. Mealey BL, Ocampo GL. Diabetes mellitus and periodontal disease. Periodontol 2000. 2007; 44: 127–53.
15. Mealey B. Diabetes and periodontal diseases. J Periodontol 1999; 70: 935–49.
16. Festa A, D’Agostino RDJ, Howard G, Mykkanen I,Tracy RP, Haffner SM. Chronic subclinicalas apart of the insulin resistance syndrome. The insulin resistance atherosclerosis study (IRAS). Circulation. 2000; 102: 42–7.
17. Salvi GE, Collins JG, Yalda B, Arnold RR, Lang NP, Offenbacher S. Monocytic TNF-a secretion patterns in IDDM patients with periodontal diseases. J Clin Periodontol. 1997; 24: 8–16.
18. Naguib G, Al-Mashat H, Desta T, Graves D. Diabetes prolongs the inflammatory response to a bacterial stimulus through cytokine dysregulation. J Invest Dermatol. 2004; 123: 87–92.
19. Lalla E, Lamster IB, Drury S, Fu C, Schmidt AM: Hyperglycemia, glycoxidation and receptor for advanced glycation endproducts: potential mechanisms underlying diabetic complications, including diabetes associated periodontitis. Periodontology 2000, 2000; 23(1): 50–62.
20. Frantzis TG, Reeve CM, Brown AL(Jr): The ultrastructure of capillary basement membranes in the attached gingival of diabetic and nondiabetic patients with periodontal disease. Journal of Periodontology,1971;42(7):406 -411.
21. Listgarten MA, Ricker FH Jr, Laster L, Shapiro J, Cohen DW: Vascular basement lamina thickness in the normal and inflamed gingiva of diabetics and non-diabetics Journal of Periodontology 1974; 45(9):676-684.
22. Seppälä B, Sorsa T, Ainamo J: Morphometric analysis of cellular and vascular changes in gingival connective tissue in long-term insulin-dependent diabetes. Journal of Periodontology, 1997; 68(12): 1237 – 1245.
23. Ramamurthy NS, Golub LM: Diabetes increases collagenase activity in extracts of rat gingiva and skin. Journal of Periodontal Research, 1983; 18(1): 23-30.
24. Ryan ME, Ramamurthy S, Golub LM: Matrix metalloproteinases and their inhibition in periodontal treatment. Current Opinion in Periodontics, 1996; 3:85-96.
25. Page RC, Offenbacher S, Schroeder HE, Seymour JG, Kornman KS. Advances in the pathogenesis of periodontitis: Summary of developments, clinical implications and future
directions. Periodontol 2000. 1997; 14: 216–48.
26. Papapanou PN. Epidemiology of periodontal diseases: An update.J Int Acad Periodontol. 1999; 1: 110–6.
27. American Academy of Periodontology. Diabetes and periodontal diseases (position paper). J Periodontol.1999; 70: 935–49.
28. Sastrowijoto S, Hillemans P, van Steenbergen T, Abraham-Inpijn L, de Graaff J. Periodontal condition and microbiology of healthy and diseased periodontal pockets in Type 1 diabetes mellitus patients. J Clin Periodontol. 1989; 16: 316–22.
29. Taylor GW, Burt BA, Becker MP, Genco RJ, Shlossman M, Knowler WC, Pettitt DJ: Severe periodontitis and risk for poor glycemic control in patients with non-insulindependent diabetes mellitus. Journal of Periodontology, 1996; 67(Suppl 10): 1085 – 1093.
30. Miller LS, Manwell MA, Newbold D, Reding ME, Rasheed A, Blodgett J, Kornman KS: The relationship between reduction in periodontal inflammation and diabetes control: a report of 9 cases. Journal of Periodontology, 1992; 63(10): 843-848.
31. Yki-Järvinen H, Sammalkorpi K, Koivisto VA, Nikkilä EA: Severity, duration, and mechanisms of insulin resistance during acute infections. Journal of Clinical Endocrinology and Metabolism, 1989; 69(2): 317-323.
32. Noack B, Genco RJ, Trevisan M, Grossi S, Zambon JJ, De Nardin E: Periodontal infections contribute to elevated systemic C-reactive protein level. Journal of Periodontology, 2001;72(9):12211227.
33. Salvi GE, Collins JG, Yalda B, Arnold RR, Lang NP, Offenbacher S: Monocytic TNF alpha secretion patterns in IDDM patients with periodontal diseases. Journal of Clinical Periodontology, 1997; 24(1): 8-16.
34. Ling PR, Bistrian BR, Mendez B, Istfan NW: Effects of systemic infusions of endotoxin, tumor necrosis factor, and interleukin-1 on glucose metabolism in the rat: relationship to endogenous glucose production and peripheral tissue glucose uptake. Metabolism, 1994;43(3):279-284.
35. Iwamoto Y, Nishimura F, Nakalgawa M, Sugimoto H, Shikata K, Makino H, Fukuda T, Tsuji T, Iwamoto M, Murayama Y: The effect of antimicrobial periodontal treatment on circulating tumor necrosis factor-alpha and glycated hemoglobin level in patients with type 2 diabetes. Journal of Periodontology, 2001; 72(6):774-778
2. Löe H. Periodontal disease: the sixth complication of diabetes mellitus. Diabetes Care 1993;16(1):329-334.
3. Offenbacher S, Salvi GE. Induction of prostaglandin release from macrophages by bacterial endotoxin. Clin Infect Dis 1999; 28(3):505-13.
4. Loe H. Periodontal disease. The sixth complication of diabetes mellitus. Diabetes Care 1993; 16(1):329-34.
5. Taylor GW, Borgnakke WS. Periodontal disease: associations with diabetes, glycemic
control and complications. Oral Dis 2008;14(3):191-203.
6. Meltzer S, Leiter L, Daneman D, Gerstein HC, Lau D, Ludwig S, and others. 1998 clinical practice guidelines for the management of diabetes in Canada. Canadian Diabetes Association. CMAJ 1998; 159 (Suppl 8):S1-29.
7. O'Dowd LK, Durham J, McCracken GI, Preshaw PM (2010)
8. Patients' experiences of the impact of periodontal disease. J Clin Periodontol 37:334–339.
9. Pihlstrom BL, Michalowicz BS, Johnson NW (2005) Periodontal diseases. Lancet 366:1809–1820.
10. Grossi SG, Genco RJ, Machtei EE et al (1995) Assessment of risk for periodontal disease. II. Risk indicators for alveolar bone loss. J Periodontol 66:23–29.
11. Zambon JJ, Reynolds H, Fisher JG, Shlossman M, Dunford R Genco RJ. Microbiological and immunological studies of adult periodontitis in patients with non-insulin dependent diabetes mellitus. J Periodontol. 1988; 59: 23–31.
12. Manoucher PM, Spagnuolo PJ, Rodman HM, Bissada NF.Comparison of neutrophil chemotactic response in diabetic patients with mild and severe periodontal disease. J Periodontal. 1981; 52: 410–5.
13. McMullen JA, Van Dyke TE, Horoszewicz HU, Genco RJ. Neutrophil chemotaxis in individuals with advanced periodontal disease and a genetic predisposition to diabetes mellitus. J Periodontol. 1981; 52: 167–73.
14. Mealey BL, Ocampo GL. Diabetes mellitus and periodontal disease. Periodontol 2000. 2007; 44: 127–53.
15. Mealey B. Diabetes and periodontal diseases. J Periodontol 1999; 70: 935–49.
16. Festa A, D’Agostino RDJ, Howard G, Mykkanen I,Tracy RP, Haffner SM. Chronic subclinicalas apart of the insulin resistance syndrome. The insulin resistance atherosclerosis study (IRAS). Circulation. 2000; 102: 42–7.
17. Salvi GE, Collins JG, Yalda B, Arnold RR, Lang NP, Offenbacher S. Monocytic TNF-a secretion patterns in IDDM patients with periodontal diseases. J Clin Periodontol. 1997; 24: 8–16.
18. Naguib G, Al-Mashat H, Desta T, Graves D. Diabetes prolongs the inflammatory response to a bacterial stimulus through cytokine dysregulation. J Invest Dermatol. 2004; 123: 87–92.
19. Lalla E, Lamster IB, Drury S, Fu C, Schmidt AM: Hyperglycemia, glycoxidation and receptor for advanced glycation endproducts: potential mechanisms underlying diabetic complications, including diabetes associated periodontitis. Periodontology 2000, 2000; 23(1): 50–62.
20. Frantzis TG, Reeve CM, Brown AL(Jr): The ultrastructure of capillary basement membranes in the attached gingival of diabetic and nondiabetic patients with periodontal disease. Journal of Periodontology,1971;42(7):406 -411.
21. Listgarten MA, Ricker FH Jr, Laster L, Shapiro J, Cohen DW: Vascular basement lamina thickness in the normal and inflamed gingiva of diabetics and non-diabetics Journal of Periodontology 1974; 45(9):676-684.
22. Seppälä B, Sorsa T, Ainamo J: Morphometric analysis of cellular and vascular changes in gingival connective tissue in long-term insulin-dependent diabetes. Journal of Periodontology, 1997; 68(12): 1237 – 1245.
23. Ramamurthy NS, Golub LM: Diabetes increases collagenase activity in extracts of rat gingiva and skin. Journal of Periodontal Research, 1983; 18(1): 23-30.
24. Ryan ME, Ramamurthy S, Golub LM: Matrix metalloproteinases and their inhibition in periodontal treatment. Current Opinion in Periodontics, 1996; 3:85-96.
25. Page RC, Offenbacher S, Schroeder HE, Seymour JG, Kornman KS. Advances in the pathogenesis of periodontitis: Summary of developments, clinical implications and future
directions. Periodontol 2000. 1997; 14: 216–48.
26. Papapanou PN. Epidemiology of periodontal diseases: An update.J Int Acad Periodontol. 1999; 1: 110–6.
27. American Academy of Periodontology. Diabetes and periodontal diseases (position paper). J Periodontol.1999; 70: 935–49.
28. Sastrowijoto S, Hillemans P, van Steenbergen T, Abraham-Inpijn L, de Graaff J. Periodontal condition and microbiology of healthy and diseased periodontal pockets in Type 1 diabetes mellitus patients. J Clin Periodontol. 1989; 16: 316–22.
29. Taylor GW, Burt BA, Becker MP, Genco RJ, Shlossman M, Knowler WC, Pettitt DJ: Severe periodontitis and risk for poor glycemic control in patients with non-insulindependent diabetes mellitus. Journal of Periodontology, 1996; 67(Suppl 10): 1085 – 1093.
30. Miller LS, Manwell MA, Newbold D, Reding ME, Rasheed A, Blodgett J, Kornman KS: The relationship between reduction in periodontal inflammation and diabetes control: a report of 9 cases. Journal of Periodontology, 1992; 63(10): 843-848.
31. Yki-Järvinen H, Sammalkorpi K, Koivisto VA, Nikkilä EA: Severity, duration, and mechanisms of insulin resistance during acute infections. Journal of Clinical Endocrinology and Metabolism, 1989; 69(2): 317-323.
32. Noack B, Genco RJ, Trevisan M, Grossi S, Zambon JJ, De Nardin E: Periodontal infections contribute to elevated systemic C-reactive protein level. Journal of Periodontology, 2001;72(9):12211227.
33. Salvi GE, Collins JG, Yalda B, Arnold RR, Lang NP, Offenbacher S: Monocytic TNF alpha secretion patterns in IDDM patients with periodontal diseases. Journal of Clinical Periodontology, 1997; 24(1): 8-16.
34. Ling PR, Bistrian BR, Mendez B, Istfan NW: Effects of systemic infusions of endotoxin, tumor necrosis factor, and interleukin-1 on glucose metabolism in the rat: relationship to endogenous glucose production and peripheral tissue glucose uptake. Metabolism, 1994;43(3):279-284.
35. Iwamoto Y, Nishimura F, Nakalgawa M, Sugimoto H, Shikata K, Makino H, Fukuda T, Tsuji T, Iwamoto M, Murayama Y: The effect of antimicrobial periodontal treatment on circulating tumor necrosis factor-alpha and glycated hemoglobin level in patients with type 2 diabetes. Journal of Periodontology, 2001; 72(6):774-778
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Published
2013-10-31
How to Cite
Kothari, D. S., Patel, D. V., Panchal, D. A., Mehta, D. H., & Nanavati, D. B. (2013). Periodontitis And Diabetes Mellitus-A Two Way Relationship: Periodontitis And Diabetes Mellitus-A Two Way Relationship. National Journal of Integrated Research in Medicine, 4(5), 92–99. Retrieved from http://nicpd.ac.in/ojs-/index.php/njirm/article/view/601
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