Histopathological spectrum of non- neoplastic and neoplastic lesions of lymph nodes: A retrospective and prospective study
Histopathological spectrum of non- neoplastic and neoplastic lesions of lymph nodes
DOI:
https://doi.org/10.70284/njirm.v9i5.2412Keywords:
Lymphadenopathy, Biopsy, Lymphomas, Granulomatous lymphadenitisAbstract
Introduction: Lymphadenopathy is a clinical manifestation of regional or systemic diseases and signifies as an excellent clue to the important hidden disease. Lymph node biopsies are usually done to know the etiology of lymphadenopathy, which may be neoplastic and non-neoplastic. The neoplastic disorders are mainly lymphohematogenous malignancies and metastases while the causes of non-neoplastic lymphadenopathy are more varied such as infections (bacterial, viral, fungal), drug reactions
Material and Methods: This was retrospective and prospective study in a tertiary care hospital where lymph node biopsies of 100 patients were analysed. For retrospective study, the archived slides and blocks were retrieved for duration of 5 years from September 2011 to August 2015. For prospective study lymph node biopsy specimens of all indoor and outdoor patients received in Department of pathology from September 2015 to August 2017 were included.
Results: Age of patients, ranged from 1 years to 74 years with maximum number of patients in the third decade, followed by second and fourth decade of life, with a male to female ratio of 1.08:1. Of 100 lymph node biopsies analysed, 85 patients had non- neoplastic pathology while 15 patients had neoplastic lesions.
Conclusion: In our study non – neoplastic causes vastly out numbered neoplastic pathologies. Among non-neoplastic, the most frequent cause of lymphadenopathy was reactive hyperplasia. Neoplasic causes included lymphoma and metastatic malignancies. Lymph node biopsy plays an important role in establishing the cause of lymphadenopathy
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