Prevalence of HIV, Hepatitis B and Hepatitis C infection in Thalassemia major patients in tertiary care hospital, Gujarat.

Prevalence of HIV, Hepatitis B and Hepatitis C in Thalassemia

Authors

  • Hardik Bhavsar
  • Kanu Patel
  • Mahendra Vegad
  • Molly Madan
  • Anita Pandey
  • Ashish Asthana
  • Kalpesh Mistry

Keywords:

HIV, Hepatitis B, Hepatitis C, Thalassemia

Abstract

Background: Children suffering from beta thalassemia major, due to various genetic defects, have deficient synthesis of ß globin chain of Hemoglobin. This leads to severe anemia, general fatigue and debility asking for repeated or frequent blood transfusion. On the other hand repeated blood transfusions such expose them to dangerous infections such as HIV, HBV and HCV. Aim: The aim of this study was to determine the prevalence of HIV, HBV and HCV infection among thalassemia major patients in an apex tertiary care hospital of Gujarat in west India. Materials and methods: Data were obtained from 100 ß thalassemia major patients attending thalassemia clinic for blood transfusion at regular interval in an apex tertiary care hospital of Gujarat between April 2008 and September 2008. Their laboratory results were subsequently analyzed. Results: Out of 100 patients 65 and 35 were male and female respectively. 18 (18%) patients were found Anti HCV Ab positive, 6 (6%) were found HBsAg positive and 9(9%) patients were Anti HIV 1 and or 2 Ab positive. Older age, more number of transfusions were associated with increased chances of the test to come positive suggestive of infection with respective virus. Completion of vaccination against HBV, completely or partially, was associated with less chances getting infection with HBV Conclusion: The prevalence of HCV infection is much higher compared to HBV and HIV infection due to possibly infected blood transfusion among thalassemia major patients. Screening of Anti HCV Ab detection with highly sensitive and specific test for donated blood is mandatory. Techniques like P24 Antigen detection or RT-PCR should be introduced to shorten the window period for detection of HIV infected donated blood.

References

1. Patel J, Patel A, Patel J, Kaur A, Patel V. Prevalence of haemoglobinopathies in Gujarat,India: A cross-sectional study. Int J Hematol. 2009;5:1.
2. Parikh SB, Parikh BJ, Shah CK, Shah NR. Analytical profile of seroprevalence of HIV, Hepatitis B and Hepatitis C amongst voluntary and replacement blood donors-a 6 years study. Gujarat M J.2006;1:29–33.
3. Balgir RS. The burden of hemoglobinopathies in India and the challenges ahead. Curr Sci.2000;79:1536–47.
4. Agrawal MB, Malkan GH, Bhave AA, Vishwanathan C, Billa V, Dube SR, et al. Antibody to Hepatitis C virus in multi-transfused thalassemics-Indain experience. J Assoc Physicians India. 1993;41:195–7.
5. Arankalle VA, Chadha MS, Jha J, Amrapurkar DN, Banerjee K. Prevalence of anti-HCV antibodies in western India. Indian J Med Res. 1995;101:91–3.
6. Jaiswal SP, Chitnis DS, Jain AK, Inamdar S, Porwal A, Jain SC. Prevalence of hepatitis viruses among multi-transfused homogenous thalassaemia patients. Hepatol Res. 2001; 19:247–53.
7. Verma IC, Choudhury VP, Jain PK. Prevention of thalassemia: A necessity in India. Indian J Pediatr. 1992;59:649–54.
8. Jaju N.- HIV seropositiviy in multitransfused thalassemics during window period in Mumbai – Int. conf. AIDS 1998. 12 : 393
9. M.Al. Sheyaab. A Batiecha et al. Prevalence of HBV, HCV, HIV in multitransfused Pts – Lab medicine, Jordon University hospital, Amman, Jordon.
10. T N Williams, B wonke et al. A study of HBV, HCV prevalence and liver function in thalassemia patients and parents I J paed. Sep. 1992 Vol. 29. 1119-24
11. Choudhary N, Naik S et al.- High frequency of TTTIS in thalassemia patients- I. J. Hematology and blood transfusion 1995 P. 115-18
12. Shah SMA, Khan MT, et al. Prevalence of HBV and HCV in multitransfused thalassemia – Pakistan Journal of medical science Jul-Sep . 2005. Vol 21.
13. Shaharam M. et al – Epidemiology of HBV, HCV, HIV in pts. with beta thalassemia major – in Iran a multicentric study. – Archieves of Internal medicine Vol 9. 2006.319-23

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Published

2011-09-30

How to Cite

Bhavsar, H., Patel, K., Vegad, M., Madan, M., Pandey, A., Asthana, A., & Mistry, K. (2011). Prevalence of HIV, Hepatitis B and Hepatitis C infection in Thalassemia major patients in tertiary care hospital, Gujarat.: Prevalence of HIV, Hepatitis B and Hepatitis C in Thalassemia. National Journal of Integrated Research in Medicine, 2(3), 47–50. Retrieved from http://nicpd.ac.in/ojs-/index.php/njirm/article/view/1920

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