Study Of Effectiveness Of Pulse Therapy In Various Autoimmune Dermatoses
Study Of Effectiveness Of Pulse Therapy In Various Autoimmune Dermatoses
Keywords:
Pulse Therapy, Pemphigus, Systemic Sclerosis, Systemic Lupus Erythematosus, Mixed Connective Tissue DiseaseAbstract
Background: Autoimmune dermatoses are the disorders of immune systems in which auto antibodies are being generated against own cells. Many therapeutic measures are available but none is highly efficacious as well as free of side effects. Objective: To evaluate the effectiveness of different regimens and modifications of pulse therapy in various autoimmune dermatoses. Methods: We have selected the patients consecutively, according to inclusion criteria, after informed written consent, and divided into fourgroups (1) pemphigus vulgaris (PV) (2) systemic sclerosis (SS) (3) systemic lupus erythematosus (SLE) (4) mixed connective tissue disease (MCTD).Various modified pulse regimens were given according to the disease entity. Monitoring of pulse therapy was done by investigating before and after the pulse.Other immunomodulator drugs and supportive treatments were given. Overall evaluation was done every three monthly. Results:Total21 patients were enrolled for this study of two years duration, which included 09 patients ofpemphigusvulgaris, 03 patients of pemphigus foliaceous,05 patients of systemic sclerosis,02 patients of systemic lupus erythematosus and 02 patients of mixed connective Tissue disease. Different scales were used for evaluation of different entities. According to patient satisfaction score, we found excellent response in cases of systemic sclerosis and mixed connective tissue disease, while good in cases of pemphigus and SLE. Conclusion: Modifications of original pulse therapy in pemphigus vulgarisand use of regimens other than DCPin connective tissue disease are highlyeffective. [Maitri S NJIRM 2017; 8(3):81-88]
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