Estimation Of Serum Î’2-Microglobulin In Oral Precancerous Lesions And Oral Squamous Cell Carcinoma
Estimation of serum β2-microglobulin in oral precancerous lesions and oral squamous cell carcinoma
Keywords:
β2 microglobulin, ELISA, leukoplakia; Oral squamous cell carcinomaAbstract
Background & objectives:The purpose of this study was to assess the serum levels of β2 microglobulin in oral squamous cell carcinoma and oral leukoplakia and to evaluate the possible role of β2 microglobulin as a biochemical parameter in the diagnosis of oral cancer.Methods: Serum β2 microglobulin levels were evaluated using ELISA in thirty patients with oral squamous cell carcinoma, thirty patients with oral leukoplakia, and thirty age-&sexmatched disease-free controls.Results: It was observed that there was a significant increase in serum β2 microglobulin levels in oral squamous cell carcinoma patients as compared to oral leukoplakia and controls. Progressively higher values were obtained as the cancer advanced clinically with respect to clinical staging, tumor size and nodal status. Although, serum β2 microglobulin levels were increased in oral leukoplakia compared to controls, it was found to be statistically insignificant.Interpretation & conclusion: From these results, it seems that evaluation of serum β2 microglobulin levels may be useful as one of the battery of tests in assessment of oral carcinoma and leukoplakia. [Pratik Rupakar NJIRM 2016; 7(4):51-55]
References
2:- Daftary D.K, Murti P.R. and Bhonsle R.B.: Oral Squamous cell carcinomas. In: Prabhu SR, Wilson DF, Daftary DK et al eds. Oral diseases in the tropics. Oxford medical publications, Oxford, 1992. pp 429-58.
3:- Moore, S.R, Johnson, N.W, Pierce A.M. and Wilson D.F.: The epidemiology of mouth cancer: a review of global incidence. Oral Diseases 2000; 6:65-74.
4:- Burkhardt A.: Advanced methods in the evaluation of premalignant lesions and carcinomas of the oral mucosa. J of Oral Pathol1985 ; 14:751-778.
5:- Kinnari B. R, Prabhudas S. P, Jyothi G. C, and Raksha M. S.:Clinical significance of total & Lipid bound sialic acid levels in oral precancerous conditions & oral cancer .J of Oral Pathol& Med 2005;34(5): 263-67.
6:- Mehta. F.S., and Hamner.J.E.: In: Introduction :Tobacco-related oral mucosal lesions and conditions in India. Tata Institute of Fundamental Research, Bombay. First Edition.
7:- Reibel J.: Prognosis of oral premalignant lesions: significance of clinical histopathological, and molecular biological characteristics. Crit Rev Oral Biol Med. 2003; 14(1): 47-62.
8:- Daniel W. Chan and Steward Sell.: In: Tumor markers: Comprehensive text book of Oncology. Williams and Wilkins publications. London: 1986; First Edition.
9:-VaishaliN, and Tupkari J.V.: An estimation of serum β2- microglobulin level in premalignant lesions/conditions and oral squamous cell carcinoma: a clinicopathological study. J of Oral Pathol 2005; 9(1):16-19.
10:- Krishnakumar, S., et al.: Human Leukocyte Class I Antigen and [beta]2- Microglobulin Expression in Conjunctival Dysplasia, Carcinoma In Situ, and Squamous Cell Carcinoma 2005 ;Cornea 24(3); 337-341.
11:- Silvia C.R.W.D, Vasudevan D.M, and SudhakarPrabhu K.: Alteration of serum β2 Microglobulin in oral carcinoma. Ind J of ClinBiochem 2002; 17(2):104-107.
12:- Neville B.W, Damm D.D, Allen C.M. and Bouquot J.E.: Oral & Maxillofacial Pathology. Second Edition. W.B. Saunders Company. 2000: pp356-367.
13:- Shankaranarayanan R. et al.: A case control investigation of cancer of the oral tongue and the floor of the mouth in Southern India. Int J of Cancer 44:617 vide ref no.26.
14:- Mathew B.: Epidemiology of Oral cancer. JIDA 1993; 64: 43-45.
15:- Kithier K et al.: β2-microglobulin: Occurrence in fetal life and malignancy. Clin. Chim. Acta.1974; 52:293-99.
