Detection and Utility of CRP in Neonatal Patients as an Early Marker
Detection and Utility of CRP in Neonatal Patients as an Early Marker
Keywords:
CRP, Early detection, NeonatesAbstract
Background &Objectives:1) Detection of CRP in neonatal patients.2) Analyzing and utility of CRP as an early marker to decrease the mortality and morbidity among neonates.Methods: This is retrospective study spanning from 01.05.2016 to 31.08.2016. Serum sample of neonates with clinical features of tachypnoea, tachycardia, hypotonia, oliguria and poor responsiveness etc. were sent to the laboratory for CRP testing by the clinicians. A total of 5870 serum samples of neonates were tested for CRP by using RECKON DIAGNOSTIC KIT based on latex agglutination, those which tested positive were subjected to determination of titre. RESULT:A total 5870 neonatal samples were received out of which 4340 (73.93%) tested positive. Titre of positive samples ranged from 0.6 mg/dl to 19.2mg/dl. Interpretation&Conclusion: CRP has high sensitivity and specificity for establishing the diagnosis of neonatal diseases and can be taken as an early marker. It is preferable to other markers viz, IL-2, IL-6, INF Gamma, TNF-alfa, and Cytokines because of its low-cost benefit, easy availability and convenient testing methods. It is also better than culture methods like blood culture because of early result availability. Therefore it can be used commonly for early detection of neonatal conditions.[Sarita NJIRM 2017; 8(2):59-61]
References
2. PovoaP C-reactive protein : a valuable marker of sepsis intensive care unit 2002 :28 (3):235-243.
3. Roy I, Jain A ,Kumar M, A Agrawal SK , Bacteriology of neonatal septicemia in tertiary care hospital of Northern India, Indian J Med Microbial (2002)20(3):156-159.
4. Ng PC Diagnosis marker of infection in neonates Arch Dis Child Fetal Neonatal Ed 2004 :89(3):F 229-F235.
5. Laxmi N Gururaj K A C-Reactive protein in neonatal septicemia.Indian J Med Microbial . 1992:10, 29-31.
6. GhaiOP , Gupta P , Paul VK , Ghai essential pediatric , 6th ED. New Delhi.: CBS Publisher and Distributors:2008.
7. De A ,Saraswati K ,Gogate A , Raghavan K. C –Reactive protein and buffy coat smear in early diagnosis of childhood septicemia . Indian J Pathol Microbial .1998:41 (1):23;26.
8. Tsering DC Chanchal L, Pal R ,Kar,S Bacteriological profile of septicemia and risk factor in Neonates and Indian in SIKKIM . J Glob infects Dis . 2011:3(1):42-5.
9. SrramR . Correlation of blood culture results in the sepsis score and sepsis screen in the diagnosis of neonatal septicemia. Int J Biol Med Res .2011;2(1):360-368.
10. Bhattacharya S Blood culture in India:a proposal for a national program for early detection of sepsis . Indian J Medical Microbial :23 (4)220-6.
