Prevalence of Inducible Clindamycin Resistance in Isolates Staphylococcus Aureus from Various Clinical Specimen At Tertiary Care Centre
Prevalence Of Inducible Clindamycin Resistance In Isolates Staphylococcus Aureus
Keywords:
D test, MRSA, Staphylococcus aureusAbstract
Introduction: Staphylococcus aureus cases a variety of infections to skin and soft tissue infections to life threatening endocarditis. Therapeutic failure to Clindamycin has been reported due to mechanisms which confer resistance consitutively, or by the presence of low level inducers which can lead to therapeutic failure. Method: The present study January 2016 to 2016 November total 866 isolates of Staphylococcus aureus isolates from various specimens like pus, blood, fluids, wound swab and urine were tested. Antimicrobial susceptibility testing were done by Kirby Bauer’s disc diffusion method .Inducible Clindamycin resistance was tested by Clindamycin disc induction test (D test) as per CLSI recommendations .Results: In present study was from January 2016 to November 2016 total sample 34,126 from their total 866 Staphylococcus aureus obtained from concecutive cilnical specimens were included, consisting of 97(11.2%) MRSA and 769(88.79%) MSSA. These isolates were subjected to D 121(13.97%) out of 866 Staphylococcus aureus Resistance showed Clindamycin 258(36%) and Erythromycin 453(63.44%).Sensitivity of Clindamycin 584(81.5%) and Erythromycin 423(59.2%). Conclusion: The D test is a simple effective and an important method for the phenotyping detection of inducible clindamycin resistance and it should be used routinely as it will help in guiding the empirical therapy. [Bhoya J NJIRM 2017; 8(2):39-43]
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