Prevalence of Candidemia in A Tertiary Care Hospital, Ahmedabad
Prevalence of Candidemia in a Tertiary Care Hospital, Ahmedabad
Keywords:
Antifungal Susceptibility, Blood Culture, CandidemiaAbstract
Background and Objectives: Candida species are the most common cause of fungal infections responsible for superficial, mucocutaneous, and invasive infections. To find out the prevalence of candidemia and antifungal susceptibility pattern of Candida isolates and various risk factors. Materials and Methods: All Candida isolates from blood culture were included in the six months study period from April to September-2016. The isolates were identified by using various phenotypic tests like germ tube test, corn meal agar, carbohydrates assimilation and fermentation tests. The species were also confirmed on chrome agar. Antifungal susceptibility testing was done by disc diffusion methods according to current Clinical and Laboratory Standard Institute (CLSI) guidelines. Results: Out of 3686 Blood Samples, 2048(55.56%) were culture positive. 129(6.29%) of the isolates were Candida species. Most common species identified was Candida parapsilosis. Most isolates were sensitive to Amphotericin B. 21.89% of isolates from blood were azole resistant. Conclusion: Candidemia is emerging as a significant problem in hospitalized patients, especially in ICU setups. Non-albicans Candida species are the major cause of candidemia as found in our study. Multicentric studies are required to know the true prevalence of candidemia and the status of antifungal drug resistance among Candida isolates. [Mistry U NJIRM 2017; 8(2):143-145]
References
2. Asmunds Dottir L.R., Erlends Dottir H., Gott Fredsson M. Increasing incidence of Candidemia: Results from a 20 – Year Nationwide study in Iceland. J Clin Microbiol 2002;40:3489â€92
3. Wise G.J., Silver D.A. Fungal Infections of the Genitourinary System. J Urol 1993; 149:1377â€88.
4. Fraser V.J., Jones M., Dunkel J., et al. Candidemia in Tertiary care Hospital: Epidemiology, Risk Factors and Predictors of mortality. Clin Infect Dis 1992; 15:414â€21.
5. Person ML;Hospital Infection Control Practices Advisorytions Surveillance System. Secular trendsin the epidemiol-Comimittee. Guideline for prevention of intravascular de-ogy of nosocomial fungal infections in the United States.vice-related infections.Infect Control Hosp Epidemiol. J Infect Dis. 1993;167:1247-1251.1996;17:438-473.
6. Kao AS, Brandt ME, Pruitt WR, et al. The epidemiology of Mermel LA, Farr BM, Sheretz RJ, et al. Guidelines for the candidemia in 2 United States cities: results of a popula-management of intravascular catheter-related infection-based active surveillance. Clin Infect Dis. 1999; 29: Clin Infect Dis.2001;32:1249-1272.1164-1170.
7. Bodey GP Anaissie EJ, Edwards JE Jr. Definitions of Can-Girmenia CP, Martino F, De Bernadis G, et al. Rising inci-dida infections [appendix]. Candidiasis: Incidence of Candida parapsilosis fugemia in patients with Pathogenesis, clinical aspects, predisposing factors and differential pathogenicity of the causative of fungal infections in the 1990s. Eur J Clin Microbiol Infect Press;1993:407-408.
8. Gonza´lez GM, Elizondo M, Ayala J. Trends in species distribution and susceptibility of blood stream isolates of Candida collected in Monterrey, Mexico, to seven antifungal agents: results of a 3-Year (2004 to 2007) surveillance study. J Clin Microbiol 2008; 46:2902- 2905. 8.
9. Bassetti M, Righi E, Costa A, Fasce R, Molinari MP, Rosso R, et al. Epidemiological trends in nosocomial candidemia in intensive care. BMC Infect Dis 2006; 6:21.
10. Banergee B, Dominic RM, Baligo S. clinic-microbiological study of candidemia in a tertiary care hospital of southern part of India. IRAN J MICROBIOL. 2015; 7(1):55-61.
11. Chander J, Singla N, Sidhu SK, Gombar S. Epidemiology of Candida blood stream infections: experience of a tertiary care Centre in North India. J Infect Dev Ctries 2013; 7(9):670-675.
