Different Treatment Modalities For Drug Induced Gingival Overgrowth: A Case Series
DOI:
https://doi.org/10.70284/njirm.v9i2.2327Keywords:
Amlodipine, Gingivectomy, Gingival hyperplasia, Calcium channel blockers.Abstract
Gingival overgrowth is a well documented adverse effect associated with three major classes of drugs that are, anticonvulsants, calcium channel blockers, and immunosuppressants. Eventhough the anding of pathogenesis of drug induced gingival overgrowth (DIGO) is well understood, its treatment still remains a challenge for the periodontists and treatment is still largely limited to maintenance of improved level of oral hygiene and surgical removal of overgrown tissue. Thus, it is important to discuss this issue with their medical colleagues and to practice care while prescribing the drugs associated with gingival overgrowth. This case series highlights the various treatment modalities for different patients.
References
1. Seymour RA, Ellis JS, Thomson JM. Pathogenesis of drug induced gingival overgrowth. J Clin Periodontol 1996;23:165–175.
2. Jorgensen MG. Prevalence of amlodipine related gingival hyperplasia. J Periodontol 1997;68:676–678.
3. Lafzi A, Farahani RM, Shoja MA. Amlodipine induced gingival hyperplasia. Med Oral Patol Oral Cir Bucal 2006;11:E480–482.
4. Seymour RA, Ellis JS, Thomson JM, Monkman S, Idle JR. Amlodipine induced gingival overgrowth. J Clin Periodontol 1994;21:281- 283.
5. Brown RS, Sein P, Corio R, Bottomley WK. Nitrendipine induced gingival hyperplasia. Oral Surg Oral Med Oral Pathol 1990;70:593-596.
6. Nyska A, Shemesh M, Tal H, Dayan D. Gingival hyperplasia induced by calcium-channel blockers: mode of action. Med Hypotheses 1994;43:115-8.
7. Das SJ, Olsen I. keratinocyte growth factor is upregulated by hyperplasia inducing drug nifedipine. Cytokine 2000;12:1566-1569.
8. Van Der Vleuten CJ, Trijbels-Smeulders MA, Van De Kerkhof PC. Telangiectasia and gingival hyperplasia as side-effects of amlodipine (Norvasc) in a 3-year-old girl. Acta Derm Venereol 1999;79:323-4.
9. Border WA, Noble NA. Transforming growth factor beta in tissue fibrosis. N Engl J Med 1994;331:1286-92.
10. Mavrogiannis M, Ellis JS, Thomason JM, Seymour RA. The management of drug induced gingival overgrowth. J Clin Periodontol 2006;33:434–439.
11. Carranza F, Newman M, Takei H, Klokkevold P. Treatment of gingival enlargement. In: Carranza's Clinical Periodontology. 12th ed. St. Louis, Mo.: Elsevier Saunders. 2012:587-592
2. Jorgensen MG. Prevalence of amlodipine related gingival hyperplasia. J Periodontol 1997;68:676–678.
3. Lafzi A, Farahani RM, Shoja MA. Amlodipine induced gingival hyperplasia. Med Oral Patol Oral Cir Bucal 2006;11:E480–482.
4. Seymour RA, Ellis JS, Thomson JM, Monkman S, Idle JR. Amlodipine induced gingival overgrowth. J Clin Periodontol 1994;21:281- 283.
5. Brown RS, Sein P, Corio R, Bottomley WK. Nitrendipine induced gingival hyperplasia. Oral Surg Oral Med Oral Pathol 1990;70:593-596.
6. Nyska A, Shemesh M, Tal H, Dayan D. Gingival hyperplasia induced by calcium-channel blockers: mode of action. Med Hypotheses 1994;43:115-8.
7. Das SJ, Olsen I. keratinocyte growth factor is upregulated by hyperplasia inducing drug nifedipine. Cytokine 2000;12:1566-1569.
8. Van Der Vleuten CJ, Trijbels-Smeulders MA, Van De Kerkhof PC. Telangiectasia and gingival hyperplasia as side-effects of amlodipine (Norvasc) in a 3-year-old girl. Acta Derm Venereol 1999;79:323-4.
9. Border WA, Noble NA. Transforming growth factor beta in tissue fibrosis. N Engl J Med 1994;331:1286-92.
10. Mavrogiannis M, Ellis JS, Thomason JM, Seymour RA. The management of drug induced gingival overgrowth. J Clin Periodontol 2006;33:434–439.
11. Carranza F, Newman M, Takei H, Klokkevold P. Treatment of gingival enlargement. In: Carranza's Clinical Periodontology. 12th ed. St. Louis, Mo.: Elsevier Saunders. 2012:587-592
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Published
2018-05-16
How to Cite
Mehta, J., Bakutra, G., Chandran, S., & Vishnoi, S. (2018). Different Treatment Modalities For Drug Induced Gingival Overgrowth: A Case Series. National Journal of Integrated Research in Medicine, 9(2), 106–109. https://doi.org/10.70284/njirm.v9i2.2327
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Case Report
