Reticulocyte Count Of Nigerian Children With Malaria Infection In The University Of Calabar Teaching Hospital.
Reticulocyte Count Of Nigerian Children With Malaria Infection
Keywords:
Reticulocytes, Anaemia, MalariaAbstract
Background: This work was sets out to assess the reticulocyte count of Nigerian Children infected with malaria in the University of Calabar Teaching Hospital, comprising of fifty malaria infected children and forty six apparently healthy children. The malaria infected children comprised of 25 males and 25 females aged 1-10 years. Blood samples were collected and analysed for reticulocyte count using the 1% new Methylene Blue supra vital staining method and malaria parasites using, 2% Giemsa stain. The mean reticulocyte count in the malaria infected children (2. 17 ± 0.3%) was significantly higher (P<0.01) than that in the apparently healthy children (1.03 ± 0.3 %). The mean parasites density in infected children was 30,428.76 ± 11,876.85 ul. A comparism of reticulocyte level of infected male (2.204 ± 0.32%) and female children (2.133 ± 0.3 6%) showed no significant difference (p>O.O5). Equally, the reticulocyte levels of infected children between 1-5 years of age (2.1 5 ± 0.34%) was not significantly different (P> 0.05) from that of children aged between 6-10 years (2.18 ± 0.32%). The level of reticulocytosis is a reflection of parasite density in the malaria infected children. [Udomah F et al NJIRM 2015; 6(2):44-48]
References
2. WHO (2001) Malaria Infection Analysis in the topics, case study, Congo Rep. Tropical Med. Hyg. 30:647-649.
3. WHO (2013) World Malaria Risk Chart. Geographical distribution of principal malaria vectors, Plasmodium faciparum drug resistant areas and guidelines for suppressive medication by country. International Association for Medical Assistance to Travellers. Source: http://www.iamat.org, Retrieved on 26th September 2013.
4. Bjorkman, A. Philips, S and Howards, P. A. (1991). Adverse reaction to sulfa drugs; implication s of malaria chemotherapy. Bulletin of the World Health Org. 69: 297-300.
5. Lee S W, Lee S E Chung B H, Hwang T J, Shin H S. (2008). A case of Plasmodium vivax malaria associated with autoimmune hemolytic anemia. Infect Chemother ;40:63-66.
6. Jakesman, G. N., Saul, A. Hogauth, W. L., Collins, W. E. (1999). Anaemia of acute malaria infections in non-immune patients primarilyresult from the destruction of uninfected erythrocyte 37:376-9.
7. White, J. M. (1981) Haemoglobinopathies In: Post Graduate Hematology Hofforand, A.V. and Lewis, S.W. (eds.) pp. 190-228. Williams Heinemann Med Books Ltd, London.
8. Wattana L., Srivicha K., Noppadon T., Gary B. and Sornchai, L. (2008) Defective erythropoietin production and reticulocyte response in acute Plasmodium falciparum malaria-associated anaemia. Southeast Asian J Trop Med Public Health. 3 9(4): 581 D 588.
9. Thompson, R. B. (1979) Evidence of Regeneration in: Short Textbook of Hematology. 5TH ed pp. 109 Pitman Book (publishers) Ltd London WCZ.
10. Vishnu, S., Rohini S., Ashit, H.,and Khushrav, B. (2012) Autoimmunc Hemolysis in Malaria: A Report of Three Cases. Journal of the Association of Physicians of India,60: 51-52
11. Franklin - Bunnet, H., Forget, B. G. and Ranney, H. M. (1997). Anaemia of sickle cell disease in Human Hemoglobin pp 250. W. B. Sanders Company.
12. Jha A, Sayami G, Adhikari RC, Panta AD, Jha R. (2008). Bone marrow examination in cases of pancytopenia. JNepal MedAssoc 47(169):12-7.
13. Hall R. and Malia, R. G. (1984) Reticulocyte counting and PCV by centrifugation in Medical Laboratory Hematology pp 106-107 and 115. Butter Worth & co (Publishes) Ltd London.
14. WHO (1985) Severe and complicated malaria Trans R Soc Tropical Medical Hyg 84: 1-69.
15. Alaribe, A. A. Ejezie, G. C. and Ezedinachi, E. N. U. (2002) Li Studies on mosquito distribution in Ekemkpon village Cross River State of Nigeria, Li Journal of Medical Laboratory Science, 2:45Li51.
16. Halim, N.K.D. and Ajayi, F.O. (2002). Monocytosis in acute malaria infection. Nigerian Journal of Clinical Practice. 5(2):106-108.
17. Preeti J., Roopam J., Chinmay S., Jindal, M. Jam, A. K. Dixit, R. (2013) A Comparative Study Of Reticulocyte Count In Healthy Young Adult And Elderly Age Group Subjects National 1 Journal of Integrated Research in Medicine 4(2): 118-122
18. Ghosh, P. K, Ghosh K. (2007). Pathogenesis of anaemia in malaria: a concise review. ParasitRes 101:1463-1469.
19. Kiran, T. and Bukhari, H. (2013) Reference values of reticulocyte counts in five age groups of healthy infants at Rawalpindi, Pakistan. Journal of the Pakistan Medical Association 63: 1108-1111.
20. Mitchell SL. (2006) Reference ranges and normal values. In: Lewis SM, Bain BJ, Bates I, Dade JV (eds.) Dacie and Lewis Practical Haematology. 8th ed. Edinburgh: Churchill Livingston; pp 13-20.
