Study of Heart Rate Variability in Hypertensive Subjects
Study of Heart Rate Variability in Hypertensive Subjects
Keywords:
Heart Rate Variability, Hypertension, and Autonomic DisturbanceAbstract
Introduction: Hypertension represents a multifactorial disease of blood pressure (BP) regulation with persistently elevated systolic and/or diastolic BP over 140/90mmHg. 90% cases of hypertension have to be assigned as essential hypertension. Research has proven that patients with essential hypertension, especially at an early stage without any medication, display autonomic disturbance in the form of increase in sympathetic and a reduction in parasympathetic activity of the ANS. The heart rate variability analysis is a powerful tool in assessment of the cardiac autonomic nerve function. It is non-invasive, an accurate, reliable, reproducible, yet simple to measure and to process and It is indicative of neuro-cardiac fitness and overall health. Objective – The aim of the present study was to (1) measure Heart rate variability (HRV) in Essential Hypertension (2) effect of different drugs on Heart rate variability in hypertension among hypertensive subjects. Materials and Methods: This study was conducted On 100 Hypertension subjects & 100 Normal subjects after obtaining informed written consent by use of Heart rate variability Analysis System Variowin-HR Medical System. Results: The mean values of Very low frequency (VLF), Low frequency (LF), High frequency (HF), Normalized High Frequency (HF (nu) & all time domain parameters were found to be reduced significantly in hypertensive subjects as compared to control subjects. The mean values of LF (nu), LF / HF ratio were significantly high in hypertensive subjects as compared to control subjects. Conclusion: observations in our study demonstrate that hypertensive subjects had markedly reduced heart rate variability (HRV) in comparison with normal subjects which indicate cardiac autonomic disturbances in hypertension subjects in causation of essential hypertension. [Diwan J NJIRM 2015; 6(1):1-6]
References
2. Kikuya M et al. Prognostic significance of blood pressure and heart rate variabilities: the Ohasama study. Hypertension 2000; 36: 901–906.
3. Malliani A, Pagani M, Lombardi F, Cerutti S. Cardiovascular neural regulation explored in the frequency domain. Circulation 1991; 84: 482-492.
4. Langewitz W, Ru¨ ddel H, Scha¨chinger H. Reduced parasympathetic cardiac control in patients with hypertension at rest and under mental stress. Am Heart J 1994; 127: 122–128.
5. Julius S. Autonomic nervous system dysregulation in human hypertension. Am J Cardiol. 1991;67:3B–7B.
6. Kaplan NM. Primary hypertension: pathogenesis. In: Kaplan NM, ed. Clinical Hypertension. Baltimore, Md: Williams & Wilkins; 1990 55 111.
7. Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology. Heart rate Variability standards of measurement, physiological interpretation, and clinical use. Circulation. 1996;93:1043–1065.
8. Rehnuma Tabassum, Noorzahan Begum, heart rate variability in patientwith essential hypertenson, j bangladesh physiol 2010 june;5(1); 1-7
9. Naslund T., D. J. Silberstein, W. J. Merrell, J. H. Nadeau, and A. J. J. Wood. Low sodium intake corrects abnormality in receptor mediated
arterial vasodilation in patients with hypertension: correlation with -receptor function in vitro. Clin Pharmacol Ther. 1990; 48: 87-95.
10. Stein CM, Nelson R, Deegan R, He H, Wood M, Wood AJJ. Forearm ß -adrenergic receptormediated vasodilation is impaired, without alteration of forearm norepinephrine spillover, in borderline hypertension. J Clin Invest.1995; 96: 579-85.
11. Singh J, Larson M, Tsuji H, Evans J, O’Donnell C and Levy D. Reduced heart rate variability and new-onset hypertension: insights into pathogenesis of hypertension: the Framingham Heart Study. Hypertension.1998; 32: 293- 297.
12. Mohamed Faisal Lutfi, Mohamed Yosif Sukkar Effect of blood pressure on heart rate variability Khartoum Medical Journal (2011) Vol. 04, No. 01, pp. 548 – 553.
13. G. K. Pal, Pravati Pal, Nivedita Nanda, V. Lalitha, T. K. Dutta, and C. Adithan Sympathovagal Imbalance in Prehypertensive Offspring of Two Parents versus One Parent Hypertensive International Journal of Hypertension Volume 2011.
14. Mohd.Urooj, K.K.Pillai, Monika.Tandon, Venkateshan Sp, Nilanjan.Saha, Reference Ranges For Time Domain Parameters Of Heart Rate Variability In Indian Population & Validation In Hypertensive Subjects And Smokers International Journal of Pharmacy & Pharmaceutical Sciences ISSN- 0975-1491 Vol 3, Issue 1, 2011.
15. Hisako Tsuji; Martin G. Larson,; Ferdinand J. Venditti, Emily S,Manders, BS; Jane C.Evans, Charles L. Feldman ;Daniel Levy, Impact of Reduced Heart Rate Variability on Risk for Cardiac Events The Framingham Heart Study.
16. Schroeder E, Liao D, Chambless L, Prineas R, Evans G and Heiss G. Hypertension, Blood Pressure, and Heart Rate Variability. therosclerosis Risk in Communities (ARIC) Study. Hypertension. 2003;42:1106-1111.
17. Antônio da Silva Menezes Júnior, Humberto Graner Moreira, Murilo Tavares Daher Goiânia, GO Analysis of Heart Rate Variability in Hypertensive Patients Before and After Treatment with Angiotensin II- ConvertingEnzyme Inhibitors Brazil Arquivos Brasileiros de Cardiologia – Volume 83, Nº 2, Agosto 2004.
18. Guzzetti S, Piccaluga E, Casati R, Cerutti S, Lombardi F, Pagani M et al , 1988,Sympathetic predominance in essential hypertension: a study employing spectral analysis of heart rate variability. J Hypertens 6:711 717.
