Rare Haemoglobin Variant Hb J Meerut in 27 Years Old Female - A Case Report
Rare Haemoglobin Variant Hb J Meerut In 27 Years Old Female
Keywords:
Hb J Meerut, Alkaline gel electrophoresis, fast moving hemoglobins, Globin genesAbstract
Hemoglobin has plenty of variants and fast moving hemoglobins (FMH’s) are the rare hemoglobin variants. They are having tendency to migrate anodally to hemoglobin A on alkaline gel electrophoresis. Because of the mutation in the globin genes, these hemoglobin variants have the fast moving nature. The basic pathophysiology behind it is the substitution of a negatively charged amino acid residue in either α, β or γ globin chains. Hb J Meerut is an infrequently found α-globin variant. It has previously been reported in various populations around the world. Here, we are reporting a case of Hb J meerut who came to laboratory for thalassemia screening. [Rathod G NJIRM 2014; 5(5):108-110]
References
1. Yalcin A, Avcu F, Beyan C, Gurgey A, Ural AU. A case of Hb J-Meerut (or Hb J-Birmingham) (A 120(H3)Ala–>Glu). Hemoglobin, 1994; 18: 433–435.
2. Yang GY, Wang CF, Liu JB, et al. Hemoglobin J Bangkok in three families and its structural analysis. ActaAcad Med Wuhan, 1984; 4: 124–126.
3. Arribalzaga K, Ricard MP, Carreno DL, et al. Hb J-Baltimore (b 16(A13)Gly–>Asp) associated with b(+)-thalassemia in a Spanish family. Hemoglobin, 1996; 20: 79–84.
4. Thorup OA, Itano HH, Wheby M, Leavell BS. Haemoglobin J. Science, 1956; 123: 889-90.
5. Blackwell RQ, Boon WH, Wang CL, Weng MI, Liu CS. Hemoglobin J Meerut: α120 Ala ->Glu. BiochimBiophysActa., 1974; 351: 7-12.
6. Kamuzora H, Lehmann H, Griffiths KD, Mann JR, Raine DN. A new hemoglobin variant hemoglobin J Birmingham α120 (H3) Ala ->Glu. Ann clinbiochem., 1974; 11: 53-55.
7. Molchanova TP, Pobedimskaya DD, Huisman THJ. The differencs in quantities of α2- and α1-globin gene variants in heterozygotes. Br J Haematol., 1994; 88: 300-306.
8. Harano T, Harano K, Imai K, Yunoki H, Yagi H, Nagashima K, Kuroume T. Hb J-Meerut *α120 (H3) Ala ->Glu] found in a Japanese family. Hemoglobin, 1989; 13(2): 169-175.
9. UpendraSrinivas, ManoranjanMahapatra, H.P. Pati. Hb J Meerut, A Fast-Moving Hemoglobin—A Study of Seven Cases from India and A Review of Literature. American Journal of Hematology, 2007; 82: 666–667.
10. Yagame M, Jinde K, Suzuki D, Saotome N, Takano H, Tanabe R. A diabetic case with hemoglobin J-Meerut and low HbA1C levels. Intern Med, 1997; 36: 351–356.
2. Yang GY, Wang CF, Liu JB, et al. Hemoglobin J Bangkok in three families and its structural analysis. ActaAcad Med Wuhan, 1984; 4: 124–126.
3. Arribalzaga K, Ricard MP, Carreno DL, et al. Hb J-Baltimore (b 16(A13)Gly–>Asp) associated with b(+)-thalassemia in a Spanish family. Hemoglobin, 1996; 20: 79–84.
4. Thorup OA, Itano HH, Wheby M, Leavell BS. Haemoglobin J. Science, 1956; 123: 889-90.
5. Blackwell RQ, Boon WH, Wang CL, Weng MI, Liu CS. Hemoglobin J Meerut: α120 Ala ->Glu. BiochimBiophysActa., 1974; 351: 7-12.
6. Kamuzora H, Lehmann H, Griffiths KD, Mann JR, Raine DN. A new hemoglobin variant hemoglobin J Birmingham α120 (H3) Ala ->Glu. Ann clinbiochem., 1974; 11: 53-55.
7. Molchanova TP, Pobedimskaya DD, Huisman THJ. The differencs in quantities of α2- and α1-globin gene variants in heterozygotes. Br J Haematol., 1994; 88: 300-306.
8. Harano T, Harano K, Imai K, Yunoki H, Yagi H, Nagashima K, Kuroume T. Hb J-Meerut *α120 (H3) Ala ->Glu] found in a Japanese family. Hemoglobin, 1989; 13(2): 169-175.
9. UpendraSrinivas, ManoranjanMahapatra, H.P. Pati. Hb J Meerut, A Fast-Moving Hemoglobin—A Study of Seven Cases from India and A Review of Literature. American Journal of Hematology, 2007; 82: 666–667.
10. Yagame M, Jinde K, Suzuki D, Saotome N, Takano H, Tanabe R. A diabetic case with hemoglobin J-Meerut and low HbA1C levels. Intern Med, 1997; 36: 351–356.
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Published
2018-01-07
How to Cite
Rathod, D. G., Aggarwal, D. S., Goyal, D. R., Patel, D. R., Bhimani, D. R., & Kuchhal, D. N. (2018). Rare Haemoglobin Variant Hb J Meerut in 27 Years Old Female - A Case Report: Rare Haemoglobin Variant Hb J Meerut In 27 Years Old Female. National Journal of Integrated Research in Medicine, 5(5), 109–111. Retrieved from http://nicpd.ac.in/ojs-/index.php/njirm/article/view/813
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Case Report
