Odontogenic Keratocyst- The Controversies in Nomenclature and Treatment Modalities
Odontogenic Keratocyst- The Controversies
Keywords:
Odontogenic Kerotocyst, Keratocystic Odontogenic Tumor, jaw cysts, marsupialization, nucleationAbstract
Summary: Odontogenic keratocysts (OKC) now officially known as Keratocystic odontogenic tumor (KCOT) is a benign odontogenic intraosseous tumor which is potentially agrressive having distinguished clinical and histopathological features. Based on a literature review, more aggressive treatment — either resection or enucleation supplemented with Carnoy’s solution with or without peripheral ostectomy — results in a lower recurrence rate than enucleation alone or marsupialization. WHO’s reclassification of this lesion from cyst to tumour underscores its aggressive nature and should motivate clinicians to manage the disease in a correspondingly aggressive manner. The purpose of this paper is to review and discuss the redesignation of KCOT and the implications for treatment. [Maheta D NJIRM 2014; 5(5):70-76
References
1. Jindrich Pazdera, Zdenek Kolar, Vitezslav Zboril, Peter Tvrdy, Richard Pink: Odontogenic keratocysts/keratocystic odontogenic tumours: biological characteristics, clinical manifestation and treatment; Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2012; 156:XX.
2. M.A. Pogrel: The history of the odontogenic keratocyst; Oral Maxillofacial Surg Clin N Am 15: 2003: 311–315.
3. T.-J. Li: The Odontogenic Keratocyst: A Cyst, or a Cystic Neoplasm?; J Dent Res 90(2):133-142, 2011
4. Jonathan Madras and Henry Lapointe: Keratocystic Odontogenic Tumour: Reclassification of the Odontogenic Keratocyst from Cyst to Tumour; JCDA March 2008, Vol. 74, No. 2
5. Dolphine Oda, Valiente Rivera, N. Ghanee, E. A. Kenny, K. H. Dawson: Odontogenic Keratocyst: The Northwestern USA Experience; The Journal of Contemporary Dental Practice, Volume 1, No. 2, Winter Issue, 2000
6. P.J.W. Stoelinga: Etiology and pathogenesis of keratocysts; Oral Maxillofacial Surg Clin N Am 15 (2003) 317–324
7. Chirapathomsakul, Sastravaha, and Jansisyanont: A review of odontogenic keratocysts and the behavior of recurrences; Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2006;101:5-9
8. Deepak Chaudhary, Manish Bhargava, Shivani Aggraval, Sharanjeet Gill: Keratocystic Odentogenic Tumor- A case report with review of literature; Indian J Stomatol 2012;3(1):66-69
9. Mohammad J. Sharifian and Maryam Khalili: Odontogenic cysts: a retrospective study of 1227 cases in an Iranian population from 1987 to 2007; Journal of Oral Science, Vol. 53, No. 3, 361-367, 2011
10. Mukta B Motwani, Sunil S Mishra, Ruchi M Anand, Shirish S Degwekar, Rahul R Bhowate: Keratocystic Odontogenic Tumor: Case Reports and Review of Literature; Journal of Indian Academy of Oral Medicine and Radiology, April-June 2011;23(2):150-154
11. Walid Ahmed Abdullah: Surgical treatment of keratocystic odontogenic tumour: A review article; The Saudi Dental Journal (2011) 23, 61–65
12. M. Shear: Odontogenic keratocysts: clinical features; Oral Maxillofacial Surg Clin N Am 15 (2003) 335–345
13. Titinchi and Nortje: Keratocystic odontogenic tumor: a recurrence analysis of clinical and radiographic parameters; Oral Surg Oral Med Oral Pathol Oral Radiol 2012;114: 136-142
14. L.J. van Rensburg et al: Correlative MRI and CT imaging of the odontogenic keratocyst: areview of twenty-one cases; Oral Maxillofacial Surg Clin N Am 15 (2003) 363–382
15. H. U. Brauer, C. Diaz, G. Manegold-Brauer: Radiographic assessment of a keratocystic odontogenic tumour using cone-beam computed tomography; Eur Arch Paediatr Dent (2013) 14:173–177
16. Chow Hsun-Tau: Odontogenic keratocyst- A clinical experience in Singapore; Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1998;86:573-7
17. Filip Brzozowski, Hubert Wanyura, Zygmunt Stopa, Katarzyna Kowalska: Odontogenic keratocysts in the material of the Department of Craniomaxillofacial Surgery, Medical University of Warsaw; Czas. Stomatol., 2010, 63, 2, 69-78
18. Nayak, et al.: Odontogenic keratocyst- What is in the name?; Journal of Natural Science, Biology and Medicine July 2013 Vol 4 Issue 2
19. R.C.K. Jordan: Histology and ultrastructural features of the odontogenic keratocyst; Oral Maxillofacial Surg Clin N Am 15 (2003) 325–333
20. Jyothi Mahadesh, Kokila, Laxmidevi B.L: Odontogenic Keratocyst of Maxilla Involving the Sinus – OKC to be a Cyst or a Tumour?; Journal of Dental Sciences & Research Sept 2010: 1:2: Pages 83-90
21. Marker et aL: Treatment of large odontogenic keratocysts by decompression and later cystectomy A long-term follow-up and a histologic study of 23 cases; Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1996;82;122-31
22. Myoung et al.: Odontogenic keratocyst: Review of 256 cases for recurrence and clinicopathologic parameters; Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2001;91:328-33
23. Pogrel And Jordan: Marsupialization as a Definitive Treatment for the Odontogenic Keratocyst; J Oral Maxillofac Surg 62:651-655, 2004
24. Jung, Lee, And Park: Decompression of Large Odontogenic Keratocysts of the Mandible; J Oral Maxillofac Surg 63:267-271, 2005
25. Almeida-Júnior et al: Conservative Approach to the Treatment of Keratocystic Odontogenic Tumor; Journal of Dentistry for Children-77:3, 2010
26. M. ANTHONY POGREL: Treatment of Keratocysts: The Case for Decompression and Marsupialization; J Oral Maxillofac Surg 63:1667-1673, 2005
27. AUGUST ET AL: Dedifferentiation of Odontogenic Keratocyst Epithelium After Cyst Decompression; J Oral Maxillofac Surg 61:678-683, 2003
28. Maurette, Jorge, and Moraes: Conservative Treatment protocol of Odontogenic Keratocyst: A Preliminary Study; J Oral Maxillofac Surg 64:379-383, 2006
29. Yildirim et al.: Conservative Treatment Protocol for Keratocystic Odontogenic Tumour: a Follow-up Study of 3 Cases; J Oral Maxillofac Res 2010 Jul-Sep; vol. 1: No 3, e7.
30. PAUL J.W. STOELINGA: The Treatment of Odontogenic Keratocysts by Excision of the Overlying, Attached Mucosa, Enucleation, and Treatment of the Bony Defect With Carnoy Solution; J Oral Maxillofac Surg 63:1662-1666, 2005.
31. Paul S. Bland, Jacob Shiloah, Molly S. Rosebush: Odontogenic Keratocyst: A Case Report and Review of an Old Lesion with New Classification; Journal of the Tennessee Dental Association 92-2.
32. Aydin Ozkan et al: Management of Keratocystic Odontogenic Tumour With Marsupialisation, Enucleation and Carnoy’s Solution Application: A Case Report; OHDM - Vol. 11 - No. 2 - June, 2012
33. Y Zhao et al: Recurrent keratocystic odontogenic tumours: report of 19 cases; Dentomaxillofacial Radiology (2012) 41, 96-102.
34. Singh and Gupta: Surgical management of odontogenic keratocyst by enucleation; Contemporary Clinical Dentistry; Oct- Dec 2010, Vol 1, Iss 4.
35. Blanas et al: Systematic review of the treatment and prognosis of the odontogenic keratocyst; Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2000;90:553-8
36. Poramate Pitak-Arnnop, Andre Chaine, Nicoleta Oprean, Kittipong Dhanuthai, Jacques-Charles Bertrand, Chloe´ Bertolus: Management of odontogenic keratocysts of the jaws: A ten-year experience with 120consecutive lesions; Journal of Cranio-Maxillo-Facial Surgery 2010: 38; 358e364.
37. SCHMIDT AND POGREL: The Use of Enucleation and Liquid Nitrogen Cryotherapy in the Management of Odontogenic Keratocysts; J Oral Maxillofac Surg 59:720-725, 2001.
38. Zhao, Wei and Wang: Treatment of Odontogenic Keratocysts: A Follow-up of 255 Chinese patients; Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2002;94:151-6.
39. MORGAN, BURTON, AND QIAN: A Retrospective Review of Treatment of the Odontogenic Keratocyst; J Oral Maxillofac Surg 63:635-639, 2005.
40. Madhulaxmi. M and P.U. Abdul Wahab: Carnoy’s solution as a surgical medicament in the Treatment of keratocystic odontogenic tumour; Int J Pharm Bio Sci 2014 Jan; 5(1): (B) 492 – 495.
41. Paul J. W. Stoelinga: Long-term follow-up on keratocysts treated according to a defined protocol; Int. J. Oral Maxillofac. Surg. 2001; 30: 14–25
42. R. Amaral Mendes et al.: Characterization and management of the keratocystic odontogenic tumor in relation to its histopathological and biological features; Oral Oncology 46 (2010) 219–225.
43. GIULIANI ET AL: Conservative Management of a Large Odontogenic Keratocyst: Report of a Case and Review of the Literature; J Oral Maxillofac Surg 64:308-316, 2006.
44. Johnson et al.: Management and recurrence of keratocystic odontogenic tumor: a systematic review; Oral Surg Oral Med Oral Pathol Oral Radiol 2013;116:e271-e276
45. EI-Hajj and Anneroth: 0dontogenic keratocysts-a retrospective clinical and histologic study; Int. J. Oral Maxillofac. Surg. 1996; 25:124-129.
46. G. Enislidis et al.: Conservative treatment of large cystic lesions of the mandible: a prospective study of the effect of decompression; British Journal of Oral and Maxillofacial Surgery (2004) 42, 546—550.
47. Kolokythas et al: Odontogenic Keratocyst: To Decompress or Not to Decompress? A Comparative Study of Decompression and Enucleation Versus Resection/Peripheral Ostectomy; J Oral Maxillofac Surg 65:640-644, 2007.
48. J.A.E.M. Zecha et al:Recurrence rate of keratocystic odontogenic tumor after conservative surgical treatment without adjunctive therapies – A 35-year single institution experience; Oral Oncology 46 (2010) 740–742.
49. Bataineh and Al Qudah: Treatment of mandibular odontogenic keratocysts; Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1998;86:42-7.
50. C Ganesh, Sangeetha GS, Arvindham R: Keratocystic Odontogenic Tumor- Two Case Reports and Review Of Literature; Pakistan Oral & dental Journal Vol 33. No. 3; December 2013.
2. M.A. Pogrel: The history of the odontogenic keratocyst; Oral Maxillofacial Surg Clin N Am 15: 2003: 311–315.
3. T.-J. Li: The Odontogenic Keratocyst: A Cyst, or a Cystic Neoplasm?; J Dent Res 90(2):133-142, 2011
4. Jonathan Madras and Henry Lapointe: Keratocystic Odontogenic Tumour: Reclassification of the Odontogenic Keratocyst from Cyst to Tumour; JCDA March 2008, Vol. 74, No. 2
5. Dolphine Oda, Valiente Rivera, N. Ghanee, E. A. Kenny, K. H. Dawson: Odontogenic Keratocyst: The Northwestern USA Experience; The Journal of Contemporary Dental Practice, Volume 1, No. 2, Winter Issue, 2000
6. P.J.W. Stoelinga: Etiology and pathogenesis of keratocysts; Oral Maxillofacial Surg Clin N Am 15 (2003) 317–324
7. Chirapathomsakul, Sastravaha, and Jansisyanont: A review of odontogenic keratocysts and the behavior of recurrences; Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2006;101:5-9
8. Deepak Chaudhary, Manish Bhargava, Shivani Aggraval, Sharanjeet Gill: Keratocystic Odentogenic Tumor- A case report with review of literature; Indian J Stomatol 2012;3(1):66-69
9. Mohammad J. Sharifian and Maryam Khalili: Odontogenic cysts: a retrospective study of 1227 cases in an Iranian population from 1987 to 2007; Journal of Oral Science, Vol. 53, No. 3, 361-367, 2011
10. Mukta B Motwani, Sunil S Mishra, Ruchi M Anand, Shirish S Degwekar, Rahul R Bhowate: Keratocystic Odontogenic Tumor: Case Reports and Review of Literature; Journal of Indian Academy of Oral Medicine and Radiology, April-June 2011;23(2):150-154
11. Walid Ahmed Abdullah: Surgical treatment of keratocystic odontogenic tumour: A review article; The Saudi Dental Journal (2011) 23, 61–65
12. M. Shear: Odontogenic keratocysts: clinical features; Oral Maxillofacial Surg Clin N Am 15 (2003) 335–345
13. Titinchi and Nortje: Keratocystic odontogenic tumor: a recurrence analysis of clinical and radiographic parameters; Oral Surg Oral Med Oral Pathol Oral Radiol 2012;114: 136-142
14. L.J. van Rensburg et al: Correlative MRI and CT imaging of the odontogenic keratocyst: areview of twenty-one cases; Oral Maxillofacial Surg Clin N Am 15 (2003) 363–382
15. H. U. Brauer, C. Diaz, G. Manegold-Brauer: Radiographic assessment of a keratocystic odontogenic tumour using cone-beam computed tomography; Eur Arch Paediatr Dent (2013) 14:173–177
16. Chow Hsun-Tau: Odontogenic keratocyst- A clinical experience in Singapore; Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1998;86:573-7
17. Filip Brzozowski, Hubert Wanyura, Zygmunt Stopa, Katarzyna Kowalska: Odontogenic keratocysts in the material of the Department of Craniomaxillofacial Surgery, Medical University of Warsaw; Czas. Stomatol., 2010, 63, 2, 69-78
18. Nayak, et al.: Odontogenic keratocyst- What is in the name?; Journal of Natural Science, Biology and Medicine July 2013 Vol 4 Issue 2
19. R.C.K. Jordan: Histology and ultrastructural features of the odontogenic keratocyst; Oral Maxillofacial Surg Clin N Am 15 (2003) 325–333
20. Jyothi Mahadesh, Kokila, Laxmidevi B.L: Odontogenic Keratocyst of Maxilla Involving the Sinus – OKC to be a Cyst or a Tumour?; Journal of Dental Sciences & Research Sept 2010: 1:2: Pages 83-90
21. Marker et aL: Treatment of large odontogenic keratocysts by decompression and later cystectomy A long-term follow-up and a histologic study of 23 cases; Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1996;82;122-31
22. Myoung et al.: Odontogenic keratocyst: Review of 256 cases for recurrence and clinicopathologic parameters; Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2001;91:328-33
23. Pogrel And Jordan: Marsupialization as a Definitive Treatment for the Odontogenic Keratocyst; J Oral Maxillofac Surg 62:651-655, 2004
24. Jung, Lee, And Park: Decompression of Large Odontogenic Keratocysts of the Mandible; J Oral Maxillofac Surg 63:267-271, 2005
25. Almeida-Júnior et al: Conservative Approach to the Treatment of Keratocystic Odontogenic Tumor; Journal of Dentistry for Children-77:3, 2010
26. M. ANTHONY POGREL: Treatment of Keratocysts: The Case for Decompression and Marsupialization; J Oral Maxillofac Surg 63:1667-1673, 2005
27. AUGUST ET AL: Dedifferentiation of Odontogenic Keratocyst Epithelium After Cyst Decompression; J Oral Maxillofac Surg 61:678-683, 2003
28. Maurette, Jorge, and Moraes: Conservative Treatment protocol of Odontogenic Keratocyst: A Preliminary Study; J Oral Maxillofac Surg 64:379-383, 2006
29. Yildirim et al.: Conservative Treatment Protocol for Keratocystic Odontogenic Tumour: a Follow-up Study of 3 Cases; J Oral Maxillofac Res 2010 Jul-Sep; vol. 1: No 3, e7.
30. PAUL J.W. STOELINGA: The Treatment of Odontogenic Keratocysts by Excision of the Overlying, Attached Mucosa, Enucleation, and Treatment of the Bony Defect With Carnoy Solution; J Oral Maxillofac Surg 63:1662-1666, 2005.
31. Paul S. Bland, Jacob Shiloah, Molly S. Rosebush: Odontogenic Keratocyst: A Case Report and Review of an Old Lesion with New Classification; Journal of the Tennessee Dental Association 92-2.
32. Aydin Ozkan et al: Management of Keratocystic Odontogenic Tumour With Marsupialisation, Enucleation and Carnoy’s Solution Application: A Case Report; OHDM - Vol. 11 - No. 2 - June, 2012
33. Y Zhao et al: Recurrent keratocystic odontogenic tumours: report of 19 cases; Dentomaxillofacial Radiology (2012) 41, 96-102.
34. Singh and Gupta: Surgical management of odontogenic keratocyst by enucleation; Contemporary Clinical Dentistry; Oct- Dec 2010, Vol 1, Iss 4.
35. Blanas et al: Systematic review of the treatment and prognosis of the odontogenic keratocyst; Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2000;90:553-8
36. Poramate Pitak-Arnnop, Andre Chaine, Nicoleta Oprean, Kittipong Dhanuthai, Jacques-Charles Bertrand, Chloe´ Bertolus: Management of odontogenic keratocysts of the jaws: A ten-year experience with 120consecutive lesions; Journal of Cranio-Maxillo-Facial Surgery 2010: 38; 358e364.
37. SCHMIDT AND POGREL: The Use of Enucleation and Liquid Nitrogen Cryotherapy in the Management of Odontogenic Keratocysts; J Oral Maxillofac Surg 59:720-725, 2001.
38. Zhao, Wei and Wang: Treatment of Odontogenic Keratocysts: A Follow-up of 255 Chinese patients; Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2002;94:151-6.
39. MORGAN, BURTON, AND QIAN: A Retrospective Review of Treatment of the Odontogenic Keratocyst; J Oral Maxillofac Surg 63:635-639, 2005.
40. Madhulaxmi. M and P.U. Abdul Wahab: Carnoy’s solution as a surgical medicament in the Treatment of keratocystic odontogenic tumour; Int J Pharm Bio Sci 2014 Jan; 5(1): (B) 492 – 495.
41. Paul J. W. Stoelinga: Long-term follow-up on keratocysts treated according to a defined protocol; Int. J. Oral Maxillofac. Surg. 2001; 30: 14–25
42. R. Amaral Mendes et al.: Characterization and management of the keratocystic odontogenic tumor in relation to its histopathological and biological features; Oral Oncology 46 (2010) 219–225.
43. GIULIANI ET AL: Conservative Management of a Large Odontogenic Keratocyst: Report of a Case and Review of the Literature; J Oral Maxillofac Surg 64:308-316, 2006.
44. Johnson et al.: Management and recurrence of keratocystic odontogenic tumor: a systematic review; Oral Surg Oral Med Oral Pathol Oral Radiol 2013;116:e271-e276
45. EI-Hajj and Anneroth: 0dontogenic keratocysts-a retrospective clinical and histologic study; Int. J. Oral Maxillofac. Surg. 1996; 25:124-129.
46. G. Enislidis et al.: Conservative treatment of large cystic lesions of the mandible: a prospective study of the effect of decompression; British Journal of Oral and Maxillofacial Surgery (2004) 42, 546—550.
47. Kolokythas et al: Odontogenic Keratocyst: To Decompress or Not to Decompress? A Comparative Study of Decompression and Enucleation Versus Resection/Peripheral Ostectomy; J Oral Maxillofac Surg 65:640-644, 2007.
48. J.A.E.M. Zecha et al:Recurrence rate of keratocystic odontogenic tumor after conservative surgical treatment without adjunctive therapies – A 35-year single institution experience; Oral Oncology 46 (2010) 740–742.
49. Bataineh and Al Qudah: Treatment of mandibular odontogenic keratocysts; Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1998;86:42-7.
50. C Ganesh, Sangeetha GS, Arvindham R: Keratocystic Odontogenic Tumor- Two Case Reports and Review Of Literature; Pakistan Oral & dental Journal Vol 33. No. 3; December 2013.
Downloads
Published
2018-01-05
How to Cite
Mehta, D. D., Madan, D. S., Shah, D. A., & Mistry, D. E. (2018). Odontogenic Keratocyst- The Controversies in Nomenclature and Treatment Modalities: Odontogenic Keratocyst- The Controversies. National Journal of Integrated Research in Medicine, 5(5), 71–77. Retrieved from http://nicpd.ac.in/ojs-/index.php/njirm/article/view/806
Issue
Section
Original Articles
