Fine Needle Aspiration Cytology: Accurate And Reliable Tool For Primary Diagnosis Of Salivary Gland Lesions.
FNAC: Tool for Diagnosis of Salivary Gland Lesions
Keywords:
FNAC, Salivary gland lesions, HistopathologyAbstract
Background: Management of salivary gland lesions is greatly influenced by preoperative or intraoperative diagnosis of malignancy. Fine needle aspiration cytology (FNAC) is used as a primary diagnostic tool since long. Objective: The objective of study was to evaluate usefulness and diagnostic accuracy of FNAC in primary diagnosis of salivary gland lesions. Methods: Study includes 75 cases suspected of salivary gland lesions evaluated by FNAC from January 2010 to August 2012. Whenever possible follow up histopathology also studied. Results: Out of total of 75 cases of salivary gland lesions 30 cases (40%) were nonneoplastic, 30 cases (40%) were benign and 15 cases (20 %) were malignant. FNAC showed satisfactory sensitivity and specificity with about 91% diagnostic accuracy for benign lesions and for malignant lesions. Conclusions: Study concludes that FNAC has proven to be simple, easy, minimally invasive method with satisfactory accuracy for initial diagnosis of Salivary gland lesions especially benign and malignant neoplasms. It almost accurately type benign tumors like pleomorphic adenoma and showed fair accuracy and reliability. FNAC is vital for management primarily to exclude need of surgery as nonneoplastic lesions are managed conservatively and planning preoperative chemoradiation like in cases of Mucoepidermoid carcinoma arising in odd locations like palate.[Shah M NJIRM 2014; 5(3) :11-17]
References
2. Eneroth C-M, Zajicek J. Aspiration biopsy of salivary gland tumors Im. Morphologic smears and histologic sections from 368 mixed tumors. Acta Cytol 1966;10:440-54.
3. Zajicek J, Eneroth C-M, Jakobsson P. Aspiration biopsy of salivary gland tumors VI. Morphologic investigation on smears and histologic sections of 24 cases of Mucoepidermoid carcinoma. Acta Cytol 1976;20:35-41.
4. Stanley MW. Selected problems in fine needle aspiration of head and neck masses. Mod Pathol 2002; 15: 342–50.
5. Eneroth CM. Salivary gland tumors in the parotid gland, submandibular gland, and the palate region. Cancer 1971; 27: 1415–8.
6. Kamal MM, Dani AA, Kotwal MN, KherdekarMS.Aspiration cytology of salivary gland lesions advantages and pitfalls. Indian J Pathol Microbiol 1994; 37:281–7.
7. J A Young.Diagnostic problems in fine needle aspiration cytopathology of the salivary glands; J Clin Pathol 1994; 47:193-198.
8. Que He CG, Perry CF. Fine-needle aspiration cytology of parotid tumours: is it useful? Aust N Z J Surg. 2001; 71:345–348.
9. Atula T, Gre´nman R, Laippala P, Klemi PJ. Fine-needle aspiration biopsy in the diagnosis of parotid gland lesions.Diagn Cytopathol. 1996; 15:185–190.
10. Zurrida S, Alasio L, Tradati N, Bartoli C, Chiesa F, PilottiS.Fine-needle aspiration of parotid masses. Cancer. 1993; 72:2306–2311.
11. Pitts DB, Hilsinger RL, Karandy E, Ross JC, Caro JE. Fine needle aspiration in the diagnosis of salivary gland disorders in the community hospital setting. Arch Otolaryngol Head Neck Surg. 1992; 118:479–482.
12. Costas A, Castro P, Martin-Granizo R, Monje F, Marron C, Amigo A. Fine needle aspiration biopsy
(FNAB) for lesions of the salivary gland. Br J Oral Maxillofac Surg. 2000; 38:539–542.
13. Wong DSY, Li GKH. The role of fine-needle aspiration cytology in the management of parotid tumors: a critical clinical appraisal. Head Neck. 2000; 22:469–473.
14. Stewart CJR, MacKenzie K, McGarry GW, Mowat A. Fine needle aspiration cytology of salivary gland: a review of 341cases. Diagn Cytopathol. 2000; 22:139–146.
15. Filopoulos E, Angeli S, Daskalopoulou D, Kelessis N, Vassilopoulos P. Pre-operative evaluation of parotid tumours by fine needle biopsy. Eur J Surg Oncol. 1998; 24:180–183.
16. Al-Khafaji BM, Nestok BR, Katz RL. Fine-needle aspiration of 154 parotid masses with histologic correlation. Cancer. 1998; 84:153–159.
17. Shaha AR, Webber C, DiMaio T, Jaffe BM. Needle aspiration biopsy in salivary gland lesions. Am J Surg. 1990 Oct; 160(4):373-6.
18. GC Fernandes, AA Pandit. Diagnosis of salivary gland tumor by FNAC.
19. ShafkatAhrnad; MohainmadLateef: Rouf Ahmad. Clinicopathological Study of Primary Salivary gland tumors in Kashmir JK-Practitioner 2002; 9(4):231-233.
20. Das DK, Petkar MA, Al-Mane NM, Sheikh ZA, Mallik MK, Anim JT. Role of fine needle aspiration cytology in the diagnosis of swellings in the salivary gland regions: a study of 712 cases. Med PrincPract. 2004 Mar-Apr;13(2):95-106.
21. Stewart CJ, Mackenzie K, McGarry GW, Mowat A. Fine-needle aspiration cytology of salivary gland: a review of 341 cases. Diagn Cytopathol. 2000 Mar;22(3):139-46.
22. Erik G. Cohen, MD; Snehal G. Patel, MD; Oscar Lin, MD; Jay O. Boyle, MD; Dennis H. Kraus, MD. Fine-Needle Aspiration Biopsy of Salivary Gland Lesions in a Selected Patient Population; Arch Otolaryngol Head Neck Surg. 2004;130:773-778.
23. Frank W Foote, Edgar L Frazell. Tumors of major salivary gland. Cancer 6: 1065-1133, 1953.
24. Shintani S, Matsuura H, Hasegawa Y. Fine needle aspiration of salivary gland tumors Int J Oral Maxillofac Surg 1997;26: 284-286.
25. Jayaram G, Verma AK, Sood N, Khurana N. Fine needle aspiration cytology of salivary gland lesions. J Oral Pathol Med 1994;23: 256-261.26. Cristallini EG, Ascani S, Farabi R, Liberati F, Maccio T, Peciarolo A, Bolis GB. Fine needle aspiration biopsy of salivary gland, 1985-1995. Acta Cytol. 1997 Sep-Oct;41(5):1421-5.
27. Young JA. Fine needle aspiration cytology of salivary glands. Ear Nose and Throat Journal 1989; 68: 120-129.
28. Bono A, Chiesa F, Sala L, Azzarelli A, Pilotti S, Di Pietro S. Fine-needle aspiration biopsy in parotid masses. Tumori 1983; 69: 417-421
29. O’Dwyer P, Farrar WB, James AG, Finkelmeier W, McCabe DP. Needle aspiration biopsy of major salivary gland tumors. Cancer 1986; 57: 554-557.
30. Jan IS, Chung PF. Analysis of fine needle aspiration cytology of the salivary gland. J Formos Med Assoc. 2008 May;107(5):364-70.
31. CananErsozl, Aysun H. Uguzl, UlkuTuncer, LeventSoylu, Mete Kiroglu Fine needle aspiration cytology of the salivary glands: a twelve year’s experience. Aegean pathology journal 1, 51-56, 2004.
