Bone Morphogenetic Proteins – Potential Role In Periodontal Regeneration
Bone Morphogenetic Proteins
Keywords:
periodontal regeration, bone morphogenetic proteins, periodontitisAbstract
significant goal of periodontology in the recent years has been the regeneration of periodontal tissues to their original form, architecture and function after they have been affected by periodontitis. Periodontal regeneration is a complex wound healing process that involves the structural and functional rebuilding of periodontal tissues that have been lost as a consequence of periodontal diseases. Bone morphogenetic proteins (BMPs) are a group of growth factors and cytokines which are known for their ability to induce the formation of bone and cartilage and have now evoked interest among researchers in this field.
References
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13. Choi SH, Kim CK, Cho KS, Huh JS, Sorensen RG, Wozney JM, Wikesjo¨ UM. Effect ofrecombinant human bone morphogenetic protein-2 ℠absorbable collagen sponge (rhBMP-2 ℠ACS) on healing in 3-wall intrabony defects in dogs. J Periodontol 2002: 73: 63–72.
14. Sorensen RG, Wikesjo¨ UM, Kinoshita A, Wozney JM. Periodontal repair in dogs: evaluation of a bioresorbable calcium phosphate cement (Ceredex) as a carrier for rhBMP-2. J ClinPeriodontol 2004: 31: 796–804
15. Wikesjo¨ UM, Lim WH, Thomson RC, Cook AD, Wozney JM, Hardwick WR. Periodontal repair in dogs: evaluation of a bioabsorbable space-providing macroporous membrane with
recombinant human bone morphogenetic protein-2. J Periodontol 2003: 74: 635–647.
16. Kawakatsu N, Oda S, Kinoshita A, Kikuchi S, Tsuchioka H, Akizuki T, Hayashi C, Kokubo S, Ishikawa I, Izumi Y. Effect of rhBMP 2 with PLGA ℠gelatin sponge type (PGS) carrier on alveolar ridge augmentation in dogs. J Oral Rehabil 2008: 35: 647–655
2. Lavik E, Langer R. Tissue engineering: current state and perspectives. ApplMicrobiolBiotechnol 2004:65:1-8
3. Reddi AH. Regulation of cartilage and bone differentiation by bone morphogenetic protein. CurrOpin Cell Biol 1992;4:850
4. Stone C A. A molecular approach to bone regeneration. British journal of plastic surgery.1997 50: 369-373
5. Pipamonti V, Heliotis M, Van Den Veer, A H Reddi. Bone morphogenetic proteins induce periodontal regeneration in babbon. J Periodontal Res 1994; 29:439-445
6. Ishikawa I, Kinoshita A, Oda S, Roongrunangphol T. Regenerative therapy in periodontal diseases. Histological observations after implantation of rhBMP-2 in the surgically created periodontal defects in adult dogs. Dent Jpn 1994: 31: 141–146.
7. Kinoshita A, Oda S, Takahashi K, Yokota S, Ishikawa I. Periodontal regeneration by application of recombinant human bone morphogenetic protein-2 to horizontal circumferential defects created by experimental periodontitis in beagle dogs. J Periodontol 1997: 68: 103–109.
8. Sigurdsson TJ, Lee MB, Kubota K, Turek TJ, Wozney JM, Wikesjo¨ UM. Periodontal repair in dogs: recombinant human bone morphogenetic protein-2 significantly enhances periodontal regeneration. J Periodontol 1995: 66: 131–138.
9. Blumenthal NM, Koh-Kunst G, Alves ME, Miranda D, Sorensen RG, Wozney JM, Wikesjo¨ UM. Effect of surgical implantation of recombinant human bone morphogenetic protein-2 in a bioabsorbable collagen sponge or calcium phosphate putty carrier in intrabony periodontal defects in the baboon. J Periodontol 2002: 73: 1494– 1506.
10. Sigurdsson TJ, Nygaard L, Tatakis DN, Fu E, Turek TJ, Jin L, Wozney JM, Wikesjo¨ UM. Periodontal repair in dogs: evaluation of rhBMP-2 carriers. Int J Periodontics Restorative Dent 1996: 16: 524–537
11. Miyaji H, Sugaya T, Kato K, Kawamura N, Tsuji H, Kawanami M. Dentin resorption and cementum-like tissue formation by bone morphogenetic protein application. J Periodontal Res 2006: 41: 311–315.
12. Wikesjo¨ UM, Guglielmoni P, Promsudthi A, Cho KS, Trombelli L, Selvig KA, Jin L, Wozney JM. Periodontal repair in dogs: effect of rhBMP-2 concentration on regeneration of alveolar bone and periodontal attachment. J ClinPeriodontol 1999: 26: 392–400.
13. Choi SH, Kim CK, Cho KS, Huh JS, Sorensen RG, Wozney JM, Wikesjo¨ UM. Effect ofrecombinant human bone morphogenetic protein-2 ℠absorbable collagen sponge (rhBMP-2 ℠ACS) on healing in 3-wall intrabony defects in dogs. J Periodontol 2002: 73: 63–72.
14. Sorensen RG, Wikesjo¨ UM, Kinoshita A, Wozney JM. Periodontal repair in dogs: evaluation of a bioresorbable calcium phosphate cement (Ceredex) as a carrier for rhBMP-2. J ClinPeriodontol 2004: 31: 796–804
15. Wikesjo¨ UM, Lim WH, Thomson RC, Cook AD, Wozney JM, Hardwick WR. Periodontal repair in dogs: evaluation of a bioabsorbable space-providing macroporous membrane with
recombinant human bone morphogenetic protein-2. J Periodontol 2003: 74: 635–647.
16. Kawakatsu N, Oda S, Kinoshita A, Kikuchi S, Tsuchioka H, Akizuki T, Hayashi C, Kokubo S, Ishikawa I, Izumi Y. Effect of rhBMP 2 with PLGA ℠gelatin sponge type (PGS) carrier on alveolar ridge augmentation in dogs. J Oral Rehabil 2008: 35: 647–655
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Published
2013-02-28
How to Cite
Kamath, D. D. G., Swati, D., & Nayak, D. S. U. (2013). Bone Morphogenetic Proteins – Potential Role In Periodontal Regeneration: Bone Morphogenetic Proteins. National Journal of Integrated Research in Medicine, 4(1), 121–124. Retrieved from http://nicpd.ac.in/ojs-/index.php/njirm/article/view/454
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Review Article
