Effect Of TXA On Intraoperative Blood Loss In Mandibular Fracture Surgeries A Prospective, Double Blinded Randomized Clinical Trial: Effect Of TXA On Intraoperative Blood Loss In Mandibular Fracture Surgeries

Dr. Zibran Khan; Dr. Darshan Patel; Dr. Bhagavandas Rai; Dr. Mandeepsinh Gohil; Dr. Mayur Mishra; Dr. Parth Parekh

Authors

Dr. Zibran Khan Vydehi Institute Of Dental Science And Research Centre, Dept Of Public Health Dentistry, #82 EPIP AREA, Nellurahalli, Whitefield, Bangalore 560066
Dr. Darshan Patel Vydehi Institute Of Dental Science And Research Centre, Dept Of Public Health Dentistry, #82 EPIP AREA, Nellurahalli, Whitefield, Bangalore 560066
Dr. Bhagavandas Rai Vydehi Institute Of Dental Science And Research Centre, Dept Of Public Health Dentistry, #82 EPIP AREA, Nellurahalli, Whitefield, Bangalore 560066
Dr. Mandeepsinh Gohil Vydehi Institute Of Dental Science And Research Centre, Dept Of Public Health Dentistry, #82 EPIP AREA, Nellurahalli, Whitefield, Bangalore 560066
Dr. Mayur Mishra Vydehi Institute Of Dental Science And Research Centre, Dept Of Public Health Dentistry, #82 EPIP AREA, Nellurahalli, Whitefield, Bangalore 560066
Dr. Parth Parekh Vydehi Institute Of Dental Science And Research Centre, Dept Of Public Health Dentistry, #82 EPIP AREA, Nellurahalli, Whitefield, Bangalore 560066

Keywords:

Mandibular fractures, Tranexamic Acid, Open reduction and internal fixation, Blood loss

Abstract

Background: The aim of this double blind prospective study was to determine whether administering 1 gm Tranexamic Acid (TXA) would the intraoperative blood loss during the Open Reduction and Internal Fixation (ORIF) surgery of mandibular fracture via the intraoral approach operated under local anesthesia (LA). Material And Methods: 20 patients who underwent ORIF surgery of mandibular fractures under LA were randomly allocated to two groups. Study group was administered 1 gm TXA diluted in a 500 ml Ringer Lactate solution one hour before the surgery. Control group did not receive any such IV infusion. All the surgeries were performed by the same surgeon. Result: Mean difference in Intraoperative blood loss between the two groups was found out to be statistically insignificant. Effect of age, gender or site of fracture was also found out to be insignificant. Conclusion: There is not much effect of TXA on intraoperative blood loss during ORIF of a mandibular fracture via the intraoral approach. Even without tranexamic, if area is infiltrated with adrenaline, proper flap reflection and tissue handling technique is used, and vital structures avoided; blood loss will be minimal. [Khan Z Natl J Integr Res Med, 2021; 12(5):36-41]

Effect Of TXA On Intraoperative Blood Loss In Mandibular Fracture Surgeries A Prospective, Double Blinded Randomized Clinical Trial