Uromodulin- Glycated Hemoglobin Ratio Plays The Trump In Diabetic Nephropathy Detection- A Case Control Study

Uromodulin : HbA1c In Diabetic Nephropathy

Abstract

Background: To investigate urine uromodulin as a marker for Diabetic nephropathy (DN) and its relation with glycaemic control. Material & Methods: a cross-sectional comparative study on 180 healthy controls (Group I), 205 patients of Diabetes Mellitus were classified as Group II without microalbuminuria and those with microalbuminuria as Group III.Urineuromodulin, albumin and creatinine was estimated along with routine biochemistry. Results: The FBS, PPBS, HbA1c and serum creatinine were lowest in Group I as compared to groups II and III (p < 0.01, <0.01, <0.01, 0.008 respectively). There was no difference in urine uromodulin levels among the three groups (p= 0.609) but the Uromodulin HbA1c Ratio (UHR) showed a significant difference (p <0.01). UHR showed a statistically significant negative correlation with FBS, PPBS, HbA1c and urine (p= <0.01, <0.01, <0.01 and 0.004 respectively). The Odds of having DN with UHR > 8.6 was 0.49 (95% CI is 0.308- 0.78). Conclusion: The non-occurrence of a diabetic complication that is nephropathy in our study group is favourable to those diabetic patients with a higher UHR (>8.6). Estimation of urine uromodulin will be beneficial along with albuminuria in detecting DN. [Sahu S Natl J Integr Res Med, 2021; 12(1):07-11]