Prevalence Of Uropathogens And Their Antimicrobial Susceptibility Pattern In A Teaching Hospital, Bhavnagar

Prevalence Of Uropathogens And Their Antimicrobial Susceptibility Pattern

Abstract

Background: The objective of the study is to assess the latest antibiotic sensitivity pattern of most commonly isolated organisms in urinary tract infection (UTI). Widespread and irrational use of antibiotics has led to development of highly resistant microorganisms. As the antibiotic sensitivity patterns of the microorganisms are frequently changing, this study was performed to assess the recent antibiotic sensitivity pattern in urinary tract infection among the human population. Methods: Study was conducted from January 2019 to July 2019 at Sir T. Hospital attached with teaching hospital GMC, Bhavnagar. Study population includes all adults (> 18 years olds) both in patients and out patients .2572urine samples were studied. The processing of the samples were done by standard microbiological methods. The antibiotic susceptibility was measured by disk diffusion test. CLSI guidelines were used for the antibiotic susceptibility evaluation. Results: . Out of these 452 (17.57%) samples was found to be positive showing significant bacteria. Out of 452 (culture positive cases) ,276(21.11%)were females and 176(13.91%) were males. Out of 452 positive culture cases more than half cases (54.64 %) reported E.coli, followed by Kleseilla spp.(17.03%),Enterococcus spp.(14.52%), Pseudomonas Spp.(3.92%), proteus spp.(1.76%)Staphylococcus aureus (1.52%),Coagulase negative staphylococcus Spp.(1.32 %) and Candida spp.(5.52%).The study showed marked resistance to quinolones, aminogycosides and greater sensitivity to nitrofurantoin and carbapenum group of antibiotics. Conclusions: The study confirmed, E.coli is still the most common bacteria to cause UTI, irrespective of geographical area. Nitrofurantoin, and carbapenum group of antibiotics showed very high susceptibility to urinary tract infection pathogens, which include most commonly isolated gram-negative bacteria and gram-positive cocci, which were resistant to other various antibiotic groups. Thus, because of orally use, nitrofurantoin seemed to be promising drugs. [Patel S Natl J Integr Res Med, 2019; 10(5):64-67]