Histopathological Study of Prostatic Lesions
Keywords:
Histopathological, Benign Prostatic Hyperplasia (BPH), Prostatic AdenocarcinomaAbstract
Introduction: Prostatic lesions are extremely common in elderly men over the age 50. Prostatic carcinoma is the second most common cause of cancer related deaths and its incidence has been increasing in recent years due to early screening measures. Aim: The purpose of this study is to evaluate histopathological spectrum of prostatic lesions & to correlate them with clinical features and serum PSA level. Methods: A prospective study was conducted in pathology department at Smt. N.H.L. Municipal Medical College on a total 156 prostatic specimens. All specimens were processed by paraffin embedding method and stained by Hematoxylin and Eosin stain. Results: Out of 156 prostatic lesions studied, 112 (71.79%) were benign and 44 (28.21%) were malignant. Peak incidence of both benign and malignant lesions was noted in 7th decade. Most of the patients (82%) were presented with obstructive urinary tract symptoms. Amongst benign lesions, all were found to be of benign prostatic hyperplasia (BPH). Out of 44 cases of prostatic adenocarcinomas, 43 cases were of acinar type; whereas one case was of prostatic ductal adenocarcinoma. Majority of cases with malignant lesions had S.PSA level >10 ng/ml. Gleason score 7 was observed in 45.45% of all malignant lesions. Conclusion: A histopathological examination proves to be gold standard tool for the diagnosis and prognosis of prostatic lesions. S. PSA is an important screening test for early detection of prostatic cancer. [Sabalpara M Natl J Integr Res Med, 2019; 10(5):58-63]
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