The Study of correlation between Malonyldialdehyde Levels and Resting Heart Rate in Depressive Subjects

Study of correlation between Malonyldialdehyde Levels and Resting Heart Rate in Depressive Subjects

Authors

  • Dr. Shashikant Bhausaheb Sabade Assistant Professor
  • Dr Motilal Chandu Tayade Associate Professor
  • Dr Motilal Chandu Tayade Associate Professor
  • Dr Ramachandra G Latti Professor

DOI:

https://doi.org/10.70284/njirm.v10i3.2515

Keywords:

Malonyldialdehyde , resting heart rate , depressive patients

Abstract

Background: There are several molecular changes in the pathogenesis of depression. The aim of our study was to correlate Malonyldialdehyde Levels and Resting Heart Rate in male depressive subjects. Material and Methods: The present observational case control study was conducted in Department of Physiology for a period of three years. A total of 83 depressive cases diagnosed by Psychiatrist were included in the study. Additionally a total of 100 normal individuals without any psychiatric disorder were taken as controls. Non-probability purposive sampling method was adopted for selection of subjects. Correlation between antioxidant malonyldialdehyde levels and heart rate was studied. Results: There was statistical significant correlation observed between malonyldialdehyde with resting heart rate of control group (Unpaired‘t’ test, p value < 0.05) Conclusion: The present study concludes that utility of Malonyldialdehyde Levels and resting heart rate as autonomic function test parameter plays an important role in monitoring management of depressive patients. [Shashikant S Natl J Integr Res Med, 2019; 10(3):34-39]

References

1. Pandya C, Howell K and Pillai A. Antioxidants as potential therapeutics for neuropsychiatric disorders. Prog Neuropsychopharmacol Biol Psychiatry. 2013; October 46: 214–223.
2. Mazereeuw G, Herrmann N, Andreazza AC, Khan MM, Lanctôt KL. Neuropsychiatric Disease and Treatment. 2015;11: 2479–2491.
3. Xu Y, Wang C, Klabnik JJ and O’Donnell1 JM. Novel Therapeutic Targets in Depression and Anxiety: Antioxidants as a Candidate Treatment. Current Neuropharmacology. 2014; 12: 108-119.
4. Buege JA and Aust SD. Microsomal lipid peroxidation Methods in enzymology.1978 (105): 302-310.
5. Rukmini M, D'Souza B and D'Souza V. Superoxide Dismutase and Catalase Activities and their Correlation with Malonyldialdehyde in Schizophrenic Patients. Indian Journal of Clinical Biochemistry 2004; 19 (2): 114-118.
6. Bajpai A, Verma A, Srivasvastava M, Srivasvastava R. Oxidative Stress and Major Depression: Journal of Clinical and Diagnostic Research. 2014 Dec Vol-8(12): CC04-CC07.
7. Liu T, Zhong S, Liao X, Chen J, He T, Lai S, Jia Y. A Meta-Analysis of Oxidative Stress Markers in Depression. journal.pone.0138904 October 7, 2015: 1-17.
8. D'Souza B and D'Souza V. Oxidative Injury and Antioxldant Vitamins E And C in Schizophrenia. Indian Journal of Clinical Biochemistry 2003; 18 (1): 87-90.
9. Mazereeuw G, Herrmann N, Andreazza A, Khan M, Lanctôt K: A Meta-Analysis of lipid Peroxidation Markers in Major Depression. Neuropsychiatric Disease and Treatment 2015; 11: 2479–2491.
10. Atmaca M, Tezcan E, Kuloglu M, Ustundag B, Tunckol H. Antioxidant enzyme and malonyldialdehyde values in social phobia and after citalopram treatment. Eur Arch Psychiatry Clin Neurosci.2004; Aug; 254(4):231-5.
11. Kuloglu M, Atmaca M, Tezcan E, Ustundag B, Bulut S. Antioxidant Enzyme and Malonyldialdehyde Levels in Patients with Panic Disorder. Neuropsychobiology 2002; 46:186–189.
12. Dadheech G, Mishra S, Gautam S and Sharma P; Oxidative Stress, -Tocopherol, Ascorbic Acid and Reduced Glutathione Status in Schizophrenics. Indian Journal of Clinical Biochemistry; 2006; 21 (2): 34-38.
13. Can M, Güven B, Atik L, Konuk N. Lipid Peroxidation and Serum Antioxidant Enzymes Activity in Patients with Bipolar and Major Depressive Disorders: Journal of Mood Disorders 2011; 1:14-18.
14. Carney R, Freedland K, Veith R, Cryer P, Skala J, Lynch T, Jaffe A: Major Depression, Heart Rate and Plasma Norepinephrine in Patients with Coronary Heart Disease Biol Psychiatry. 1999 Feb 15; 45(4):458-63.
15. Alvares G, Quintana D, Hickie I, Guastella A. Autonomic Nervous System Dysfunction in Psychiatric Disorders and the Impact of Psychotropic Medications: A Systematic Review and Meta-Analysis. J Psychiatry Neurosci 2016; 41(2): 89-103.
16. Ehrenthal J, Herrmann-Lingen C, Fey M, Schauenburg H. Altered Cardiovascular Adaptability in Depressed Patients without Heart Disease. World J Biol Psychiatry. 2010; 11:586-93.
17. Jahan C, Begum S, Ferdousi S, Uddin Md. M. Autonomic Dysfunction in Major Depressive Disorder. J Bangladesh Soc Physiol. 2014; June 9(1): 37-41.
18. Wang Y, Zhao X, O'Neil A, Turner A, Liu X and Berk M. Altered Cardiac Autonomic Nervous Function in Depression: BMC Psychiatry 2013; 13:187.

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Published

2019-07-25

How to Cite

Sabade, D. S. B., Tayade, D. M. C., Tayade, D. M. C., & Latti, D. R. G. (2019). The Study of correlation between Malonyldialdehyde Levels and Resting Heart Rate in Depressive Subjects: Study of correlation between Malonyldialdehyde Levels and Resting Heart Rate in Depressive Subjects. National Journal of Integrated Research in Medicine, 10(3), 34–39. https://doi.org/10.70284/njirm.v10i3.2515

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Original Articles