Development and Clinical Evaluation Of Transmucosal Mucoadhesive Patch Of Lornoxicam For The Odontogenic Pain Management -A Preliminary Study

Clinical evaluation of transmucosal mucoadhesive lornoxicam patch in dental pain reduction: A preliminary study:Development and Clinical Evaluation Of Transmucosal Mucoadhesive Patch Of Lornoxicam For The Odontogenic Pain Management -A Preliminary Study

Abstract

Background: Pain is the most common complaint of the patient that brings him to the dentist, often occurring in conjunction with inflammation and which considerably reduce patient quality of life. Nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly prescribed for the dental pain management. The GI complications associated with NSAIDs can be effectively overcome if they are delivered by transmucosal route in the form of buccal patch. Aim: To evaluate the efficacy of mucoadhesive lornoxicam patches in odontogenic pain management. Materials and Method: The study was conducted in 60 adult patients of either sex, diagnosed with odontogenic pain and were attending the outpatient department. Informed consent was obtained from all the patients. A 1×1 cm mucoadhesive patch containing 4 mg of lornoxicam was applied on the attached gingival region of the tooth with pain. Pain was recorded using a ten point visual analogue scale (VAS) score before and every 5 min till 30 min after the application of the patch. Statistical analysis was done using repeated measure ANOVA with p<0.05. Results: The results of the study revealed a significant drop in the pain scores from baseline to the score recorded after 30min (p<0.05). Conclusion: The results of the present study conclusively suggested the suitability, safety and efficacy of the transmucosal delivery of lornoxicam in the form of mucoadhesive patch for the management of odontogenic pain. [Thriveni R Natl J Integr Res Med, 2019; 10(4):26-30]