Clinico-pathological spectrum of breast cancer patients with reference to Nottingham Prognostic index
Clinico-pathological spectrum of breast cancer patients with reference to Nottingham Prognostic index
Keywords:
Breast carcinoma, clinical features, Grade, NPI, pathological featuresAbstract
Background & objectives: Breast cancer is one the major causes of cancer related deaths in women worldwide. It has variable clinical, pathological and prognostic determinants. Nottingham modification of Bloom Richardson grading and Nottingham Prognostic Index have significant impact on the prognostication of breast carcinoma. The present study is conducted to evaluate the clinico-pathological features and to study their association with Modified Bloom Richardson grade and Nottingham Prognostic Index in patients attending a Tertiary care hospital in North Karnataka. Methods: Operated specimens of 136 cases of breast carcinoma were evaluated for clinico-pathological features. The association between these variables and Bloom Richardson grades and Nottingham Prognostic Index were calculated using Chi-square test. P value of </=0.05 was considered significant. Results: Size, lymphovascular invasion, necrosis, lymphocytic infiltration showed significant association with higher grades. Menopausal status, Hindu religion, Fixation to chest, lymphovasular invasion, necrosis, lymphnode positivity showed significant association with poor indices of NPI scores. conclusion: Evaluation of the clinicopathological features of breast carcinoma along with modified Bloom Richardson grade and Nottingham prognostic Index may help in planning and making therapeutic decisions in patients with breast carcinoma. [Hungund B Natl J Integr Res Med, 2019; 10(3):20-28]
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