Aceclofenac and Analgesic Nephropathy :  A Transcendent Adverse Effect of Concern: Aceclofenac and Analgesic Nephropathy

Amee Pandya; Sapna Gupta; Jaldipsinh Gohil; Supriya Malhotra; Pankaj Patel

Authors

Amee Pandya First Year Resident, Department of Pharmacology, Smt.NHL Municipal Medical College, Ahmedabad, Gujarat, India-380006
Sapna Gupta Assistant Professor, Department of Emergency Medicine, Smt.NHL Municipal Medical College, Ahmedabad, Gujarat, India-380006
Jaldipsinh Gohil Second Year Resident, Department of Emergency Medicine, Smt.NHL Municipal Medical College, Ahmedabad, Gujarat, India-380006
Supriya Malhotra Professor and Head, Department of Pharmacology, Smt.NHL Municipal Medical College, Ahmedabad, Gujarat, India-380006
Pankaj Patel Dean, Smt.NHL Municipal Medical College, Ahmedabad, Gujarat, India-380006

Keywords:

Aceclofenac, Acute renal failure, Analgesic nephropathy, Pharmacovigilance

Abstract

To eliminate the preventable deaths due to Acute Kidney Failure(ARF), especially due to chronic usage of over the counter non-steroidal anti-inflammatory drugs (NSAID) medications should be a pre-defined healthcare goal. Ever after the discovery of selective cyclooxygenase-2 (COX-2) inhibitors, nephrotoxicity still remains a concern. Here we are highlighting a case of Aceclofenac induced Acute on chronic renal disease exemplifying unregulated use of NSAIDs is an under recognized and potentially dangerous problem and that constant pharmacovigilance is the key to detect such events. This case was notified and uploaded to Vigiflow with Iâ€™d 2018-58102. Even after the availability of diversity of NSAIDs, a renal safe NSAID is yet to be discovered. [Pandya A Natl J Integr Res Med, 2019; 10(1):51-53]

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Aceclofenac and Analgesic Nephropathy : A Transcendent Adverse Effect of Concern