Pulse Wave Analysis In Gujarati Type 1 Diabetics: A Case Control Study

Pulse Wave Analysis In Gujarati Type 1 Diabetics

Authors

  • Jayesh Solanki Assistant Professor, Department Of Physiology, GMC, Bhavnagar
  • Hirava Munshi Assistant Professor, Department of General Medicine. Government Medical College, Bhavnagar
  • Chinmay shah

Keywords:

Arterial stiffness; blood pressure; haemodynamic; pulse wave analysis, type 1 diabetes

Abstract

Introduction: Type 1 Diabetes is an early onset disease that imposes significant cardiovascular risk. Arterial stiffness and central haemodynamics are immediate and discrete parameters but studied scarcely. Pulse wave analysis (PWA) allows non-invasive measurement of them which we undertook in diabetics. Methodology: We performed a case control study on 36 treated type 1 diabetics and 36 non-diabetic, normotensive, matched controls. Oscillometric pulse wave analysis (PWA) was performed by Mobil-o-Graph (IEM, Germany). Parameters were compared between case and controls. Multiple linear regressions were accomplished to find significant predictors. P < 0.05 was taken as statistical significance. Results: - Cases showed significantly raised brachial haemodynamics (blood pressure, heart rate, rate pressure product); arterial stiffness (augmentation pressure, augmentation index, pulse wave velocity, total arterial stiffness, pulse pressure amplification) and central haemodynamics (central blood pressure, cardiac output, stroke work) than controls, with statistical significance for not all. Most outcome parameters were predicted by age, HR, BP to lesser extents. Genders, presence of hypertension, glycemic control, blood pressure control, physical activity were not significantly affecting study outcomes in case group. Conclusion: Gujarati type 1 diabetics had beyond brachial blood pressure, adverse profile of discrete cardiovascular parameters; independent of conventional confounders; suggesting vascular progeria. This baseline work hints further study of these PWA parameters. [Solanki J Natl J Integr Res Med, 2018; 9(6):-59-65]

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Published

2018-12-31

How to Cite

Solanki, J., Munshi, H., & shah, C. (2018). Pulse Wave Analysis In Gujarati Type 1 Diabetics: A Case Control Study: Pulse Wave Analysis In Gujarati Type 1 Diabetics. National Journal of Integrated Research in Medicine, 9(6), 59–65. Retrieved from http://nicpd.ac.in/ojs-/index.php/njirm/article/view/2463

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