Hepatitis B Immunization Status of Health Care Personnel
Hepatitis B Immunization Status of Health Care Personnel
DOI:
https://doi.org/10.70284/njirm.v9i4.2379Keywords:
Health Care Personnel, HBV, anti-HBs antibody titreAbstract
Background & objectives: Post-vaccination anti-HBsAg antibody titer measurements among Health Care Personnel (HCP) are not being done routinely at present. The present study was carried out to assess the post vaccination immunization status of HCP and to find an association between demographic & host factors and level of immunity. Methods: Cross-sectional prospective study was conducted at Shree Krishna Hospital, Karamsad. Information on Hepatitis B Virus (HBV) vaccination status and demographic details of HCP were collected using a structured proforma through verbal interviews and hospital information system. Anti-HBs antibody titre was determined by Enzyme Linked Immunofluorescent Assay (ELFA). Results : They were analysed using Pearson Chi2 test and Fisher’s exact test. Results: Among 505 participants, 96.4% developed protective antibody titres (≥ 10 mIU/ml) after primary vaccination. Following revaccination of participants with insufficient titres, 100% developed protective antibodies. There were no non-responders in the study. There was a significant association between anti-HBs antibody titres and duration after last dose of vaccine (p = 0.01) whereas no correlation was found between antibody titres and gender, age group, BMI & category of HCP. conclusions: HBV vaccination showed an excellent response following primary vaccination. For HCP with insufficient titres after primary vaccination, re-vaccination and re-testing is recommended.[Khristi P,Natl J Integr Res Med, 2018; 9(4):37-42]
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Antibody to hepatitis B surface antigen in
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different vaccines in Palestinian children
vaccinated in early childhood. Human Vaccines &
Immunotherapeutics July 2015;11:1717-1724.
Guidelines for Evaluating Health Care Personnel
for Hepatitis B Virus Protection and for
Administering Post-exposure Management
Recommendations. MMWR 2013;62:1-24.
2. Zeeshan M, Jabeen K, Ali AN, Ali AW, Farooqui SZ,
Mehraj V, et al. Evaluation of immune response to
hepatitis B vaccine in health care workers at a
tertiary care hospital in Pakistan: An observational
prospective study. BioMed Central Infectious
Diseases 2007;7:120.
3. Williams JL, Christensen CJ, McMahon BJ, Bulkow
LR, Cagle HH, Mayers JS, et al. Evaluation of the
response to a booster dose of hepatitis B vaccine
in previously immunized health care workers.
Vaccine 2001;19:4081-4085.
4. Chaudhari CN, Bhagat MR, Shah T, Misra RN.
Antibody to hepatitis B surface antigen in
vaccinated health care workers. Medical Journal
of Armed Forces India 2008;64:329-332.
5. Singhal V, Bora D, Singh S. Hepatitis B in health
care workers: Indian scenario. Journal of
Laboratory Physicians 2009;1:41-48.
6. Chouhan S. Hepatitis B prophylaxis practice
among medical students: An overview. Hepatitis B
Annual 2008;5:102-116.
7. West D, Calandra G. Vaccine induced immunologic
memory for hepatitis B surface antigen:
Implications for policy on booster vaccination.
Vaccine 1996;14:1019-1027.
8. Barash C, Conn MI, DiMarino AJ Jr, Marzano J,
Allen ML. Serology of Hepatitis B Immunity in
Vaccinated Health Care Workers. Archives of
Internal Medicine 1999;159:1481-1483.
9. Rao TV, Suseela IJ, Sathiavathy KA. Estimation of
antibodies to HBsAg in vaccinated health care
workers. Indian J Med Microbiol 2008;26:93-94.
10. John M. Hepatitis B immunization and post
immunization serology. Journal of Canadian
Dental Association 2000;66:551-552.
11. Batra V, Goswami A, Dadhich S, Kothari D,
Bhargava N. Hepatitis B immunization in health
care workers. Annals of Gastroenterology
2015;28:276-280.
12. Ganczak M. A Cross-Sectional Study on Anti
Hepatitis B Immune Status in Vaccinated
Healthcare Workers in the West Pomeranian
Region of Poland. Hepatitis Monthly 2012;12:185-
189.
13. Lin C, Xie S, Liu J, Zhao Z, Chong Y, Gao Z. Effect of
Revaccination Using Differenr Schemes among
Adults with Low or Undetectable Anti-HBs Titers
after Hepatitis B Virus Vaccination. Clinical and
Vaccine Immunology Oct 2010;17:1548-1551.
14. Norouzirad R, Shakurnia A. H., Assarehzadegan M,
Serajian A, Khabazkhoob M. Serum Levels of Anti-
Hepatitis B Surface Antibody Among Vaccinated
Population Aged 1 to 18 Years in Ahvaz City
Southwest of Iran. Hepatitis Monthly
2014;14:e13625.
15. Elmaghlob, R, Didamony G. El, Elbahrawy A,
Abdallah A. M., Hamida M. H., Elwassief A, et al.
Immune Response after Hepatitis B Vaccination
among Egyptian Medical Students in Nile Delta.
World Journal of Vaccine 2015;5:140-146.
16. Han Ke, Shao X, Zheng H, Wu C, ZhuJ, Zheng X, et
al. Revaccination of non and low responders after
a standard three dose hepatitis B vaccine
schedule. Human Vaccines & Immunotherapeutics
December 2012;8:1845-1849.
17. Jain AK, Mittal SK, Ramji S, Chakravarti A. Hepatitis
B vaccine in the EPI schedule. Indian Journal of
Pediatrics 2005;72:661-664.
18. Zhang Li, Liu J, Lu J, Yan B, Song L, Li Li., et al.
Antibody response to revaccination among adult
non-responders to primary Hepatitis B vaccination
in China. Human Vaccines & immunotherapeutics
2015;11:2716-2722.
19. Das K., Gupta R. K., Kumar V., Kar P.
Immunogenicity and reactogenicity of a
recombinant Hepatitis B vaccine in subjects over
40 years of age and response to a booster among
non responders. World Journal of
Gastroenterology 2003;9:1132-1134.
20. Tripathy S, Sati HC, Puspa, Saha S, Shankar R,
Singh VK. Study of Immune Response after
Hepatitis B Vaccination in Medical Students and
Health Care Workers. Indian Journal of Preventive
and Social Medicine 2011;42:315-321.
21. Momeni N, Akhoundi M. S. A., Alavian S. M.,
Shamshiri A. R., Norouzi M, Mahboobi N. HBV
Vaccination Status and Response to Hepatitis B
Vaccine Among Iranian Dentists, Correlation With
Risk Factors and Preventive Measures. Hepatitis
Monthly 2015;15:e20014.
22. Alavian SM, Mahboobi N. Anti-HBs antibody status
and some of its associated factors in dental health
care workersin Tehran University of Medical
Sciences: Anti-HBs Ab and associated factors in
dental society. Hepatitis Monthly 2011;11:99-102.
23. Alavian SM, Izadi M, Zare AA, Lankarani MM,
Assari S, Vardi MM. Survey of the level of anti-HBs
antibody titre in vaccinated Iranian general
dentists. Special Care in Dentistry 2008;28:265-
270.
24. Kollathodi N, Moorkoth AP, George K, Narayanan
MP, Balakrishnan SM, Lalithabai SD.Hepatitis B
vaccination – immune response and persistence of
protection in susceptible population. Journal of
The Academy of Clinical Microbiologists
2017;19:42-46.
25. Chaudhari CN, Bhagat MR, Shah T, Misra RN.
Antibody to hepatitis B surface antigen in
vaccinated health care workers. Medical Journal
of Armed Forces India 2008;64:329-332.
26. Roome AJ, Walsh SJ, Cartter ML, Hadler JL.
Hepatitis B vaccine responsiveness in Connecticut
public safety personnel. The Journal of theAmerican Medical Association 1993;270:2931-
2934.
27. Gilca V, Serres G, Boulianne N, Murphy D, Wals P,
Ouakki M, et al. Antibody persistence and the
effect of a booster dose given 5, 10 or 15 years
after vaccinating preadolescents with a
recombinant hepatitis B vaccine. Vaccine
2013;31:448-451.
28. Wang CW, Wang LC, Chang MH, Ni YH, Chen HL,
Hsu HY, et al. Long term follow-up of Hepatitis B
surface antibody levels in subjects receiving
universal Hepatitis B vaccination in infancy in an
area of hyperendemicity: Correlation between
radioimmunoassay and enzyme immunoassay.
Clinical Diagnostic Laboratory Immunology
2005;12:1442-1447.
29. Willacy H. Hepatitis B vaccination and prevention
(Doctors/patients) U K. 16 Oct 2009,
www.patient.co.uk (Last checked on 05 June,
2015) Available from:
https://patient.info/doctor/hepatitis-bvaccination-
and-prevention.
30. Qawasmi M, Samuh M, Glebe D, Gerlich W. H.,
Azzeh M. Age dependent decrease of anti-HBs
titers and effect of booster doses using two
different vaccines in Palestinian children
vaccinated in early childhood. Human Vaccines &
Immunotherapeutics July 2015;11:1717-1724.
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Published
2018-08-31
How to Cite
Purvi, K., Patel, R., & Modi, C. (2018). Hepatitis B Immunization Status of Health Care Personnel: Hepatitis B Immunization Status of Health Care Personnel. National Journal of Integrated Research in Medicine, 9(4), 37–43. https://doi.org/10.70284/njirm.v9i4.2379
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