Chromosomal Analysis In Couples With Recurrent Spontaneous Abortion: A Case Control Study
Chromosomal Analysis In Couples With Recurrent Spontaneous Abortion: A Case Control Study
DOI:
https://doi.org/10.70284/njirm.v9i4.2377Abstract
Background: Normal expected outcome of a couple is birth of a healthy child after completion of the period of pregnancy. About 50% of pregnancies end in fetal loss as abortion. Lower implantation and higher spontaneous abortion rate are closely associated with the chromosomal abnormalities of the parents. It has been recommended that the standard investigation of such cases should include karyotyping of both the parents for chromosomal aberrations. The aim of the study was to find out whether any specific chromosomal abnormalities exist in couples with recurrent spontaneous abortion. Method: 75 couples with history of recurrent spontaneous abortion as well as 75 fertile couples as control were investigated for chromosomal aberrations. Statistical analysis (Chi square test) was done to find out the association of recurrent spontaneous abortion with chromosomal abnormalities of the parents. Result: Out of 75 couples (150 subjects) with recurrent spontaneous abortion, 10 subjects(6.7%) were found to be having abnormal karyotypes. The statistical analysis (p<0.05) signifies that chromosomal abnormalities of the parents are associated with recurrent spontaneous abortion. Conclusion: Recurrent spontaneous abortion continues to be a challenging reproductive problem for the clinician. Therefore, identifying a cytogenetic cause may be of great significance for the management of such cases. [Malamoni D, Natl J Integr Res Med, 2018; 9(4):25-31]
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syndrome: a study of 216 infertile Egyptian
patients. J Androl.2012;33(3):441-448
26. Makino T, Tabuchi T, Nakada K, Iwasaki K et al.
Chromosomal analysis in Japanese couples with
repeated spontaneous abortion. Int J
Fertil.1990;35:266-270
27. Sheth FJ, Liehr T, Kumari P, Akinde R et al.
Chromosomal abnormalities in couples with
repeated fetal loss: An Indian retrospective study.
Indian J Hum Genet.2013;19:415-422
28. Alaraji SMH. Chromosomal abnormalities
associated with recurrent spontaneous abortions
in Iraqi women. Med J Babylon.2014;7:2
29. De P, Chakravarty S, Chakravarty A. Novel balance
chromosomal translocations in females with
recurrent spontaneous abortions: Two case
studies. J Hum Reprod Sci.2015;8:114-117
30. Kochhar PK and Ghosh P. Reproductive outcome
of couples with recurrent miscarriage and
balanced chromosomal abnormalities. J Obstet
Gynaecol Res.2013;39:113-120
31. Celep F, Karaguzel A, Ozeren M, Bozkaya H. The
frequency of chromosomal abnormalities in
patients with reproductive failure. Eur J Obstet
Gynecol Reprod Biol.2006;127(1):106-109
32. Fryus JP, Van Buggenhout G. Structural
chromosome rearrangements in couples with
recurrent fetal wastage. Eur J Obstet Gynecol
Reprod Biol.1998;8(2):171-6
33. Panasink B, Danik J, Lurie IW, Stasiemiz-Jaracka B,
Leuniewicz R, Sawicka A et al. Reciprocal
chromosome translocations involving short arm of
chromosome 9 as a risk factor of unfavourable
pregnancy outcomes after meiotic malsegregation
2:2.Adv Med Sci.2009;54(2):203-10
34. De la Fuente-Cortes BE, Cerda-Flores RM, Davila-
Rodrigauez MI, Garcia-Vielma C, De la Rosa
Alvardo RM, Cortes-Gutierrez EL. Chromosomal
abnormalities and polymorphic variants in couples
with repeated miscarriage in Mexico.
Reproductive Biomedicine
online;www.rbmonline.com/Article/3534 on web
29 Jan 2009.vol18 (4):543-548.
adolescent with vaginal bleeding: Etiology,
diagnosis and management. Paediatric emergency
care. 2006;22(10):76-77
2. Meka A. and Reddy M. Recurrent Spontaneous
Abortions: An Overview of Genetic and Non-
Genetic Backgrounds. Int J Hum Genet. 2006;
6(2):109-117
3. Edmonds DK. Recurrent Miscarriage. Dew Hurst’s
Text Book OfObstetrics and Gynaecology. 7th ed.
Blackwell Publishing. Oxford,
Massachusettes,2007 :100-105
4. ImpeyL. Disorders of early pregnancy. Obstetrics
and Gynaecology. 2nd ed. John Wiley & Sons Ltd.
Oxford,2004:94-95
5. Schoenwo lf GC, Bleyl SB, Brauer PR, Francis-West
PH. Gametogenesis, Fertilization and the First
week. Larsen’s Human Embryology.
5thed.ChurcillLivingstone. Philadelphia, 2015:14-42
6. Hassold T, Jacobs PA, Pettay D. Cytogenetic
studies of couples with repeated spontaneous
abortions of known karyotype. Genet
Epidemiol.1988; 5(2):65-74
7. Exalto N. Recurrent miscarriage. IntCongr
Ser.2005;1279: 247-50
8. Yuce H, Tekederell L, Elyas H. Cytogenetic results
of recurrent spontaneous abortions in Turkey.
Medical Science Monitor.2007;13(6):286-289
9. Khedekar DN, Kesari GV, Kotwaliwale SS,
Hattangdi SS. Cytogenetic study of leucocyte
culture in multiple pregnancy loss in Mumbai.
International J of Genetics.2012;4(2):80-84
10. PurandareH, Chakravarty A. Human Cytogenetic
techniques and clinical applications. Bhilani
Publishing House, Mumbai.2000;182-203
11. Cheng L, Zhang DY. Molecular Genetic Pathology
in Principles of Clinical Cytogenetics. Human Press,
Indiapolis, New York,2008;41-61
12. Carp H, Guetta E, Dore H, Soriano D, Barkai G,
Schiff E. Embryonic Karyotype in recurrent
miscarriage with parental aberrations. Fertil
Steril.2006;85:446-50
13. 13. Lee RM, Silver RM. Recurrent pregnancy loss;
summary and clinical recommendations. Semin
Reprod Med. 2000;18:433-40
14. 14. McGowan-Jordan J, Simons A, Schmid, editors.
ISCN 2016: An International System of Human
Cytogenomic Nomenclature. Basil: S karger
AG.2016
15. 15.Cortes B, Cerda R, Davila M, Garcia C, De La
Rosa R, Cortes E. Chromosomal abnormalities and
polymorphic variants in couples with repeated
miscarriages in Mexico. Reprod Biomed
online.2009;18(4):543-548
16. 16.El-Dahtory FA. Chromosomal abnormalities as
a cause of recurrent abortions in Egypt. Ind J Hum
Genet.2011;17(2):82-84
17. Al-Hassanee A, Abdulameer S, Kashmoola M.
Chromosomal abnormality in couple with
repeated abortion. Tikrit Medical
Journal.2012;8(1):48-53
18. Gaboon N, Mohamed A, Elsayed S, Zaki O, Elsayed
M. Structural chromosomal abnormalities incouples with recurrent abortion in Egypt. Turk J
Med Sci.2015;45:208-213
19. Azim M, Khan AH, Khilji ZL, Pal JA, Khurshid M.
Chromosomal abnormalities as a cause of
recurrent abortions: a hospital experience. J Pak
Med Assoc.2003; 53:117-119.
20. Dubey S, Chowdhury M, Prahlad B, Kumar V,
Mathur R, Hamilton S, Kabra M, Menon PSN,
Verma IC. Cytogenetic causes for recurrent
spontaneous abortions-An experience of 742
couples(1484 cases). Indian J Hum
Genet.2005;11:94-98.
21. Dutta U, Rajitha P, Pidugu V, Dalal A. Cytogenetic
abnormalities in 1162 couples with recurrent
miscarriages in southern region of India: Report
and Review. J Assist Reprod Genet.2010;28:145-
149
22. Meshkat Z, Khadem Ghaebi N, Khajedaluee M,
Aghili Z, Rostami S. Prevalance of chromosomal
aberrations in couples with recurrent miscarriages
in the city of Mashhad, Iran: A cross sectional
study. Arch Med Lab Sci.2016;2(1):19-23
23. Kiss A, Rosa RFM, Dibi RP, Zen PRG, Pfeil JN,
Graziadio C, etal. Chromosomal abnormalities in
couples with history of recurrent abortion. Rev
Bras Ginecol Obstet.2009;31(2):68-74.
24. Pal S, Ma S, Norhasimah M, Suhaida M, Siti
Mariam I, Ankathil R, Zilfalil B. Chromosomal
abnormalities and reproductive outcome in
Malaysian couples with miscarriage. Singapore
Med J.2009;50(10):1008-1012
25. Abdel-Razia MM, Abdel-Hamid IA, Elsobky E, ELDahtory
F. Further evidence of the clinical,
hormonal and genetic heterogenicity of Klinefelter
syndrome: a study of 216 infertile Egyptian
patients. J Androl.2012;33(3):441-448
26. Makino T, Tabuchi T, Nakada K, Iwasaki K et al.
Chromosomal analysis in Japanese couples with
repeated spontaneous abortion. Int J
Fertil.1990;35:266-270
27. Sheth FJ, Liehr T, Kumari P, Akinde R et al.
Chromosomal abnormalities in couples with
repeated fetal loss: An Indian retrospective study.
Indian J Hum Genet.2013;19:415-422
28. Alaraji SMH. Chromosomal abnormalities
associated with recurrent spontaneous abortions
in Iraqi women. Med J Babylon.2014;7:2
29. De P, Chakravarty S, Chakravarty A. Novel balance
chromosomal translocations in females with
recurrent spontaneous abortions: Two case
studies. J Hum Reprod Sci.2015;8:114-117
30. Kochhar PK and Ghosh P. Reproductive outcome
of couples with recurrent miscarriage and
balanced chromosomal abnormalities. J Obstet
Gynaecol Res.2013;39:113-120
31. Celep F, Karaguzel A, Ozeren M, Bozkaya H. The
frequency of chromosomal abnormalities in
patients with reproductive failure. Eur J Obstet
Gynecol Reprod Biol.2006;127(1):106-109
32. Fryus JP, Van Buggenhout G. Structural
chromosome rearrangements in couples with
recurrent fetal wastage. Eur J Obstet Gynecol
Reprod Biol.1998;8(2):171-6
33. Panasink B, Danik J, Lurie IW, Stasiemiz-Jaracka B,
Leuniewicz R, Sawicka A et al. Reciprocal
chromosome translocations involving short arm of
chromosome 9 as a risk factor of unfavourable
pregnancy outcomes after meiotic malsegregation
2:2.Adv Med Sci.2009;54(2):203-10
34. De la Fuente-Cortes BE, Cerda-Flores RM, Davila-
Rodrigauez MI, Garcia-Vielma C, De la Rosa
Alvardo RM, Cortes-Gutierrez EL. Chromosomal
abnormalities and polymorphic variants in couples
with repeated miscarriage in Mexico.
Reproductive Biomedicine
online;www.rbmonline.com/Article/3534 on web
29 Jan 2009.vol18 (4):543-548.
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Published
2018-08-31
How to Cite
Dutta, M., Mahanta, J., Chandra Das, G., & Kumar Rai, A. (2018). Chromosomal Analysis In Couples With Recurrent Spontaneous Abortion: A Case Control Study: Chromosomal Analysis In Couples With Recurrent Spontaneous Abortion: A Case Control Study. National Journal of Integrated Research in Medicine, 9(4), 25–31. https://doi.org/10.70284/njirm.v9i4.2377
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