Chromosomal Analysis In Couples With Recurrent Spontaneous Abortion: A Case Control Study

Chromosomal Analysis In Couples With Recurrent Spontaneous Abortion: A Case Control Study

Authors

  • Malamoni Dutta Associate Professor, Department of Anatomy, Assam Medical College, Dibrugarh,
  • Jagadish Mahanta Former Director R.M.RC(Dibrugarh) Cum Distinguished Scientist Chair,ICMR, New Delhi
  • Gokul Chandra Das Rtd. Professor And Ex Head Of The Department Of Obstetrics And Gynaecology, Gauhati Medical College, Ghy-32,
  • Avdesh Kumar Rai Assistant Research Officer, DBT Centre For Molecular Biology And Cancer Research, B.B.C.I, Guwahati, India

Abstract

Background: Normal expected outcome of a couple is birth of a healthy child after completion of the period of pregnancy. About 50% of pregnancies end in fetal loss as abortion. Lower implantation and higher spontaneous abortion rate are closely associated with the chromosomal abnormalities of the parents. It has been recommended that the standard investigation of such cases should include karyotyping of both the parents for chromosomal aberrations. The aim of the study was to find out whether any specific chromosomal abnormalities exist in couples with recurrent spontaneous abortion. Method: 75 couples with history of recurrent spontaneous abortion as well as 75 fertile couples as control were investigated for chromosomal aberrations. Statistical analysis (Chi square test) was done to find out the association of recurrent spontaneous abortion with chromosomal abnormalities of the parents. Result: Out of 75 couples (150 subjects) with recurrent spontaneous abortion, 10 subjects(6.7%) were found to be having abnormal karyotypes. The statistical analysis (p<0.05) signifies that chromosomal abnormalities of the parents are associated with recurrent spontaneous abortion. Conclusion: Recurrent spontaneous abortion continues to be a challenging reproductive problem for the clinician. Therefore, identifying a cytogenetic cause may be of great significance for the management of such cases. [Malamoni D, Natl J Integr Res Med, 2018; 9(4):25-31]

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Published

2018-08-31

How to Cite

Dutta, M., Mahanta, J., Chandra Das, G., & Kumar Rai, A. (2018). Chromosomal Analysis In Couples With Recurrent Spontaneous Abortion: A Case Control Study: Chromosomal Analysis In Couples With Recurrent Spontaneous Abortion: A Case Control Study. National Journal of Integrated Research in Medicine, 9(4), 25–31. Retrieved from http://nicpd.ac.in/ojs-/index.php/njirm/article/view/2377

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