Study The Risk Of Chronic Obstructive Pulmonary Diseases Among Successfully Treated Old Pulmonary Tubercular Cases By Measuring Lung Function Indices - A Hospital Based Case Control Multi Group Study
Risk Of Chronic Obstructive Pulmonary Diseases Among Successfully Treated Old Pulmonary Tubercular cases
Keywords:
Tuberculosis, Lungs, COPD, Tobacco Smoke, Biomass Fuel smoke, Pulmonary function test.Abstract
Background: Pulmonary tuberculosis consider as an independent risk factor for COPD by few recent researcher apart from tobacco smoke and biomass fuel though not much explored hitherto, therefore study conducted to find out possible association in between two epidemics of era. Methods: A hospital based multi group case control study was conducted in tertiary care centre of teaching institute by including 200 subjects comprises in four groups ,Group 1: 50 successfully treated non-smoker, non-biomass fuel smoke exposed, successfully treated patients of Pulmonary Koch’s, currently sputum negative. ; Group 2: 50 individuals with history of exposure to biomass fuel smoke. ; Group 3: 50 smokers, currently asymptomatic; Group 4: 50 normal (healthy) individuals, non smokers, non-biomass fuel smoke exposed and not having any history of tuberculosis.PFT was done in all included subjects. Data compiled and analyzed by using Standard statistical software spss23.p value <0.05 consider as significant. Results: Only 8(16%) subjects among old treated pulmonary tuberculosis having COPD (odd ratio= 2.19) contrary to this 14(28%) and12 (24%) subjects among smokers and biomass smoke exposed having COPD (odd ratio= 4.472; 3.63). However mean reduction in FEV1 % and FVC% in old tubercular group (55.33±25.46; 60.51±31.07) compare to healthy control (109.63±18.92; 94.89±12.94) was statistically significant (p=<0.05). Conclusion: Old pulmonary tuberculosis significantly associated with diminution of airflow in the lungs, as well as significant risk factor for COPD , though less in compare to tobacco & biomass smoke. [A Agrawal, Natl J Integr Res Med, 2018; 9(4):1-6]
References
2. Curtis JK. The significance of bronciectasis associated with pulmonary tuberculosis. Am J Med.1957; 22:894-903.
3. Rosenzweig DY, Stead WW. The role of tuberculosis and other forms of bronchopulmonary necrosis in the pathogenesis of bronchiectasis. M Rev Respir Dis.1996; 93:769-85.
4. Sei Won Lee, Young Sam Kim, Dong-Soon Kim, Yeon-Mok Oh, Sang-Do Lee. The risk of obstructive lung diseases by previous pulmonary tuberculosis in a country with intermediate burden of tuberculosis. J Korean Med Sci. 2011; 26: 268–73.
5. Maguire GP, Anstey NM, Ardian M, Waramori G, Tjitra G , Kenangalem E et al. Pulmonary tuberculosis, impaired lung function, disability and quality of life in a high-burden setting. Int j Tuberc lung dis.2006; 13:1500–6.
6. Revathi M, Kutty TK, Annamalai N. Pulmonary Function in Rural Women Exposed to Biomass Fuel. J PulmonResp Med. 2012; 2:133.
Pérez-padilla R, pérez-guzmán C, báez-saldaña R, torres-cruzA.Cooking with biomass stoves and tuberculosis:a case control study. Int j tuberc lung dis 2001; 5:441–47.
8. Mishra VK, Retherford RD, Smith KR. Biomass Cooking Fuels and Prevalenceof Tuberculosis in India. Int J Infect Dis 1999; 3:119-129.
9. Taiwo OA, Cain HC. Pulmonary impairment and disability.Clin Chest Med.2002; 23: 841– 851.
10. Salvi SS, Barnes PJ.Chronic obstructive pulmonary disease in non-smokers. Lancet. 2009; 374 :733-43.
11. Vijayan VK, Kuppurao KV, Venkatesan P, Sankaran K, PrabhakarR.Pulmonary function in healthy young adult Indians in madras. Thorax.1990; 45:611-15.
12. Ranu H, Wilde M, Madden B. Pulmonary function tests. Ulster Med J 2011; 80:84-90.
13. Anno H, Tomashefski JF. Studies on the impairment of respiratory function in pulmonary tuberculosis. Am rev tuberc.1955; 71:333-48.
14. Hnizdo E, Vallyathan V. Chronic obstructive pulmonary disease due to occupational exposure to silica dust: a review of epidemiological and pathological evidence. Occup Environ Med 2003; 60:237–43.
15. Mohan A, Premanand R, Reddy LN, Rao MH, Sharma SK, Kamity R et al. Clinical presentation and predictors of outcome in patients with severe acute exacerbation of chronic obstructive pulmonary disease requiring admission to intensive care unit. BMC Pulmonary Medicine 2006, 6:27.
16. Rajasekaran S, SavithriS, Jeyaganesh D . Post-tuberculosis bronchial asthma. Ind.J Tub.2001; 48:139-42.
17. Chung KP, Chen JY, Lee CH, Wu HD, Wang JY, Lee LN .Trends and predictors of changes in pulmonary function after treatment for pulmonary tuberculosis. Clinics 2011; 66:549-556.
18. Plit ML, Anderson R, Rensburg CV, Shipp LP, Blott JA, Fresen JL et al.Influence of antimicrobial chemotherapy on spirometric parameters and pro-inflammatory indices in severe pulmonary tuberculosis. EurRespir J 1998; 12: 351–56.
19. Pasipanodya JG, McNabb SJ, Hilsenrath P, Bae S, LykensK, Vecino E E et al.Pulmonary impairment after tuberculosis and its contribution to TB burden. BMC Public Health 2010; 10:2.
20. Hnizdo E, Singh T, Churchyard G.Chronic pulmonary function impairment caused by initial
and recurrent pulmonary tuberculosis following treatment. Thorax. 2000; 55:32–38.
21. Rekha VB, Ramachandran R, Rao KK, Rahman F, adhilakshmi AR, kalaiselvi D et al. Assessment of long term status of sputum positive pulmonary TB patients successfully treated with short course chemotherapy. Indian J Tuberc 2009; 56:132-40.
22. Verma SK, Kumar S, Narayan KV, Sodhi R. Post tubercular obstructive airway impairment. Indian J Allergy Asthma Immunol 2009; 23: 95-99.
23. Menezes AMB, Hallal PC, Perez-Padilla R, Jardim JRB, Muin A, M.Lopez MV, et al. Tuberculosis and airflow obstruction: evidence from the PLATINO study inLatin America. EurRespir J 2007; 30: 1180–85.
24. Lee CH, Lee MC, Lin H, Shu C, Wang JY, Lee LN et al.Pulmonary tuberculosis and delay in anti-tuberculous treatment are important risk factors for chronic obstructive pulmonary disease. PLoS ONE May 2012 ;7 (e37978) :1-8.
25. Reddy TS, Guleria R, Sinha S, Sharma SK, Pande JN. Domestic cooking fuel and lung functions in healthy non-smoking women. Indian J Chest Dis Allied Sci 2004; 46: 85-90.
26. Panjwani AK, Ghazal S, Mahat R, Malik M, RizviN.Assessment of risk factors against severity of COPD in non-smokers. J Nepal Med Assoc 2013; 52:479-82.
27. Di Naso F.C., Pereira J.S., Schuh S.J., Unis G. Functional evaluation in patients with pulmonary tuberculosis Sequelae. Rev Port Pneumol. 2011; 17:216-21.
