Seroprevalence of HIV, Hbsag, HCV and Syphilis in Blood Donors At Tertiary Care Center, Ahmadabad

Authors

  • Dhara Darshan Patel Blood transfusion officer, The Gujarat Cancer & Research Institute, Ahmedabad-380016, Gujarat
  • Rima Rohan Kusumgar Assistant professor, head of blood bank, The Gujarat Cancer & Research Institute, Ahmedabad-380016, Gujarat

Keywords:

HIV, HBV, HCV, Syphilis, Transfusion Transmitted Infections.

Abstract

Background & objectives: Human Immunodeficiency Virus (HIV), Hepatitis B (HBV), Hepatitis C (HCV) and syphilis infections pose a great threat to blood safety. This study was done to investigate the seroprevalence of markers for transfusion transmitted infections (TTIs) among blood donors at Gujarat Cancer and Research Institute (GCRI) over a period of three years. Methods: This retrospective analysis was conducted from January 2012-December 2014 at GCRI, Ahmedabad, Gujarat, India. A strict donor selection criterion was employed during collection of blood, and each unit was screened for TTI using commercially available 4th generation enzyme-linked immunosorbent assay (ELISA) kits for HIV, 3rd generation ELISA kits for Hepatitis B surface antigen (HBsAg), and antiHepatitis C virus antibody (HCV). Screening for syphilis was performed by Rapid Plasma Reagin (RPR) test. All seropositive samples were repeat tested before discarding. Results: The data of 44017 donors [43094(97.9%) males and (2.10%) females] were analyzed. Replacement donations [26,214(59.55%)] represented the majority whereas, only (40.5%) donations were from the voluntary donors. Reactivity risk was near to double in male donors as compared to female donors.  A total of 44,017 donations were received, of which 40.5 % were voluntary donors and       (59.5 %) were replacement donors. Interpretation & conclusion: Every blood transfusion has a risk of TTI. Hepatitis B having the highest risk. This risk can be reduced by improving donor selection criteria, increased vigilance, use of sensitive tests in screening of blood, and by making mandatory testing of all donated blood for certain infectious diseases. [D Patel, Natl J Integr Res Med, 2018; 9(2):72-75]

Background & objectives: Human Immunodeficiency Virus (HIV), Hepatitis B (HBV), Hepatitis C (HCV) and syphilis infections pose a great threat to blood safety. This study was done to investigate the seroprevalence of markers for transfusion transmitted infections (TTIs) among blood donors at Gujarat Cancer and Research Institute (GCRI) over a period of three years. Methods: This retrospective analysis was conducted from January 2012-December 2014 at GCRI, Ahmedabad, Gujarat, India. A strict donor selection criterion was employed during collection of blood, and each unit was screened for TTI using commercially available 4th generation enzyme-linked immunosorbent assay (ELISA) kits for HIV, 3rd generation ELISA kits for Hepatitis B surface antigen (HBsAg), and antiHepatitis C virus antibody (HCV). Screening for syphilis was performed by Rapid Plasma Reagin (RPR) test. All seropositive samples were repeat tested before discarding. Results: The data of 44017 donors [43094(97.9%) males and (2.10%) females] were analyzed. Replacement donations [26,214(59.55%)] represented the majority whereas, only (40.5%) donations were from the voluntary donors. Reactivity risk was near to double in male donors as compared to female donors.  A total of 44,017 donations were received, of which 40.5 % were voluntary donors and       (59.5 %) were replacement donors. Interpretation & conclusion: Every blood transfusion has a risk of TTI. Hepatitis B having the highest risk. This risk can be reduced by improving donor selection criteria, increased vigilance, use of sensitive tests in screening of blood, and by making mandatory testing of all donated blood for certain infectious diseases. [D Patel, Natl J Integr Res Med, 2018; 9(2):72-75]

References

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Published

2018-05-16

How to Cite

Patel, D. D., & Kusumgar, R. R. (2018). Seroprevalence of HIV, Hbsag, HCV and Syphilis in Blood Donors At Tertiary Care Center, Ahmadabad. National Journal of Integrated Research in Medicine, 9(2), 72–75. Retrieved from http://nicpd.ac.in/ojs-/index.php/njirm/article/view/2350

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Original Articles