A Study of Etiological And Clinical Profile with associated Risk Factors of Deep Vein Thrombosis Detected In A Hospital Based Setting And Review of Literature of This As An Emerging Health Problem In Hospitals

Authors

  • Varsha S Dabadghao Professor, Department of Medicine, Dr. DY Patil Medical College, Hospital And Research Centre
  • Arundhati G Diwan Professor, Department of Medicine, Bharati Vidyapeeth University College of Medicine, Pune, India

Keywords:

deep vein thrombosis, hospital, immobilisation, health problem

Abstract

Introduction: Deep vein thrombosis (DVT) is one of the commonest thrombotic manifestations encountered in a hospital setting due to several causes. Method: This cross sectional, observational study was conducted in a tertiary care centre in Western India on 30 patients of proven deep vein thrombosis (DVT) to assess clinical profile, etiology and risk factors. Data was compiled in Epi info version 7 software for analysis. Results: The age group most commonly affected was 31-44 years (36.67%) with a male preponderance (80%). Most patients of DVT had Body Mass Index (BMI) 20-25(43.33%).The most common risk factor was immobilization (80%) out of which,50% patients were immobile due to coexisting medical problems and 30% due to fracture(13.3%) or other trauma(16.67%).Congestive cardiac failure (26.67%),diabetes with urosepsis who were in intensive care unit, one of whom had mechanical ventilation ( 20%)were the common medical morbidities. The remaining 20% had DVT due to mostly acquired and less commonly hereditary causes of hypercoagulability.83.33% patients had proximal DVT and the rest had distal DVT.13.33% patients had pulmonary embolism successfully treated. There were no deaths. Conclusion: In this study, as compared to others, younger economically productive age group with normal BMI or mild obesity is affected. The main risk factor is immobilisation due to medical comorbidities and traumatic injuries.

References

1. Silverstein MD,Heit JA, Mohr DN, Petterson TM, O'Fallon WM, Melton LJ 3rd.Trends in the incidence of deep vein thrombosis and pulmonary embolism:A 25 year population based study. Arch Intern Med.1998;158:585-93
2. Anderson FA Jr, Wheeler HB Goldberg RJ, Hosmer DW, Patwardhan NA, Jovanovic Bet al.A population based perspective of hospital incidence and case fatality rates of deep vein thrombosis and pulmonary embolism: The Worcester DVT study. Arch Intern Med. 1991;151:933-38
3. Spencer FA, Emery C, Joffe SW, Pacifico L, Lessard D, Reed G et al. Incidence rates, clinical profile, and outcomes of patients with venous thromboembolism. The Worcester VTE Study. J Thromb Thrombolysis. 2009; 28(4): 401–409.
4. Freedman JE, Loscalzo J . Arterial and venous thrombosis. In: Harrisson’s Principles of Internal Medicine,19th edition, New York; McGraw- Hills education ; 2015:740-45
5. McCollum P, Chetter M. Venous disorders. In:Bailey and Love’s Short Practice of Surgery,26th edition, Taylor and Francis group LLC;2013 :901-23
6. Heit JA, Silverstein MD Mohr DN, Petterson TM, O'Fallon WM, Melton LJ 3rd.Risk factors for deep vein thrombosis and pulmonary embolism: a population based case control study. Arch Intern Med. 2000;160:809-15
7. Pinjala R, ENDORSE study participants. Venous thromboembolism risk & prophylaxis in the acute hospital care setting (ENDORSE), a multinational cross-sectional study: Results from the Indian subset data. Indian J Med Res. 2012 Jul; 136(1): 60–67.
8. Wells PS, Anderson DR, Bormanis J ,Guy F, Mitchell M, Gray L, Clement Cet al. Value of assessment of pre test probability of deep vein thrombosis in clinical management. Lancet 1997;350:1795-98
9. Fowkes FJ, Price JF, Fowkes FG. Incidence of diagnosed deep vein thrombosis in the general population: a systematic review. Eur J Vasc Endovasc Surg 2003;25:1-5
10. Kaeron C et al.Natural history of venous thromboembolism.Semin Vasc Med 2001;1:27-37
11. Samama M.An epidemiologic study of risk factors for deep vein thrombosis in medical outpatients. Arch Intern Med 2000;160:3415-20
12. Sharma SK, Gupta V, Kadhiravan T, Banga A, Seith A, Kumar A et al. A prospective study of risk factor profile & incidence of deepvenous thrombosis among medically-ill hospitalized patients at a tertiary care hospital in northern India. Indian J Med Res 130;2009 : 726-730
13. Oren E., Smith N. L., Doggen C. J. M., Heckbert S. R. , Lemaitre R. N. Body mass index and the risk of venous thrombosis among postmenopausal women. Journal of Thrombosis and Haemostasis 2006;4: 2273–2275.
14. Asbeutah AM, Riha AZ ,Cameron JD, McGrath BP. Five year outcome study of deep vein thrombosis in the lower limbs. J Vasc Surg 2004;40:1184-89
15. Kazmers A, Groehn H, Meeker C. Acute calf vein thrombosis: outcomes and implications. Am Surg 1999;65:1124-27
16. Sachdev U, Teodorescu VJ, Shao M, Russo T, Jacobs TS, Silverberg D et al. Incidence and distribution of lower extremity deep vein thrombosis in rehabilitation patients: implications of screening. Vasc Endovasc Surg 2006;40:205-11
17. Goodacre S, Sutton AJ, Sampson FC. The value of assessment in the diagnosis of deep vein thrombosis. Ann Intern Med 2005;143:129-39
18. Rose SC, Zweibel WJ, Nelson BD .Distribution of acute lower extremity deep venous thrombosis in symptomatic and asymptomatic patients: imaging implications. J Ultrasound Med 1994;13:243-50
19. Deitscher SR, Caprini JA .Calf deep vein thrombosis should be treated with anticoagulation. Med Clin North Am 2003;87:1157-64
20. Lagerstedt CL, Olsson CG, Fagher BO, Oqvist BW, Albrechtsson U. Need for long term anticoagulation treatment in symptomatic calf vein thrombosis. Lancet 1985;2:515-18
21. Kohn H, Konig B. Incidence and clinical features of pulmonary embolism in patients with deep vein thrombosis:a prospective study. Eur J Nucl Med 1987;13(S):S 11-15

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Published

2018-05-16

How to Cite

Dabadghao, V. S., & Diwan, A. G. (2018). A Study of Etiological And Clinical Profile with associated Risk Factors of Deep Vein Thrombosis Detected In A Hospital Based Setting And Review of Literature of This As An Emerging Health Problem In Hospitals. National Journal of Integrated Research in Medicine, 9(2), 3–7. Retrieved from http://nicpd.ac.in/ojs-/index.php/njirm/article/view/2303

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Original Articles