Comparative Study to Test Efficacy Of Topical Permethrin And Oral Ivermectin In The Management Of Scabies- A Prospective Randomized, Single Blinded Controlled Study
Comparative Study to Test Efficacy Of Topical Permethrin And Oral Ivermectin
DOI:
https://doi.org/10.70284/njirm.v5i1.2279Keywords:
Permethrin, ivermectin, scabiesAbstract
Background : Scabies is a contagious intensely pruritic ectoparasitic infestation caused by mite Sarcoptes scabiei hominis. Various treatment modalities are available but topical permethrin and oral ivermectin is considered to be safe and effective in the treatment of scabies. Aim : To compare the efficacy of topical permethrin and oral ivermectin in the treatment of scabies. Material And Methods : It was an interventional study conducted in the out patient department Rohilkhand Medical College and Hospital.100 clinically diagnosed cases of scabies belonging to either sex and from 10-60 yrs of age were selected and divided into two groups. Oral ivermectin was given to group A and topical 5% permethrin was given to the group B and follow up at 1, 2 and 4 weeks of interval. at each visit and cure rate was compared. Results : Permethrin showed the efficacy of 89.1% in completely clearing scabietic lesions at 4 week interval as compared to oral ivermectin which showed 78.5% clearing of lesions in 4 weeks. Thus both the treatment modalities were almost equally effective. Conclusion : Oral ivermectin and topical permethrin both are almost equally effective but permethrine has rapid onset of action.
References
2. Orkin M, Maibach HI. Scabies and pediculosis. In: Freedberg ZIM, Eisen AZ, Wolff K et al., eds. Fitzpatrick's Dermatology in General Medicine, 5lh edn. New York: McGraw-Hill; 1999. P. 2677-84.
3. Burrs DA. Diseases caused by arthropods and other noxious animals. In: Burns T, Breathnach S, Cox N, Griffiths C, editors. Rook’s Textbook of Dermatology. Blackwell Science; 2004. P. 39.42.
4. Terri Meinking, David Taplin and Maureen Vicaria. Pediatric dermatology 4th edition, 2011. P . 1556-72.
5. Terri L Meinking, Craig N Burkhart and George Elgart. Jean Bolognia 2nd Edition, 2008. P .1291-95.6. Walker GJA, Johnstone PW. Interventions for treating scabies (Cochrane review) .2002; 4. Available from:http://www.updatesoftware.com/ abstracts/ab000320.htm.)
7. Akhtar SJ, Maan MA, Iqbal J, Kapadia N. Treatment of scabies simplified. J Pak Assoc Dermatol 2007; 17: 240-9.
8. Mark S. Fradin. Comprehensive Dermatologic Drug Therapy, Stephen E. Wolverton 2nd edition. P . 795-796.
9. Usha V, Gopalakrishnan-Nair TV. A Comparative study of oral ivermectin and topical permethrin
creams in treatment of scabies. J Am Acad Dermatol 2000; 42: 236-40.
10. Currie BJ, McCarthy JS. Permethrin and ivermectin for scabies. N Engl J Med 2010;362:717-25.
11. Schultz MW, Gomez M, Hansen RC, Mills J, Menter A, Rodgers H, et al. Comparative study of 5% permethrin cream and 1% lindane lotion for the treatment of scabies. Arch Dermatol 1990;126:167-70.
12. Campbell WC. Ivermectin, an antiparasitic agent. Med Res Rev 1993;13:61-79.
