Antibiotic Resistance Among Uropathogens : A Challenge
Antibiotic Resistance Among Uropathogens : A Challenge
Keywords:
Antibiotic resistance , Uropathogens , UTIAbstract
Background objectives: Urinary tract infection (UTI) is among the most common infection described in outpatient setting & hospital patients. The increasing prevalence of antimicrobial resistance is a major health problem & is associated with high morbidity & mortality. So ,a retrospective study of one year was conducted to know the current scenario of antibiotic resistance among uropathogens in Central India. Material &Methods: Fresh midstream urine samples were aseptically collected in sterile containers. Each sample was plated on 5% sheep blood agar & MacConkey agar plates using a standard loop technique & the growth was processed by standard bacteriological technique. After biochemical identification, antimicrobial sensitivity testing was done for the isolates using Kirby-Bauer methods on Mueller-Hinton agar & results were interpreted as per the CLSI 2011 guidelines. Results: The commonest uropathogen obtained was E.coli (56.1%) followed by the klebsiellae species.(27.6%).Among gram- positive organism ,S.aureus (1.9%) was most prevalent uropathogen obtained. Among ,Gram positive organism ,the maximum resistance was observed towords Penicillin G followed by erythromycin.All enterococcal isolates showed maximum resistance to commonly used urinary antibiotic i.e norfloxacin & nitrofurantoin. All Gram-positive isolates were 100% sensitive to vancomycin & Teicoplanin These isolates showed resistance to all the commonly used antibiotics. The main challenge is the multidrug resistance (i.e resistance to more than 3 drugs) shown by all the isolates. All the Gram-negative isolates showed maximum sensitivity to amikacin & imipenem. Interpretation & Conclusion :These findings call for wiser use of antimicrobial agents & their continous in vitro monitoring.
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