Evaluation Of Serum Calcium And Lipid Profile In Women With Pre-Eclampsia, Eclampsia And Normal Pregnancy
Serum Calcium And Lipid Profile In Preeclampsia
Keywords:
pre-eclampsia, eclampsia, calcium, lipid profile, normal pregnancyAbstract
Introduction: Background & objective: Pre-eclampsia and eclampsia are the most common obstetrical complications during pregnancy. The objective of this work was to quantitate and find significance of serum calcium and lipid profile levels in pre-eclamptic and eclamptic pregnancy in comparison with normal pregnancy. Methods: Study includes 105 subjects divided into three groups. Estimation of Calcium, Triglycerides, Total-Cholesterol and HDL-C were analyzed by O-Cresolphthalein-Complexone, GPO-PAP, CHOD-PAP and Phosphotungstic acid precipitation method, using Erba Chem-5 plus semi-autoanalyser. Results: Mean serum calcium and HDL-C levels were significantly decreased in group-II and group-III in comparison to group-I,p<0.05. The mean triglyceride, VLDL-C and LDL-C levels were significantly increased in group-II as compared to group-I,p<0.05. There was no difference in the mean values of total-cholesterol between cases (group-II and group-III) and control (group-I),p>0.05; but the mean level of VLDL-C was higher in group-III in comparison to group-I,p<0.05. Non significant (p>0.05) difference was found in mean values of triglyceride and LDL-C in group-III cases in comparison to group-I. Interpretation & conclusion: Women having pre-eclampsia and eclampsia had low levels of serum calcium and disturbed lipid profile. These levels may have cause and effect relationship with these disorders.
References
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30. Standley CA, Whitty JE, Mason BA, Cotton DB. Serum ionized magnesium levels in normal and pre-eclamptic gestation. Obstet Gynecol. 1997; 89:24-7.
31. Ingec M, Nazik H, Kadanali S. Urinary calcium excretion in severe pre-eclampsia and eclampsia. Clin Chem Lab Med 2006; 44: 51-3.
32. Powers RW, Evans RW, Majors AK. Plasma homocysteine concentration is increased in preeclampsia and is associated with evidence of endothelial activation. Am J Obstet Gynecol. 1998; 179:1605-1611.
33. Enquobahrie, DA, Williams MA, Butler CL, Miller RS, Luthy DA. Maternal plasma lipid concentrations in early pregnancy and risk of
preeclampsia. Am J hypertens. 2004; 17 (7): 574-81.
34. Jayanta, D., K.M. Ananda and K.S. Pradip. Study of serum lipid profile in PIH. Indian J. Clin. Biochem. 2006; 21: 165-168.
35. Sattar, N., A. bendomir, C. Berry, J. Shepherd, I. Greer and C. J. Packard. Lipoprotein subfraction concentrations in pre-eclampsia: Pathogenic parallels to atherosclerosis. Obstet. Gynecol. 1997; 89: 403-408.
36. Gratacos E, casals E, Gomez O, et. al. Increased susceptibility to low density lipoprotein oxidation in women with a history of pre-eclampsia. Br J of Obst & Gynae. 2003; 110(4): 400-4.
37. Shalini Maksane, Rashmi Ranka, Nitin Maksane and Anjali Sharma. Study of serum lipid profile and magnesium in normal pregnancy and in preeclampsia: A case control study. Asian Journal of Biochemistry. 2011; 6(3): 228-239.
38. Hubel CA, Margret, Mclarghlin, Evans RW. Fasting serum triglycerides, FFA and malandialtehde are increased in preeclampsia, are positively correlated and decrease within 48 hr post partum. Am. J Obstet Gynecol 1996; 174:975-982.
2. Habli M, Levine RJ, Qian C, Sibai B. Neonatal outcomes in pregnancies with preeclampsia or gestational hypertension and in normotensive pregnancies that delivered at 35, 36, or 37 weeks of gestation. Am J Obstet Gynecol. 2007; 197(4):406 e401-407.
3. Ananth CV, Basso O: Impact of pregnancy-induced hypertension on stillbirth and neonatal mortality. Epidemiology 2010; 21(1):118-123.
4. Cunningham FG, Leveno KJ, Bloom SL, Hauth JC, Gilstrap LC, Wenstrom KD. Hypertensive disorders in pregnancy. In: Cunningham FG, Leveno KJ, Bloom SL, Hauth JC, Gilstrap LC, Wenstrom KD (eds.) Williams obstetrics, 22nd edn. McGraw-Hill, New York. 2005; pp 761–808.
5. Wotgkitisophon K, Phupong V, Yamasmit W, Pansin P, Tannirandorn Y, Charoenvidhya D. Correlation of 4- and 24- hour urine protein in women with initially diagnosed hypertensive disorders in pregnancy. J Med Assoc Thai 2003; 86:529-534.
6. Piercy CN. In: handbook of Obstetric medicine. Isis Medical Media, oxford, 1997.
7. Swain S, Ojha KN, Prakash A. Maternal and prenatal mortality due to eclampsia. Indian pediatr 1993; 30(6): 771-73.
8. Surraya Halimi, Syed Muhammad Ashhad Halimi. Eclampsia and its association with external factors. J Ayub Med Coll Abbottabad. 2010; 22 (3).
9. Indumati V et al. Role of serum electrolytes in PIH; Journal of Clinical and Diagnostic Research. 2011 Feb, Vol-5(1):66-69.
10. Belizan J.M., Villar. J., Repke J. The relationship between calcium intake and pregnancy induced hypertension: up-to-date evidence. Am. J. Obstet. Gynecol. 1988; 158: 898-902.
11. Ortega RM, Martinez RM, Lopez-Sobaler AM, Andres P, Quintas ME. Influence of calcium intake on gestational hypertension. Ann Nutr Metab. 1999, 43(1):37-46.
12. Hofmeyr GJ, Duley L, Atallah A. Dietary calcium supplementation for prevention of pre-eclampsia and related problems: a systematic review and commentary. B jog 2007; 114(8):933-943.
13. Hofmeyr GJ, Atallah AN, Duley L: Calcium supplementation during pregnancy for preventing hypertensive disorders and related problems. Cochrane Database Syst Rev 2006; 3:CD001059.
14. Davidge ST, Hubel C A, Brayden R D. et al. Sera antioxidant activity in uncomplicated and preeclamptic pregnancies. Obstetrics and Gynecology. 1992; 79: 897-901.
15. Kokia E, Barkai G, Reichman B., et al. Maternal serum lipid profile in pregnancies complicated by hypertensive disorders. Journal of Perinatal Medicine. 1990; 18:473-478.
16. Kashinakunti S.V. et al. Lipid Profile in Pre-eclampsia- A Case Control Study. Journal of Clinical and Diagnostic research. 2010; 4:4, 2748-2751.
17. Karl W, Birgit W, Michael M. H et al. Triglyceride Rich Lipoproteins Are Associated with Hypertension in Preeclampsia. The Journal of Clinical Endocrinology & Metabolism 2003; 88(3):1162-1166.
18. Gindler EM & King J.D. Am J. CIin Pathol. 1972; 58: 376.
19. Allian, C.C., L.S.Poon, C.S.Chan, W.S.Richmond and P.C. Fu, Enzymatic determination of total serum cholesterol. Clin.Chem. 1974; 20: 470:475.
20. McGOWAN, M. W. ARTISS, J. D. STRANBERG, D. R. ZAK, B. A. Peroxidase coupled methodfor the colorimetric determination of serum Triglycerides. Clin.Chem 1983: 29, 538-542.
21. Burstein M., Scholnic H. R., Morfin R. J. Lipid Res. 1970
22. Omole-ohonsi et al. pre-eclampsia – A study of risk factors. Nigerian Medical Practitioner 2008; 53 (6): 99-102.
23. Surray Halimi, Syed Muhammad Ashad Halmi. Eclampsia and its association with external factors. J Ayub Med Coll Abbottabad. 2010; 22(3) : 110-113.
24. Mosammat Rashida Begum, Anowara Begum, Ehsan Quadir, Sayeba Akhter, latifa Shamsuddin. Eclampsia, still a problem in Bangladesh. Med Gen Med 2004; 6(4): 52.
25. NAF Islam et al. Study of serum lipid profile in pre-eclampsia and eclampsia. Faridpur Med. Coll. J. 2010; 5(2): 56-59.
26. Idogun E.S et al. extra cellular calcium and magnesium in preeclampsia and eclampsia. African journal of reproductive health 2007; 11(2): 89-94.
27. J. Moodley et. al. Serum calcium ion concentrations in eclampsia. South African Medical research Council, Johannesburg 1987; 72: 382-385.
28. Punthumapol C et al. J Med Assoc Thai. 2008; 91 (7): 968-973.
29. Belizan J.M., Villar. J., Repke J. The relationship between calcium intake and pregnancy induced hypertension: up-to-date evidence. Am. J. Obstet. Gynecol. 1988; 158: 898-902.
30. Standley CA, Whitty JE, Mason BA, Cotton DB. Serum ionized magnesium levels in normal and pre-eclamptic gestation. Obstet Gynecol. 1997; 89:24-7.
31. Ingec M, Nazik H, Kadanali S. Urinary calcium excretion in severe pre-eclampsia and eclampsia. Clin Chem Lab Med 2006; 44: 51-3.
32. Powers RW, Evans RW, Majors AK. Plasma homocysteine concentration is increased in preeclampsia and is associated with evidence of endothelial activation. Am J Obstet Gynecol. 1998; 179:1605-1611.
33. Enquobahrie, DA, Williams MA, Butler CL, Miller RS, Luthy DA. Maternal plasma lipid concentrations in early pregnancy and risk of
preeclampsia. Am J hypertens. 2004; 17 (7): 574-81.
34. Jayanta, D., K.M. Ananda and K.S. Pradip. Study of serum lipid profile in PIH. Indian J. Clin. Biochem. 2006; 21: 165-168.
35. Sattar, N., A. bendomir, C. Berry, J. Shepherd, I. Greer and C. J. Packard. Lipoprotein subfraction concentrations in pre-eclampsia: Pathogenic parallels to atherosclerosis. Obstet. Gynecol. 1997; 89: 403-408.
36. Gratacos E, casals E, Gomez O, et. al. Increased susceptibility to low density lipoprotein oxidation in women with a history of pre-eclampsia. Br J of Obst & Gynae. 2003; 110(4): 400-4.
37. Shalini Maksane, Rashmi Ranka, Nitin Maksane and Anjali Sharma. Study of serum lipid profile and magnesium in normal pregnancy and in preeclampsia: A case control study. Asian Journal of Biochemistry. 2011; 6(3): 228-239.
38. Hubel CA, Margret, Mclarghlin, Evans RW. Fasting serum triglycerides, FFA and malandialtehde are increased in preeclampsia, are positively correlated and decrease within 48 hr post partum. Am. J Obstet Gynecol 1996; 174:975-982.
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Published
2013-08-31
How to Cite
Das, D., Mallick, D. K., Samanta, M. S., & Ghosh, D. A. (2013). Evaluation Of Serum Calcium And Lipid Profile In Women With Pre-Eclampsia, Eclampsia And Normal Pregnancy: Serum Calcium And Lipid Profile In Preeclampsia. National Journal of Integrated Research in Medicine, 4(4), 85–91. Retrieved from http://nicpd.ac.in/ojs-/index.php/njirm/article/view/2212
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