Study Of Prescribing Patterns Of Antimicrobial Agents In The Medicine Department At Tertiary Teaching Care Hospital In Gujarat

Study Of Prescribing Patterns Of Antimicrobial Agents

Authors

  • Dr. Vipul Prajapati
  • Dr. J.D. Bhatt
  • Dr.Mukeshkumar B Vora

DOI:

https://doi.org/10.70284/njirm.v3i3.2052

Keywords:

Anti-microbial agents, internal medicine, prescription pattern, retrospective study

Abstract

Pharmacology, Medical college, Baroda., *** Assistant Professor, Department of Pharmacology, Govt. Medical College,Bhavnagar
Abstracts: Background: Prescription of drugs which needs to be continuously assessed and refined accordingly. It is not only reflects the physician’s knowledge of pharmacology and pathophysiology of diseases but also his/her skill in diagnose and attitude towards selecting the most appropriate cost effective treatment. Antimicrobials are among the most commonly prescribed drugs in hospital. As per literature, they account for nearly 20% of all new and repeat prescription each year. Hospital purchase of these drugs is thought to be about 25 to 30 % of the total annual drug budget. Such studies have been sparse from Gujarat and hence, this study was undertaken. Objective: This study was carried out to find out the prescribing patterns of antimicrobial drugs in the medicine department at tertiary teaching care hospital, Vadodara (Gujarat). Methods: Retrospective study was carried out by collecting 350 prescriptions containing antimicrobial agents of the indoor patients admitted (Oct 2005 to June 2006) in the wards of medicine department at Sir Sayajirao General (SSG) Hospital, Vadodara to assess the prescribing patterns of antimicrobial agents. All the information about drugs details were recorded in pre-tested proforma. Results: In our study, total 350 prescriptions containing 539 antimicrobial drugs were prescribed in-patients during study. Of them β –lactam (except CP) (159; 29.49%) and cephalosporin (156; 28.94%) groups were commonly prescribed. Average number of antimicrobials per prescription was 1.54.Out of 539 antimicrobial agents prescribed, 486 (90.16%) were prescribed by generic name, while only 53(9.53%) were prescribed by trade name. Total numbers of antimicrobial prescribed by parenteral route were 313(58.07%), while 226(41.93%) antimicrobial agents were prescribed by oral route. Conclusion: Results indicate that noticeable controlled over the prescribing habits of the physicians for indoor patients at our hospital. It is suggested that further detail analysis to judge the rationality of the therapy is necessary

References

1. Benet LZ. Principles of prescription order writing and patients compliance instructions. In: Goodman AG, Rall TW, Nies AS, Taylor P, Eds. Goodman and Gilman’s pharmacological basis of therapeutics, 8th Eds. New York: Pergamon Press Inc; 1991. 1640.
2. Col NF, O Conner RW. Estimating worldwide current antibiotic usage. A report of task force. Int Rev infects Dis 1987;9:232-43.
3. Watcher DA, Joshi MP, Rimal B. Antibiotic dispensing by drug detailers in Kathmandu, Nepal. Trop Med Int Health 1999; 4:782-8.
4. McGowan JE. Antimicrobial resistance in hospital organisms and is relation to antibiotic use. Rev Infect Dis 1983; 5:1033- 48.
5. Reichler MR, Allphin AA, Breiman RF. The spread of multiply resistant streptococcus pneumonia at a day care Center in Ohio. J Infect Dis 1992; 166:1346-53.
6. Craig WA, Uman SJ, Shaw WR, Ramgopal V, Eagan LL, Leopold ET. Hospital use of antimicrobial drugs. Ann int Med1978; 89:793-5.
7. Hortal M, Algorta G, Bianchi I. Capsular type distribution and susceptibility to antibiotics of Streptococcus pneumonia clinical strains isolated from Uruguayan children with systemic infections: Pneumococcus Study Group. Microb Drug Resist 1997;3:159-63.
8. Baquero F,Barrett JF, Courvalin P. Epidemiology and mechanisms of resistance among respiratory tract pathogens. Clinical microbiology and infection 1998;4:19-26.
9. Magee JT, Pritchard EL, Fitzgerald KA, Howard AJ. Antibiotic prescribing and antibiotic resistance in community pract. Brit Med J 1999;319:1239-40.
10. Seppala H, Klaukka T, Vuopio-varkila J.The effect of changes in the consumption of macrolides antibiotics on erythromycin resistance in-group a streptococci in Finland: Finish study group for antimicrobial resistance. N Eng J Med 1997; 337:441-6.
11. Finkelstein JA, Metlay JP, Davis R. Antimicrobial use in defined populations of infants and young childre12. Mainous AG, Hueston WJ, Love MM. An evaluation of statewide strategies to reduce antibiotic overuse. Fam Med 2000;32: 22-9.
13. Cars H,Hakansson A. To prescribe or not to prescribe antibiotics.:District physicians’ habits vary greatly and are difficult to change. Scand J Prim Health Care 1995; 13: 3-7.
14. O’Connor S, Rifkin D. Physician control of paediatric antimicrobial use in Beijing, China and its rural and environs. Paed Infect Dis J 2001; 20:679-84.
15. WHO. How to investigate drug use in health facilities: selected drug use indicator, Geneva,World Health Organization, 1993; WHO/DAP/93 1993; 1:1-87.
16. Laporte JR. Towards a healthy use of pharmaceuticals. Development dialogue 1985; 2:48-55.
17. Chambers HF. Antimicrobial: General considerations.In: Hardmam JG, Limbird LE (Eds). Goodman and Gillman’s pharmacological basis of therapeutics, 10th ed. McGraw Hill; 2001. p.1152-1153.
18. Rehana HS, Nagarani MA, Moushumi R. A study of the drug prescribing pattern and use of antimicrobial agents of a tertiary care teaching hospital in Eastern Nepal. Indian J Pharmacol 1998; 30: 175-180.
19. World Health Organization, 2000.Health situation in Asia region, 185.
20. Gupta N,Sharma D,Garg SK. Auditing of prescriptions to study utilization of antimicrobials in a tertiary hospital. Indian J of Pharmacol 1997; 29: 411-415.
21. Kass, EH. Antimicrobial drug usage in general hospitals in Pennsylvania. Ann Int Med 1978; 89:800-801.
22. Ellner PD, Fink DJ, Neu HC, Parry MF. Epidemiological factors affecting antimicrobial resistance of common bacterial isolates. J Clin Microb 1987; 25: 1668-74.
23. Shewade DG, Pradhan SC. Auditing of prescriptions in government teaching hospital and four retail medical stores in Pondicherry. Indian J Pharmacol 1998; 30: 408-410.
24. Nies SA. Principles of therapeutics In:Gilman GA, Rall WT, Nies SA, Taylor P, (Eds). The
pharmacological basis of therapeutics, 8th ed. New York:Pergamon Press;1990.62-83.
25. Hogerzeil HV. Walker GA, Sellanic AO, Fernoado G. Impact of essential drug programmes on availability and rationals of drugs Lancet 1989; 1:141-2.
26. Tomson G. Drug utilization studies in sri Lanka -Towards an understanding of medicine in society. Thesis, Karolinska Institute, Stockholm, Sweden 1990.
27. Kunin CM, Tupasi T, Craige WA. Use of antibiotics a brief exposition of the problem and some tentative solution. Ann Int Med 1973;79: 555-60.

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Published

2012-08-31

How to Cite

Prajapati, D. V., Bhatt, D. J., & Vora, D. B. (2012). Study Of Prescribing Patterns Of Antimicrobial Agents In The Medicine Department At Tertiary Teaching Care Hospital In Gujarat: Study Of Prescribing Patterns Of Antimicrobial Agents. National Journal of Integrated Research in Medicine, 3(3), 129–136. https://doi.org/10.70284/njirm.v3i3.2052

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