Pulmonary Functions in Different Phases of Menstrual Cycle and its Relation with Serum Progesterone levels.
Pulmonary Functions in Different Phases of Menstrual Cycle & Serum Progesterone levels.
Keywords:
adolescent girls, pulmonary function, menstrual cycle, serum progesteroneAbstract
Background & objectives: Cyclical changes in the hormonal levels determine different phases of
menstrual cycle. These variations in hormonal levels are also responsible for variations in functional
parameters of many systems in the body. Many studies have highlighted the changes in respiratory
parameters in different phases of menstrual cycle. In this study, we have explored the factors that influence
lung function in adolescent girls focusing on the hormonal factors related to the menstrual cycle. Methods: 36
adolescent girls with normal menstrual cycle consented for the study. Pulmonary functions and serum
progesterone were measured during follicular and secretory phase of menstrual cycle after a detailed
menstrual history and screening for medical illness. Results : show a significantly higher serum progesterone
and FVC, FEV1 and PEFR during secretory phase. There was a strong positive correlation of Serum
progesterone in secretory phase with FVC and negative correlation with FEV1%. Interpretation & conclusion:
This improvement of pulmonary function during secretory phase is due to increase in serum progesterone
levels which have a dual effect of overall smooth muscle relaxation and hyperventilation. Supplement of
progesterone may be useful to avert premenstrual asthma and enhance the performance.
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