Randomized Comparative Study of Intrathecal Administration of Dexmedetomidine-Fentanyl for Labour Pain
Randomized Comparative Study of Intrathecal Administration of Dexmedetomidine-Fentanyl for Labour Pain
Keywords:
Combine, Dexmedetomidine, Fentanyl, Labour PainAbstract
Introduction: Dexmedetomidine used in pregnancy as it does not significantly cross the placenta due to its high placental retention. Also it has no adverse effects on mother or fetus in many studies. Our purpose was to evaluate the effect of combination of IT dexmedetomidine and fentanyl on maternal and neonatal outcomes during labour in comparison to IT dexmedetomidine or IT fentanyl. Methods: Age groups between 20 – 40 years were included in the study. A total of 150 patients were included in the study. All the included patients were scheduled for normal vaginal delivery with uncomplicated delivery. Any patients with liver, kidney disease, cardiac problem, any allergy to local anesthesia, fetal compromise or patient refusal were excluded from the study. The informed consent was taken from all the patient included in the study. Results: Onset of analgesia was faster and duration of analgesia was longer in group C than in the two other groups (p-value <0.001), 18 patients in A group, 19 patients in group B and 15 patients in group C needed top-ups of 10ml of 0.125% bupivacaine till delivery of baby. Discussion & Conclusion: Our study concluded that Addition of 5 μg intrathecal dexmedetomidine to 10 μg fentanyl prolonged the duration of analgesia. The combination decreases the incidence of side effects in comparison to IT 10 μg dexmedetomidine or IT 20 μg fentanyl alone.
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