Rapid Diagnostic Test for the Discrimination between Types of Meningitis
Rapid Diagnostic Test for the Discrimination between Types of Meningitis
Keywords:
ADA, CSF, Evaluation, MeningitisAbstract
Background & Aim: there is a need for an easy and comprehensive test to diagnose Acute Bacterial Meningitis timely. Routine use of CSF CRP in diagnosing acute bacterial meningitis could be a rapid, reliable and easy method for diagnosis of meningitis. Hence the aim of this study is to evaluate whether C-reactive protein and adenosine deaminase levels could be used to differentiate the various types of meningitis in adults. Methods: Patients were divided into three groups. Group I comprised of 10 cases of pyogenic meningitis based on clinical features usually acute in onset. They were associated with otitis media, sinusitis and signs of meningeal irritation. Group II comprised of 62 cases of tuberculosis meningitis, which included insidious in onset, maybe associated with TB of other organs or signs of meningeal irritation. Group III comprised of 18 cases of viral meningitis based on clinical presentation, usually acute in onset with signs of meningeal irritation. Results: CRP level in pyogenic meningitis cases were found to be significantly higher as compared to the other two groups. It was found that none of the cases of pyogenic and viral meningitis had positive ADA values. Conclusion: On the basis of above based result and discussion it was concluded that ADA activity in CSF is elevated in tuberculous meningitis. CSF-CRP levels can reliably discriminate between pyogenic and non-pyogenic meningitis.
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