Study of Coulter Indices After Oral & Parenteral Iron Therapy In Iron Deficiency Anaemia
Study of Coulter Indices After Oral & Parenteral Iron Therapy In Iron Deficiency Anaemia
DOI:
https://doi.org/10.70284/njirm.v7i2.1370Keywords:
Coulter indices, Severe Iron deficiency Anaemia, Oral iron, Iron SorbitolAbstract
iron therapy is considered to be better for rapid correction of anaemia, than oral form. Methodology: The
haematological response, of 47 severely iron deficient patients, to orally administered iron was compared to that of
40 patients given parenteral iron sorbitol. The haematological response was assessed with the help of Coulter
indices. Results: No significant difference in the rate of change of haematological parameters was observed in oral
& parenteral form of iron therapy. Conclusion: Earliest response & completion of therapy both can be judged by
Red cell Distribution Width (RDW) levels in either form of iron replacement. Red Blood Cells histogram best reflects
an evolution of response and overt attainment of normal contours & placement reflects the adequacy of treatment.
[Hartalkar A NJIRM2016; 7(2):113-118]
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8. Kamolafe JO, Kuti O, Ijadunola KT. A comparative
study between intramuscular iron dextran & oral
ferrous sulphate in the treatment of iron
deficiency anaemia in pregnancy. Journal of Obst &
Gynecology 2003: 123 (6) : 628-631
9. Ogunbode O, Oluboyede OA, Ayeni O The
treatment of iron deficiency anaemia with a new
intramuscular iron preparation (Ferastral).
Scandinavian Journal of Haematology (1977) Suppl.
32: 364-371.
10. World Health Organisation (WHO) 1993 Prevention
and treatment of anaemia. WHO / FHE / MSM/ 93.
Geneva.
11. Thompson RB & Proctor SJ. Iron deficiency. In: A
short textbook of Haematology, edited by
Thompson RB & Proctor SJ. 6th edition. Pp 160-
177. Hong Kong, Longman group Ltd.
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review. Gujarat medical journal 2000;57,(1):5-12.
13. Sheshadri S. Nutritional anaemia & malnutrition in
south Asia, A regional profile. UNICEF - Regional
office for health Asia, Kathmandu publication,
1997; No. 5: 75-124.
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therapeutics. Practitioner's section of Indian
Journal of Medical research 1961; 187: 224-230.
15. Mehta BC. Optimal dose of oral iron for IDA. Drugs
& therapeutics 1985; 1: 30-31.
16. Goodman & Gillman. Pharmacological basis of
therapeutics. 9th edition publisher.
17. Amol Hartalkar. The study of coulter indices in
response to oral iron replacement & its
comparison with parenteral iron therapy in severe
iron deficiency anemia. A thesis, 2004.
(Unpublished data)
18. Swan HT, Jowett GH. Treatment of iron deficiency
with ferrous fumerate. BMJ 1959; Vol. 1:781-787.
19. Bessman D. Erythropoeisis during recovery from
iron deficiency - Normocyte & macrocyte. Blood
Dec 1977; 50(6): 987-993.
20. Clark W, Maurice P, William Castle. Quantitative
aspects of iron deficiency in hypochromic anemia.
Journal of clinical investigation 1932; 11: 91.
21. Nils SE, Anderson MD. Clinical investigation on new
intravascular hematinics. British medical journal
1961;29. Vol. 2: 21- 27.
22. Roger Hamstra, Mathew Block. Erythropoesis in
response to blood loss in man. Journal of applied
physiology 1969; 4:503-507.
23. Schocket Alan L, Hamstra Roger D, Block Mathew
H. Intravenous iron dextrean in clinical medicine.
JAMA 1980; 243 (17):1726-1733
24. Lane RS. Change in plasma transferrin level
following administration of iron. British journal of
haematology 1966; 12: 249-258.
25. Mehta BC. Quarterly medical review Jan-March
2001; 52: (1) Page 9.
prevalence of anemia in world'. World health
statistics 1984; 38:302-316.
2. Sportor, R.F. Intravenous Iron as alternate to blood
transfusion in late pregnancy. Amer J Obstet Gynec
1957; 73: 338-340
3. McCurdy PR. Oral & parenteral iron therapy. JAMA
1965; 191(10): 155-158.
4. Pritchard JA. Response to iron in iron deficiency:
Anemia due to gynecological disease JAMA 1961;
175: 478-482.
5. Al Momen AK, Al Meshari, Al Nuail, Saddique A et
al Intravenous iron sucrose complex in treatment
of iron deficiency & anemia during pregnancy. Eur
J Obst & Gynecology Reprod Biol 1996; 69: 121-4.
6. Bayoumeu F. Iron therapy in iron deficiency
anemia in pregnancy: Intravenous route versus
oral route. American journal of Obst & Gynecology
2002;186 (3): 518-522.
7. Singh K, Yong YF, Kuperan P. A comparison
between iron polymaltose complex & oral ferrous
fumerate in the treatment of iron deficiency
anemia in pregnancy. Eur J of Hematology 1998;
60: 119-124.
8. Kamolafe JO, Kuti O, Ijadunola KT. A comparative
study between intramuscular iron dextran & oral
ferrous sulphate in the treatment of iron
deficiency anaemia in pregnancy. Journal of Obst &
Gynecology 2003: 123 (6) : 628-631
9. Ogunbode O, Oluboyede OA, Ayeni O The
treatment of iron deficiency anaemia with a new
intramuscular iron preparation (Ferastral).
Scandinavian Journal of Haematology (1977) Suppl.
32: 364-371.
10. World Health Organisation (WHO) 1993 Prevention
and treatment of anaemia. WHO / FHE / MSM/ 93.
Geneva.
11. Thompson RB & Proctor SJ. Iron deficiency. In: A
short textbook of Haematology, edited by
Thompson RB & Proctor SJ. 6th edition. Pp 160-
177. Hong Kong, Longman group Ltd.
12. K Madhvan Nair NIN, 'Iron in health & disease' – A
review. Gujarat medical journal 2000;57,(1):5-12.
13. Sheshadri S. Nutritional anaemia & malnutrition in
south Asia, A regional profile. UNICEF - Regional
office for health Asia, Kathmandu publication,
1997; No. 5: 75-124.
14. John F Wilkinson. Iron therapy Current
therapeutics. Practitioner's section of Indian
Journal of Medical research 1961; 187: 224-230.
15. Mehta BC. Optimal dose of oral iron for IDA. Drugs
& therapeutics 1985; 1: 30-31.
16. Goodman & Gillman. Pharmacological basis of
therapeutics. 9th edition publisher.
17. Amol Hartalkar. The study of coulter indices in
response to oral iron replacement & its
comparison with parenteral iron therapy in severe
iron deficiency anemia. A thesis, 2004.
(Unpublished data)
18. Swan HT, Jowett GH. Treatment of iron deficiency
with ferrous fumerate. BMJ 1959; Vol. 1:781-787.
19. Bessman D. Erythropoeisis during recovery from
iron deficiency - Normocyte & macrocyte. Blood
Dec 1977; 50(6): 987-993.
20. Clark W, Maurice P, William Castle. Quantitative
aspects of iron deficiency in hypochromic anemia.
Journal of clinical investigation 1932; 11: 91.
21. Nils SE, Anderson MD. Clinical investigation on new
intravascular hematinics. British medical journal
1961;29. Vol. 2: 21- 27.
22. Roger Hamstra, Mathew Block. Erythropoesis in
response to blood loss in man. Journal of applied
physiology 1969; 4:503-507.
23. Schocket Alan L, Hamstra Roger D, Block Mathew
H. Intravenous iron dextrean in clinical medicine.
JAMA 1980; 243 (17):1726-1733
24. Lane RS. Change in plasma transferrin level
following administration of iron. British journal of
haematology 1966; 12: 249-258.
25. Mehta BC. Quarterly medical review Jan-March
2001; 52: (1) Page 9.
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Published
2018-02-07
How to Cite
Hartalkar, D. A., & Hartalkar, D. S. (2018). Study of Coulter Indices After Oral & Parenteral Iron Therapy In Iron Deficiency Anaemia: Study of Coulter Indices After Oral & Parenteral Iron Therapy In Iron Deficiency Anaemia. National Journal of Integrated Research in Medicine, 7(2), 113–118. https://doi.org/10.70284/njirm.v7i2.1370
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