Levosulpiride and Esomeprazole Induced Hyperprolactinemia Case Report of Drug Induced Hyperprolactinemia

Levosulpiride and Esomeprazole Induced Hyperprolactinemia: Drug Induced Hyperprolactinemia

Authors

  • H Rajgadhi
  • H Makwana
  • S Malhotra
  • P Patel

Keywords:

Galactorrhea, Hyperprolactinemia, Levosulpiride(LEVO), Esomeprazole(OMZ)

Abstract

Hyperprolactinemia is a condition of raised serum prolactin levels which can be drug induced also manifesting as galactorrhea, menstrual problems and infertility in women. Levosulpiride is used in the treatment of psychoses, anxiety disorders and now a days also used in treatment of GERD. The action of Levosulpiride is attributed to 5-HT4 receptors agonism in the enteric system. This is the case report of 22-year-old lady who presented with galactorrhea due to intake of two drugs Levosulpiride and Esomeprazole prescribed for the treatment of Gastroesophageal Reflux Disease.[H Rajgadhi NJIRM 2017; 8(3):158-160]

References

1. Deulgaonkar YB, Patel JA, Mahajan MP, Sawant SD. A simple and validated rp-hplc method for the simultaneous estimation of levosulpiride and rabeprazole sodium in bulk and pharmaceutical dosage forms. Iajpr. (2013), [cited february 25, 2016]; 3(5): 4017-4025
2. Robert CL.Medical management of gastroesophageal reflux disease PART 1 Oral cavity, pharynx and esophagus, GI Motility online ,16 May 2006
3. Haddad PM, Wieck A. Antipsychotic-induced hyperprolactinaemia:mechanisms, clinical features and management. 2004; 4:2291–314
4. Rao R,BhatR,Patil N. A rare instance of Levosulpiride–induced galactorrhea, international journal of pharmacy and pharmaceutical science,2016; Vol 8, Issue 4, 398-399.
5. Nirav P, Dattatray S,et al. Esomeprazole induced galactorrhea: a novel side effect, Clinical Journal of Gastroenterology, 2016:9:13-16
6. Chimorgiachis, A., and D. Marinescu. "Causes and management of antipsychotic-induced hyperprolactinemia." Romanian journal of psychopharmacology 7.1: 51.
7. Kang CD, Song CW,et al. Effects of Levosulpiride in Patients with Nonspecific Esophageal Motility Disorder. Korean Journal of Gastrointestinal Motility 1999; 5: 111-118

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Published

2018-02-04

How to Cite

Rajgadhi, H., Makwana, H., Malhotra, S., & Patel, P. (2018). Levosulpiride and Esomeprazole Induced Hyperprolactinemia Case Report of Drug Induced Hyperprolactinemia: Levosulpiride and Esomeprazole Induced Hyperprolactinemia: Drug Induced Hyperprolactinemia. National Journal of Integrated Research in Medicine, 8(3), 158–160. Retrieved from http://nicpd.ac.in/ojs-/index.php/njirm/article/view/1268

Issue

Section

Case Report