An Unusual Case of Pyrazinamide Induced Erythema Multiforme in A Patient of Tuberculous Meningitis: A Case Report
An Unusual Case of Pyrazinamide Induced Erythema Multiforme in A Patient of Tuberculous Meningitis
Keywords:
Erythema Multiforme, AKT, Pyrazinamide, RechallengeAbstract
Erythema Multiforme (EM) is a skin condition having various aetiologies including drugs. Pyrazinamide, one of the 1st line Antitubercular drugs (AKT) is known to cause various adverse effects. However, reports of Pyrazinamide induced EM are rare. In the below mentioned case, the patient had presented to Dermatology Department with skin lesions after taking AKT for two months prescribed for Tuberculous Meningitis. These AKT drugs were withdrawn and reintroduced one by one. Rechallenge was performed with Pyrazinamide. The lesions had reappeared with reintroduction of Pyrazinamide. Thus the diagnosis of Pyrazinamide induced EM was confirmed. This adverse drug reaction (ADR) is also reported to the WHO-Uppsala Monitoring Centre via Vigiflow Base. Key Message: Skin hypersensitivity reactions to Pyrazinamide can be rare but serious. They usually begin after 4-6 weeks of treatment. They need to be recognized early and the physician shout be watchful once the patient commences AKT. [Haiya S NJIRM 2017; 8(3):153-155]
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