A Study on Susceptibility Pattern of Nitrofurantoin in Clinical Isolates of Enterococcus
A Study on Susceptibility Pattern of Nitrofurantoin in Clinical Isolates of Enterococcus
Keywords:
Enterococci, Antibiotic susceptibility testing, NitrofurantoinAbstract
Introduction: Recent years have witnessed a resurgence of interest in enterococci due to increasing resistance to antibiotics in term of both multiplicity of resistance & level of resistance to particular drugs. In such scenario nitrofurantoin may be the effective option specially in case of urinary tract infection cause by enterococcus. Methodology: This is a hospital based study, conducted in Microbiology Department of an medical college in M.P. Antibiotic susceptibility performed on enterococci isolated from urine samples in the study period of one and half year Result: Enterococcal species isolated mainly E.faecalis (86.62%) and E.faecium (15.18%). In Enterococcus, 89.4% isolates showed resistance to Penicillin, 58.8% to Ampicillin, 61.1% to High Level Gentamicin (HLG) and 54.1% to High Level Streptomycin (HLS) Nitrofurantoin (24.7%), Ciprofloxacin (61.2%), Levofloxacin (63.5%), Norfloxacin (64.7%), Tetracycline (54.1%). Discussion: Our study showed that only 40% E.faecalis and 10% of E.faecium were resistant to nitrofurantoin. Similar result published from Nagpur by Rahangdale et al. According to them enterococci showed only 22.76 % resistant to nitrofurantoin. Conclusion: Enterococcus show very good susceptibility for nitrofurantoin as compare to other commonly use antibiotic for treatment of enterococcal infection. [Saurabh J NJIRM 2017; 8(3):53-56]
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