Emergence of Tigecycline Resistance in Multidrug Resistant (MDR) Organisms Isolated At Tertiary Care Hospital, Ahmedabad
Emergence of Tigecycline Resistance in Multidrug Resistant (MDR) Organisms Isolated
Keywords:
Tigecycline, MDR, E-test, MIC, Acinetobacter, MRSA, VRE, EnterobacteriaceaeAbstract
Objective & Background: Tigecycline is the first glycylcycline antibiotic to be approved by US Food and Drug Administration (FDA) and therapeutic agent for serious infections caused by multidrug resistant organism. This study is to evaluate the emergence of Tigecycline resistance in MDR organisms. Method: This study was conducted over a period of July 2016 to 15th Nov 2016. A total of 217 Multi Drug Resistant Organisms (MDRO) isolated from various clinical specimens except urine, as per standard protocols and antibiotic sensitivity. Out of which 36 Methicillin Resistant Staphylococcus ( MRSA) , 3 Vancomycin Resistant Enterococci (VRE) ,91 Multidrug resistant Acinetobacter spp and 87 MDR Enterobacteriaceae, are tested for Tigecycline (TIG) resistance by disc diffusion Method and Minimum inhibitory concentration (MIC) was determined by E-test gradient strip. Result: All the isolates for MRSA, VRE shows 0% resistant to Tigecycline but 6 (6.89%) of MDR Enterobactiaceae and 15 (16.48 %) of MDR Acinetobacter spp. were found to be resistant to Tigecycline. Conclusion: Tigecycline was found to be highly effective against gram positive bacteria and resistance is observed in Acinetobacter spp. and Enterobacteriaceae, especially in multidrug-resistant strains. So before starting the treatment, susceptibility to Tigecycline should be assessed, to prevent the development and the dissemination of resistance against this one of the last available promising and safe therapeutic options which is available to the clinicians for combating these bacteria. [Mamta K NJIRM 2017; 8(2):153-157]
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