Prevalence And Antimicrobial Susceptibility Pattern Of Methicillin Resistant Staphylococcus Aureus From Health Care.(AMR)
Prevalence And Antimicrobial Susceptibility Pattern Of MRSA
Keywords:
MRSA, Antimicrobial susceptibility, resistanceAbstract
Introduction: Methicillin resistant Staphylococcus aureus (MRSA) causes clinically challenging infections with attributable morbidity and mortality. Both the prevalence of MRSA infections and appearance of drug resistance have been increasing steadily leaving few antibiotic options remain available for treatment. Objective: To study antimicrobial susceptibility pattern of MRSA isolated from clinical specimens so that effective therapeutic options can be find out. Material Methods: The study was conducted from April 2016 to November 2016. The clinical specimens received in the laboratory were processed as per standard microbiological techniques. The isolated organisms were identified by biochemical test. All the isolated organisms were subjected to antimicrobial susceptibility testing by modified Kirby baur disc diffusion method and results were interpreted as per CLSI guidelines. The isolated Staphylococcus aureus were screened for MRSA by Cefoxitin for presence of MecA mediated Oxacillin resistance. If screening test was positive, it was subjected to Oxacillin MIC and results were interpreted as per CLSI guidelines. Result: A total 12.75% MRSA were isolated out of all S.aureus. The susceptibility profile shows – Linezolid, Teicoplanin, Vancomycin 100% of susceptibility. Chloramphenicol, Moxifloxacin show 20% of resistance. Amikacin, Doxycycline, Sparfloxacin, Tetracycline show 40% of resistance. Ciprofloxacin, Levofloxacin, Co- trimoxazole, Gentamycin drugs show 40 to 60% of resistance. Conclusion: Though Linezolid, Teicoplanin, Vancomycin drugs showing sensitivity and giving potential therapeutic option but should be limited as reserve drug to inhibit the spread of resistance. Hence there is a need of awareness among clinicians about the judicious use of antibiotics. Strict infection control practice to inhibit spread of resistance in hospital settings. [Chirag K NJIRM 2017; 8(2):146-148]
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