iPTH and Heart Failure: An Association
iPTH and Heart Failure: An Association
Keywords:
Heart Failure, iPTH, Cardiovascular diseaseAbstract
Background: Heart failure is a major public health burden. It is associated with considerable morbidity and mortality. There is a complex relationship between genetic, neuro hormonal, inflammatory and biochemical changes in the heart. High PTH level has been found to be associated with increased heart failure hospitalization. PTH has been shown to be an independent predictor of all cause and cardiovascular mortality in patients with heart failure. Strong correlation between high PTH level and advanced heart failure has been observed We tried to find out an association between iPTH and Heart Failure. Method: A pilot case control study involving 50 subjects (25 cases and 25 controls) have been done to identify the level of iPTH, 25 hydroxy vitamin D, serum phosphate and ionized calcium in heart failure patients. Serum iPTH and 25 hydroxy Vitamin D estimation was performed on Abbott Architect i1000 SR Analyzer using enhanced chemiluminescent immunoassay technique. Serum creatinine, phosphate and alkaline phosphatase were analyzed on fully automated analyzer AU480 from Beckmann Coulter using spectrophotometric technique. Statistical Analysis has been done by SPSS. Results: The level of iPTH, phosphorous and calcium significantly varied among both the groups (case and control); p value is less than 0.05. Interpretation and Conclusion: In our study it has been found that iPTH level is high in heart failure cases compared to controls which are statistically highly significant. Therefore the study indicates a strong association of iPTH and heart failure. [Anupa P NJIRM 2017; 8(2):123-125]
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