Antibiotic Susceptibility Pattern of Uropathogens in Pediatrics Patients
Antibiotic Suceptibility Pattern Of Uropathogens In Paediatrics Patients
Keywords:
Children, urinary tract infection, uropathogensAbstract
Background & Objectives: To identify the pathogens and their antibiotic susceptibility patterns in UTI cases in Paediatric patients.To help in implementation of better therapeutic strategies to reduce morbidity and mortality in Paediatric patients. Methods: Urinary isolates were analyzed retrospectively, data was collected and analysed. Isolation and identification of pathogens was done by standard microbiological method and antibiotic susceptibility test was done using modified Kirby-Bauer disk diffusion method according to current Clinical and Laboratory Standard Institute (CLSI) guidelines. Results: Out of total 1001 urine samples uropathogens were isolated from 334(33.4%) samples. The pathogensisolated were:219/334(65.6%) Enterobacteriacae, 52/334(15.6%) Nonfermenters, 41/334(12.3%) Candida spp, 22/334 (6.5%) GPC (Gram positive cocci).In the Enterobacteriacae group most common pathogen isolated wasE. colifollowed byKlebseilla spp. Most of these isolates were resistant to commonly used antibiotics like 2nd and 3rd generation cephalosporins, fluoroquinolones and were sensitive to carbapenams, nitrofurantoin and newer fluoroquinolones like levofloxacin. Among the nonfermenters,Pseudomonas were resistant to 3rd generation cephalosporins and sensitive to imipenam and polymyxin B. Conclusion: In the spectrum of paediatric UTI, Enterobacteriacaeare the most common etiology and they exhibit high degree of drug resistance to commonly used antibiotics. Suitable antibiotic policy can help in minimising drug resistance. [Padaria N NJIRM 2017; 8(2):51-54]
References
2. Pal N, Rit K, Naskar S, Kumar S, Guhathakurata R. A study of bacteriological and antibiotic susceptibilityprofile of pediatric urinary tract infection with special emphasis onextended spectrum beta-lactamase production in a tertiary care hospitalof Eastern India. Int J Health Allied Sci 2016;5:257-62.
3. Sharma A, Mishra B, Dogra V. Microbiologicspectrum and susceptibility pattern of urinary isolates from pediatricpatients in a superspecialty Hospital: A 3-year experience. Indianj health sci 2016;9:137-41.
4. Narasimhan KL, Chowdhary SK, Kaur B, Mittal BR, Bhattacharya A.Factors affecting renal scarring in posterior urethral valves. J PediatrUrol 2006;2:569‑74.
5. Mohammad Al-Shara, Saudi J Kidney Dis Transpl 2011;22(6):1249-1252.
6. Taneja N, Chatterjee SS, Singh M, Singh S, Sharma M. Pediatricurinary tract infections in a tertiary care center from North India.Indian J Med Res 2010;131:101‑5.2011 Saudi Center for Organ Transplantation
7. Ghorashi Z, Ghorashi S, Soltani‑Ahari H, Nezami N. Demographicfeatures and antibiotic resistance among children hospitalizedfor urinary tract infection in Northwest Iran. Infect Drug Resist2011;4:171‑6.
8. Muratani T, Matsumoto T. Bacterial resistance to antimicrobials inurinary isolates. Int J Antimicrob Agents 2004;24Suppl 1:S28‑31.
