Use of Beyond-Linearity Quality Control Sera for Routine Internal Quality Control of Glucose and Creatinine

Abstract

Introduction: While linearity of assay is tested during validation, there is no day to day check on changes thereof, although change in linearity will affect results around the linearity limits. Objectives: The study was performed to see if introduction of such beyond linearity QC program is useful to the laboratory or not. Methods: Serum control pool of beyond linearity range was prepared and analysed along with the routine quality controls and the incidences of rejections of routine internal controls and beyond linearity controls were compared. Results: There was general correlation in rejection incidences between routine QC and Beyond-linearity QC for both 1(3S) and 2(2S) QC rules. Interpretation and conclusion: The study shows that, there is no major increase in error detection rate on introduction of beyond-linearity QC. However, there was increase in warnings 1(2S) signs with beyond linearity QC. [Nilam K NJIRM 2017; 8(1): 77-81]