Use Of Mifepristone To Reduce The Induction Abortion Time In Patients With First and Second Trimester Terminations: An Observational Study
Use Of Mifepristone To Reduce The Induction Abortion Time
Keywords:
mifepristone, misoprostol, induction-expulsion timeAbstract
In the developing countries unsafe abortions form a major factor for increased maternal morbidity and mortality. The use of medications like prostaglandin derivatives one of them beingmisoprostol can help in reducing these catastrophic events. The addition of mifepristone prior to misoprostol has been seen to be effective for reduction in induction abortion time. We conducted a studyto investigate the effect of mifepristone before administration of the prostaglandin derivative on induction abortion time. Method:This study was conducted in 1016 patients from April 2012 till March 2016. The patients were randomised into two groups with combination or study group “A†comprising of 512 patients and control group using misoprostol alone having 504 patients. Results: The age of the patients ranged from 21 to 46 years. Majority of the patients were in age group 21 to 30 (n=660, 64.9%). Most of the patients were primigravida (n= 459, 45.17%). The combination grouphad a shorter interval time between the induction and expulsion of the products to the tune of 14.95± 10.95 hours. On the other hand the patients in misoprostol only group (n=504) had an induction expulsion time of 24.4±20.6 hours. This difference in the expulsion time was statistically significant with p value of <.001. There was no mortality or major morbidity in the two groups.Conclusions: We were able to document that mifepristone followed by misoprostol 24 hours later led to the most rapid abortions as compared to use of a single drug. The safety profile of the drug combination was same as the single drug. We strongly recommend combination of mifepristone and misoprostol to reduce the abortion time which can help quicker discharge of the patient from the hospital and reduce the congestion in our wards. [Anjum M NJIRM 2017; 8(1): 17-20]
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