Prevalence and outcome of Hepatitis B infection in antenatal Mothers
Prevalence And Outcome Of Hepatitis B Infection In Antenatal Mothers
Keywords:
Hepatitis B virus , Prevalence , HBsAg ,HBeAg , Vertical TransmissionAbstract
Objective: To study the prevalence and pregnancy outcome of Hepatitis B infection in antenatal Mothers Methods: In this prospective randomized study a total of 500 women were included with viable pregnancy before 38 weeks of gestation . After a thorough history and complete examination , 2 ml of venous blood was collected in a test tube after informed consent. Evaluation of maternal serum Hepatitis B surface antigen (HBsAg) and Hepatitis B envelope antigen (HBeAg) were done by chromatographic immunoassay Method. Similarly cord blood of neonates at delivery was taken for evaluation of Hepatitis B surface antigen by chromatographic immunoassay. Results: 12 (2.4%) out of the 500 women studied were found to be positive for Hepatitis B surface antigen (HBsAg). None of them were found positive for serum HBeAg, thus implying that they were not in the infective stage for vertical transmission, this is highly significant. Assessment of risk factors revealed history of blood transfusion, surgery and parenteral exposure were 3 cases each. Only one case was having history of jaundice. All the 12 (2.4%) neonates born to HBsAg positive mothers , were negative for HBsAg. Hence the risk of vertical transmission of Hepatitis B virus (HBV) infection was low if mother is HBeAg negative. Conclusion: seroprevalence of HBsAg in antenatal women was found to be 2.4% .As vertical transmission is responsible for majority of infections, it is desirable to screen all the pregnant women for HBsAg and immunize the neonates. [Sonika D NJIRM 2017; 8(1): 13-16]
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